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Interferon beta-1a and Tiredness: What Users Say

Brand names: Avonex, Rebif, Rebif Rebidose, Avonex Pen, Avonex Prefilled Syringe

Tiredness: mentioned by 6 users (6.1%)

Based on user experiences from 98 Interferon beta-1a reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

flu-like symptoms 31.6%
headaches 14.3%
chills 10.2%
fatigue 9.2%
body aches 6.1%
fever 6.1%
tiredness 6.1%
injection site pain 5.1%
pain 5.1%
numbness 4.1%

Reviews for Interferon beta-1a

Commonly mentioned side effects
  • Nur...
  • Taken for 5 to 10 years
  • March 29, 2014

For Multiple Sclerosis "I have been on Avonex for about 5 years and have had no relapses. Have had Multiple Sclerosis for 14 years. Great to have 1 injection a week rather than 3 with Rebif, which I was on before or Copaxone every day. The only drawback is the headache and tiredness felt the day after. These symptoms have not improved at all for 5 years. Starting to have spasm attacks at night recently, so might change to another medicine. Very effective medicine, though, never had any relapses, and that's the most important thing!"

9 / 10
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31 Report
  • ASY...
  • Taken for 5 to 10 years
  • April 3, 2013

For Multiple Sclerosis "Diagnosed in 1999 and was placed on Rebif since 2004. Never had any other meds. Overall, Rebif was good for me. I had 3 years with a minor relapse in each year (but did steroid treatment to resolve), and then I had no relapses. I must admit that I would skip at least 2 times a year and give myself a Rebif holiday-a week of not taking Rebif (I don't recommend this!). I would always let my doctor know. Despite my success, I stopped in 10/2012 because Rebif never let me feel like myself and I was ALWAYS tired and sluggish. Unfortunately, in 3/2013 I had a terrible relapse that landed me in the hospital for a few days. My neuro said it was aggressive and wants me on Tysabri now."

9 / 10
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23 Report
  • chi...
  • March 25, 2010

For Multiple Sclerosis "I have had MS for over 25 years now and have been on Avonex for about 2 months. I find the shots to be tolerable (given to me by someone else), and the side effects are not too horrible. About 6 hours after injection, I have chills, muscle and joint aches, and a slight headache. These effects last for approx. 4 hours. The following day, I feel tired but okay. Not sure if it is helping. I hope so... time will tell. After all is said and done, the shots and the side effects are not so bad."

5 / 10
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13 Report
  • msg...
  • November 15, 2008

For Multiple Sclerosis "I have used Avonex for about a month now to treat my MS. I have a mild case, and symptoms are not too severe. I appreciate the once-a-week injection (hate needles) but am feeling the side effects. I use Tylenol PM when I take the injections, and that does seem to help. We take the injections on Thursday, and I am able to work from home on Fridays. I am very tired, but usually better by Saturday. I definitely recommend this based on the once-a-week injection vs. the daily or every-other-day injection of the other choices for MS. Good luck."

9 / 10
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15 Report
  • Car...
  • Taken for 5 to 10 years
  • September 11, 2021

For Multiple Sclerosis "Not a lover of injections, but once a week I will persevere. It’s been about five years since I had a flare-up. It’s just the psychological thought of the IM injection, which truthfully doesn’t really hurt. I will continue with this as it’s working, and I am taking my injection on Saturday night. The following day, I am very tired, but it’s Sunday, so a day to relax!"

10 / 10
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4 Report
  • Lin...
  • June 4, 2009

For Multiple Sclerosis "I've been using this medication since February 2009, when I was diagnosed, and I can't complain much. Most problems I have are a small amount of chills after injection the day after, maybe a little tired, but in 1-2 days, I'm good to go. I've found some benefits too, cognition is better, a small difference, but still, it's something. I have a feeling of normality that I've not had in years, not sure if that's the medicine though, or just knowing what the heck has been wrong with me all this time."

9 / 10
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6 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.