Zanubrutinib for Chronic Lymphocytic Leukemia User Reviews

• Coz...
• Taken for 1 to 6 months
• December 12, 2023

Zanubrutinib "I was diagnosed with CLL a little over 3.5 years ago at age 70. We were on a 'wait and see' routine up until about 6 weeks ago. My oncologist said I should go on treatment and he recommended Brukinsa. Being a little 'freaked' out about having to go on treatment, I contacted MD Anderson. My wife and I flew to Houston and had an array of blood tests done. 19 vials. The Dr. was very kind and patient and explained CLL and the clinical trials they are now conducting. I asked him what he would do in my situation, he said to stay the course on Brukinsa as it is one of the newest of the BTK inhibitors. So, for right now, I'm sticking to Brukinsa. As far as side effects, I haven't noticed any."

• Mar...
• Taken for 1 to 6 months
• April 26, 2024

Zanubrutinib "Taking it since November 2023 for SLL. Within a week, all bulky adenopathy melted away with transient high lymphocyte blood levels, but normal range in a few months. I have mild fatigue and low immune function, but have not been ill otherwise. Constipation managed with Metamucil and diet changes. I noticed slightly increased bleeding during oral care and just noticed petechiae on my legs today, very minor. Labs have been good, but decreasing neutrophils, basophils, eosinophils. 160 mg bid"

• Vic...
• Taken for 1 to 6 months
• September 26, 2024

Zanubrutinib "My mom, 74 years old, started taking Brukinsa recently on Aug 20, 2024. All swelling lymph nodes on the collarbone and underarms are gone. She is losing a little weight, no side effects. I have noticed some skin dryness and wrinkles around the neck, a little fatigue, but overall, much better than before treatment. Thanks to the lymphoma clinic in Fred Hutch Cancer Center, Seattle, and thanks to the Beigene company and their support team."

• JGT...
• Taken for less than 1 month
• July 9, 2024

Zanubrutinib "I just started Brukinsa 3 weeks ago. I take 320 mg in one dose in the morning. It has not caused any discomforting symptoms. I had lab work done today, and my lymphocyte count went from 171 x 1000 down to 65 x 1000. My platelets are well within the normal range, but my hemoglobin went from 10 down to 9.5."

• Anonymous
• Taken for 1 to 2 years
• February 3, 2024

Zanubrutinib "Side effects come and go but are common, lasting a few hours or a couple of days, like joint and muscle pain, especially to areas that were previously injured. Otherwise, no problem handling them. Remission occurred in six months."

• DRT...
• Taken for 1 to 2 years
• March 29, 2024

Zanubrutinib "Continuing to work extremely well after one year. Some fatigue, and presently having persistent nasal congestion and sneezing, but not sure if it is from the medication. All of my blood counts returned to normal after one month, and have remained normal."

• Ste...
• Taken for 1 to 6 months
• August 7, 2024

"I started Brukinsa about two months ago after tests revealed that the CLL had invaded my bladder and prostate. My oncologist first started me on Obinutuzumab + Venetoclax, but I had a severe reaction, and she changed my protocol to Brukinsa. To date, I have had no discernible side effects, and I have noticed that my lymph nodes are shrinking. I feel generally good, and my energy level remains high."

• MJB...
• Taken for 1 to 2 years
• November 17, 2024

"White blood cell count reduced dramatically to just under 10, after a brief spike to 200. Only side effect is random small bruises. Maintaining normal lifestyle with good energy. I am very grateful and have a new appreciation for life:)"

• Luc...
• Taken for 1 to 6 months
• November 16, 2024

Zanubrutinib "Although at last report, white blood cell count went down a little. Having many symptoms worse if cough, runny nose, very nervous, dry mouth, many skin problems arms at times almost black.... tiredness (usually very active), weight gain, swelling of limbs, breasts, etc., top of leg numbness."

• Nic...
• Taken for 1 to 6 months
• June 12, 2024

"Diagnosed in 2013 and had treatment in 2019 with bendamustine-rituximab. I was in remission for nearly 3 and a half years when my CLL returned. I have now completed my first month of zanubrutinib. No side effects so far and noticed that the fatigue I was feeling has significantly lessened."

• Ano...
• Taken for 1 to 6 months
• May 10, 2025

Zanubrutinib "Large red bruise-like patch covering left arm almost completely with small blood bubbles under the skin. Medication 2 months. Lymphs are shrinking rapidly. Based on CT and the shrinking of lymph, I rate it a 10, but I wish the bruises would diminish. No other reactions. Platelets seem WNL. All other labs except WBC 450 and lymphocytes okay, and I don’t have factors."

• a k...
• Taken for 6 months to 1 year
• April 9, 2025

Zanubrutinib "I've experienced 24 different side effects since starting my treatment last year. Other than an extremely high white blood count, few, if any, of these side effects existed, and I really did not feel bad before the treatment."

