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Carbidopa / levodopa User Reviews & Ratings (Page 4)

Brand names: Sinemet, Rytary, Crexont, Parcopa, Duopa, Dhivy Atamet

Carbidopa / levodopa has an average rating of 7.2 out of 10 from a total of 102 reviews on Drugs.com. 62% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Carbidopa / levodopa

Commonly mentioned side effects
  • Jud...
  • Taken for 2 to 5 years
  • July 12, 2025

Carbidopa / levodopa for Parkinson's Disease "The drug works well, however, it cannot be relied upon totally. I take 5 tablets a day: morning, noon, late afternoon, evening, and night. I find absorption depends on how full my stomach is. It can take as little as 1/2 an hour or as much as 2 hours to 'kick' in. The effects last for around 3 hours for the most part, but this also varies. I wish there was another method of taking this medication that did not involve the digestive tract."

6 / 10
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  • wv_...
  • September 4, 2009

Carbidopa / levodopa for Parkinson's Disease "Overall was an effective drug for me, but had problems with it wearing off between doses."

7 / 10
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126 Report
  • Anonymous
  • August 20, 2010

Carbidopa / levodopa for Restless Legs Syndrome "Sinemet works great for my restless legs syndrome, even better than the drugs more popularly prescribed. It is absolutely the one medication I cannot live without!"

10 / 10
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74 Report

Frequently asked questions

  • Ano...
  • Taken for 1 to 6 months
  • April 29, 2018

Carbidopa / levodopa for Parkinson's Disease "I took Sinemet for about a month, and while it lessened my uncoordinated hand movement, I fell into a very deep depression and was having panic attacks. As soon as I stopped taking it, I was better."

2 / 10
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39 Report
  • Anonymous
  • May 15, 2011

Carbidopa / levodopa for Restless Legs Syndrome "It is working great for me, and unlike other medications, it is not a controlled drug nor addicting."

9 / 10
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54 Report

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  • mar...
  • June 5, 2017

Carbidopa / levodopa for Parkinson's Disease "Terrible depression, mood swings, not helping. Tremors seem the same as before I was taking them. Might ask the doctor to stop giving it one more week. I have been taking it for 6 weeks."

1 / 10
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29 Report
  • liz...
  • Taken for 6 months to 1 year
  • October 19, 2015

Carbidopa / levodopa for Restless Legs Syndrome "I have to take more and more. It wears off fast. I also get constipated and itch like crazy from it!"

6 / 10
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28 Report

More FAQ

  • web...
  • November 28, 2011

Carbidopa / levodopa for Parkinson's Disease "I started Sinemet 25/100 mg, and within 2 hrs, my tremor stopped. I still get some, but not as bad as before. My walking also improved."

7 / 10
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33 Report
  • sha...
  • Taken for 1 to 6 months
  • November 30, 2020

Carbidopa / levodopa for Parkinson's Disease "Was having uncontrollable shaking and muscle movement. Started on Rytary 95 mg two times a day. Working great for me. Have reduced shaking and overall muscle movement by about 90%."

10 / 10
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15 Report
  • Ali...
  • Taken for less than 1 month
  • September 17, 2013

For Restless Legs Syndrome "I'm just beginning to use this medication for restless leg syndrome. So far, I have noticed this will help me sleep at night."

9 / 10
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25 Report
  • Cha...
  • June 14, 2017

For Parkinson's Disease "After every dose, have 30 to 45 minutes of extreme tiredness and difficulty thinking. As time goes on, seems to be getting worse. Have not been able to get any answers."

3 / 10
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17 Report
  • mar...
  • December 7, 2009

For Parkinson's Disease "All it took was one dose, and I could walk normally. Minimal side effects after 5 years on it."

10 / 10
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25 Report
  • Mou...
  • Taken for 6 months to 1 year
  • August 31, 2020

For Parkinson's Disease "Carbidopa/levodopa seems to help with my balance and coordination."

7 / 10
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9 Report
  • Anonymous
  • February 15, 2018

For Parkinson's Disease "Do not take this if you have a history of depression. My brother was on for 4 days and became more depressed and suicidal. He is only 55 and never has been suicidal in the past."

1 / 10
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13 Report
  • DOL...
  • Taken for 1 to 6 months
  • December 23, 2019

Carbidopa / levodopa for Parkinson's Disease "Rytary seems to work, but I have morning nausea."

5 / 10
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9 Report
  • ter...
  • August 18, 2010

For Parkinson's Disease "After many medications and several diagnoses, just after one day since I was put on this medication, I feel like part of my life is regained."

10 / 10
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21 Report
  • Max...
  • Taken for 5 to 10 years
  • November 22, 2021

Carbidopa / levodopa for Parkinson's Disease "I have been okay on this. Now getting wear off quickly. But would recommend trying."

10 / 10
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6 Report
  • Anonymous
  • January 10, 2012

For Restless Legs Syndrome "I have had restless legs syndrome for over 15 years. It has gotten worse over the years, but with my doctor increasing my medication, my symptoms have been, for the most part, under control."

10 / 10
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15 Report
  • Leo...
  • Taken for 10 years or more
  • March 11, 2020

For Restless Legs Syndrome "I've taken this med for over 30 yrs. It works!"

10 / 10
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7 Report
  • Joh...
  • December 28, 2011

Carbidopa / levodopa for Restless Legs Syndrome "Watch out for an increase in restless legs syndrome (augmentation) at higher doses. Info I found says it should NOT be taken every day for RLS, not more than 3 times per week."

6 / 10
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20 Report
  • Kel...
  • October 16, 2016

For Restless Legs Syndrome "For several years, I was prescribed Clonazepam, an opiate. Had bad side effects and was very addictive. A new doctor took me off that drug and put me on Sinemet, and it has worked well for my RLS."

9 / 10
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8 Report
  • Vix...
  • Taken for less than 1 month
  • September 22, 2022

For Restless Legs Syndrome "Have had RLS since I was 17 years old. Used Pexola since 2005. I ran out of meds. Carbilev was prescribed. Sorry, no effect, my RLS just increased."

1 / 10
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1 Report
  • Noh...
  • Taken for 1 to 2 years
  • July 4, 2021

For Restless Legs Syndrome "I've tried several levels of Mirapex and found that 3 tablets of Sinemet works best for me."

10 / 10
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1 Report
  • Ano...
  • Taken for 1 to 6 months
  • August 11, 2025

Carbidopa / levodopa for Parkinson's Disease "The medication is more helpful than carbldopa/levodopa, but it is way too expensive. My insurance won't cover it, and I have to pay for it out of pocket."

8 / 10
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0 Report
  • dia...
  • Taken for 2 to 5 years
  • August 18, 2025

For Parkinson's Disease "Have fatigue and insomnia. Have shaky hands. Been on it 3 years. Helped hands and gave a little bit of energy."

4 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.