Garadacimab
Generic name: garadacimab
Brand name: Andembry Prefilled Autoinjector
Dosage form: subcutaneous solution (gxii 200 mg/1.2 mL)
Drug class: Hereditary angioedema agents
What is garadacimab?
Garadacimab is used to prevent attacks of hereditary angioedema (HAE) in adults and children at least 12 years old.
Garadacimab may also be used for purposes not listed in this medication guide.
Garadacimab side effects
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Common side effects of garadacimab may include:
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pain, bruising, swelling, or irritation where the medicine was injected;
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watery eyes;
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stomach pain; or
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sneezing, runny or stuffy nose.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Related/similar drugs
Warnings
Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.
Before taking this medicine
You should not use garadacimab if you are allergic to it.
It is not known if garadacimab will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Ask a doctor if it is safe to breastfeed while using garadacimab.
How should I use garadacimab?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Garadacimab is injected under the skin. A healthcare provider may give you this injection or may teach you how to properly use this medicine by yourself.
Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors or has particles in it.
Take the medicine out of the refrigerator and let it reach room temperature for 30 minutes before using.
Do not inject within 1 inches of your navel (belly button), or areas where the skin is hard, tender, bruised, or has scars. Do not inject into the same place two times in a row.
Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.
Store the medicine in the original carton in a refrigerator away from light. Do not shake the medication. Do not freeze.
Garadacimab dosing information
Usual Adult Dose for Hereditary Angioedema:
Initial loading dose: 400 mg subcutaneously on day 1
Maintenance dose: 200 mg subcutaneously once a month
Use: For prophylaxis to prevent attacks of hereditary angioedema (HAE)
Usual Pediatric Dose for Hereditary Angioedema:
12 years and older:
Initial loading dose: 400 mg subcutaneously on day 1
Maintenance dose: 200 mg subcutaneously once a month
Use: For prophylaxis to prevent attacks of HAE
What happens if I miss a dose?
Use the missed dose as soon as you remember it. Do not use two doses in one day.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using garadacimab?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Do not share garadacimab with another person, even if they have the same symptoms you have.
What other drugs will affect garadacimab?
Other drugs may affect garadacimab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
Garadacimab Biosimilars
Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.
Reference products
These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for garadacimab.
Andembry (garadacimab-gxii) - CSL Behring LLC
| Formulation type | Strength |
|---|---|
| Autoinjector | 200 mg/1.2 mL (167 mg/mL) |
| Pre-Filled Syringe | 200 mg/1.2 mL (167 mg/mL) |
View Andembry information in detail.
More about garadacimab
- Check interactions
- Compare alternatives
- Dosage information
- During pregnancy
- Drug class: hereditary angioedema agents
- En español
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Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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