Orladeyo Alternatives Compared
| Orladeyo (berotralstat) | Haegarda (C1 esterase inhibitor (human)) | Andembry (garadacimab) |
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| Orladeyo (berotralstat) | Haegarda (C1 esterase inhibitor (human)) | Andembry (garadacimab) |
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Prescription only
Orladeyo is an oral, once-daily medication used to prevent angioedema attacks in adults and children 12 years and older with HAE. It is the only oral preventive treatment for HAE attacks currently... View more |
Prescription only
Haegarda works by replacing missing C1 protein in the blood of adults and children over the age of 6 with hereditary angioedema (HAE) preventing the generation of bradykinin and angioedema attacks... View more |
Prescription only
Prescribed for Hereditary Angioedema. Andembry may also be used for purposes not listed in this medication guide. |
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| More about Orladeyo (berotralstat) | More about Haegarda (C1 esterase inhibitor (human)) | More about Andembry (garadacimab) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Orladeyo has an average rating of 6.7 out of 10 from a total of 3 ratings on Drugs.com. 33% of reviewers reported a positive effect, while 0% reported a negative effect. |
Haegarda has an average rating of 8.0 out of 10 from a total of 2 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. |
Be the first to share your experience with this drug. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
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View all Orladeyo side effects |
View all Haegarda side effects |
View all Andembry side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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N/A |
N/A |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Orladeyo prices |
View all Haegarda prices |
View all Andembry prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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N/A |
Other C1 esterase inhibitor (human) brands include: Berinert, Cinryze |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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152 hours |
152 hours |
417.6 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 524 drugs are known to interact with Orladeyo:
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A total of 51 drugs are known to interact with Haegarda:
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A total of 3 drugs are known to interact with Andembry:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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December 03, 2020 |
N/A |
June 16, 2025 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Professional Resources | ||||||||||||||||||||||||||
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N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.