Comparing Flonase vs Benadryl
Flonase | Benadryl |
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Flonase (fluticasone) | Benadryl (diphenhydramine) |
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Over-the-counter
Flonase reduces inflammation and nasal symptoms associated with rhinitis; however, Flonase may cause nose bleeds and it takes about three days for the full effects to be seen. Prescribed for... View more |
Prescription and OTC
Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect... View more |
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More about Flonase (fluticasone) | More about Benadryl (diphenhydramine) | ||||||||
Ratings & Reviews | |||||||||
Flonase has an average rating of 4.9 out of 10 from a total of 183 ratings on Drugs.com. 38% of reviewers reported a positive effect, while 51% reported a negative effect. |
Benadryl has an average rating of 7.2 out of 10 from a total of 76 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 19% reported a negative effect. |
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Drug Class | |||||||||
Side Effects | |||||||||
See also: Flonase side effects in more detail. |
See also: Benadryl side effects in more detail. |
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Generic Availability | |||||||||
N/A |
N/A |
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Pricing and Coupons * Prices are without insurance | |||||||||
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Benadryl prices |
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Dosage Forms Available | |||||||||
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Brand Names | |||||||||
Other fluticasone brands include: Flonase Allergy Relief, Flonase Sensimist, Ticanase, Xhance | Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | ||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||
8 hours |
9.3 hours |
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CSA Schedule ** View glossary of terms | |||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||
A total of 50 drugs are known to interact with Flonase:
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A total of 448 drugs are known to interact with Benadryl:
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Alcohol/Food/Lifestyle Interactions | |||||||||
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | |||||||||
First Approval Date | |||||||||
N/A |
March 04, 1946 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||
N/A |
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More Information | |||||||||
Patient resources | |||||||||
Professional Resources | |||||||||
Related Treatment Guide | |||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.