• dmp...
• Taken for less than 1 month
• February 1, 2024

Zanubrutinib "I started on Brukinsa on the 5th. I marked improvement in my headaches. I was on Imbruvica since March of 21, starting at 420mg and then reduced to 280mg in hopes of reducing headaches. There was no improvement, so I was taken off it totally on November 15th. I still have issues with bad headaches, but the intensity isn't as bad."

• Jan...
• Taken for 1 to 6 months
• December 19, 2024

"Headaches, lower back pain, and I look very pale. I take 80 mg, 1 capsule daily. I have only been on this medicine for a bit over a month, so maybe it is too soon to tell what exactly is happening. I will see my doctor in January 2025 and discuss any problems or lack of at that time. This is a very easy medicine to take, and I hope it turns out to work well for me."

• mea...
• Taken for 6 months to 1 year
• June 1, 2025

Zanubrutinib "It brought my white blood cell count down from 180k to a normal level of 7k. It also normalized my red blood count and hemoglobin from dangerously low levels. After my diagnosis of CLL, I was on a watch and wait protocol. About a year into it, my energy level dropped and weight loss was at serious levels. My oncology doctor put me on Brukinsa and after 3 months my blood count was normalized. I gained most of the weight back and returned to most of my daily activities within 6 months. My dosage level was a convenient 2 times daily, 2-80mg capsules (320 mg total daily). AON Pharmacy has been the best, over-the-top group of people to work with ever. I love them! I am now nearly a year into the Brukinsa treatment. I am having difficulty with muscle tone and normal strength levels, dizziness, close experiences with fainting, and leg muscle fade to weakness. I attribute these as side effects and am now worried about heart issues."

• Ano...
• Taken for 1 to 6 months
• May 27, 2025

Zanubrutinib "This medication is extremely hard on my GI tract, causing pain 15 minutes after I take the medication. I can feel it as it moves through my GI tract due to where the pain is in my abdomen. I am also experiencing extreme fatigue and joint pain. It has decreased the size of my lymph nodes and my LDH and blood counts are improving. But, there is a cost-both physically and financially."

• Tho...
• Taken for 1 to 2 years
• June 30, 2025

Zanubrutinib "A few months after starting Brukinsa, I began to break out in rashes and sores on my arms and scalp. My skin started itching, especially on my head. Hydrocortisone cream and medicated shampoo and medicated skin cream took care of all that. I also take a buttload of supplements - Vitamin C, Vitamin E, multivitamins, selenium, Vitamin D3, etc. - along with four doses of iron every day to keep my red blood cell levels up. It will be two years in November since I started on it, and so far it works like a charm. Unfortunately, it also increases my joint pain. But I exercise regularly and eat right most of the time. Lots of walking, playing drums and going to the gym, so that, as well as a dose of Tramadol 2-3 times a week, keeps my pain at bay. I don't take any other prescription drugs. I'm 63 years old and still have some living to do, so thank God for Brukinsa!"

• Ano...
• Taken for 1 to 2 years
• May 8, 2025

Zanubrutinib "I've been taking Brukinsa for a year. I take two pills twice a day. The pills are easy to swallow. The only side effect I've experienced is bruising. Occasionally, I have a slight headache, but not bad enough that I need to take anything. My blood counts were in range within 2 months of starting Brukinsa."

• Bru...
• Taken for 1 to 6 months
• February 3, 2024

Zanubrutinib "Already 4 months on Brukinsa. All enlarged lymph nodes have disappeared. Very minor side effect - upper right foot skin sensitivity. So far, it has worked very well for me."

• Ste...
• Taken for less than 1 month
• March 3, 2024

Zanubrutinib "4 weeks so far so good. No side effects. Lymphs have gone down."

• Sim...
• Taken for 1 to 6 months
• May 20, 2024

Zanubrutinib "Rash on face after 1st month; I started to cough out blood after 8 weeks"

• Ano...
• Taken for 1 to 6 months
• April 16, 2025

Zanubrutinib "Dosage: 160 mg b.i.d. Significantly improved labs. Side effects have been manageable and include nausea, bruising, cough, musculoskeletal pain, constipation, and headaches."

• Ton...
• Taken for 1 to 6 months
• March 19, 2025

Zanubrutinib "I've been on this treatment plan since December 28, 2024, and so far, well tolerated. Haven't had any side effects from it and was diagnosed with CLL!"

• joh...
• Taken for less than 1 month
• March 15, 2025

Zanubrutinib "Been 3 weeks now. So far, pretty good, just a bit of nausea. Goes away after an hour or two."

• Anonymous
• Taken for less than 1 month
• June 3, 2024

Zanubrutinib "At times, after taking Brukinsa, seem to feel tired."