Medically reviewed by Drugs.com. Last updated on Apr 18, 2022.
Generic name: Berotralstat hydrochloride 150mg
Dosage form: capsule
The recommended dosage of ORLADEYO is one 150 mg capsule taken orally once daily with food.
Recommended Dosage in Patients with Hepatic Impairment
In patients with moderate or severe hepatic impairment (Child-Pugh B or C), the recommended dosage of ORLADEYO is one 110 mg capsule taken orally once daily with food [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)].
Recommended Dosage for Concomitant Use with P-gp or BCRP Inhibitors
In patients with chronic administration of P-gp or BCRP inhibitors (e.g., cyclosporine), the recommended dosage of ORLADEYO is one 110 mg capsule taken orally once daily with food [see Drug Interactions (7.1) and Clinical Pharmacology (12.3)].
Dosage Adjustment in Patients with Persistent GI Reactions
Gastrointestinal (GI) reactions may occur in patients receiving ORLADEYO [see Adverse Reactions (6.1)]. If GI events persist, a reduced dose of 110 mg once daily with food may be considered.
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