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Orladeyo Dosage

Generic name: Berotralstat hydrochloride 150mg
Dosage form: capsule

Medically reviewed by Drugs.com. Last updated on Dec 3, 2020.

Recommended Dosage

The recommended dosage of ORLADEYO is one 150 mg capsule taken orally once daily with food.

Recommended Dosage in Patients with Hepatic Impairment

No dosage adjustment of ORLADEYO is recommended for patients with mild hepatic impairment (Child-Pugh Class A) [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)].

In patients with moderate or severe hepatic impairment (Child-Pugh B or C), the recommended dosage of ORLADEYO is one 110 mg capsule taken orally once daily with food [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)].

Recommended Dosage for Concomitant Use with P-gp or BCRP Inhibitors

In patients with chronic administration of P-gp or BCRP inhibitors (e.g., cyclosporine), the recommended dosage of ORLADEYO is one 110 mg capsule taken orally once daily with food [see Drug Interactions (7.1) and Clinical Pharmacology (12.3)].

Dosage Adjustment in Patients with Persistent GI Reactions

Gastrointestinal (GI) reactions may occur in patients receiving ORLADEYO [see Adverse Reactions (6.1)]. If GI events persist, a reduced dose of 110 mg once daily with food may be considered.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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