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Rh Factor Incompatibility


Rh (rhesus) factor incompatibility is a condition that occurs when a mother is Rh negative (Rh-) and her baby is Rh positive (Rh+). Rh factor is a protein found on red blood cells. You are Rh+ if you have this protein and Rh- if you do not have it. Rh incompatibility usually has little effect on your first pregnancy, but can cause problems with future pregnancies.


Follow up with your healthcare provider as directed:

Write down your questions so you remember to ask them during your visits.

Prevent Rh factor incompatibility:

Immune globulin (RhIg) shots may help reduce your risk. These shots prevent your body from making Rh antibodies. RhIg shots are usually given in the 28th week of pregnancy and within 72 hours after giving birth. You may need another shot if you have not given birth within 12 weeks after the first shot. RhIg shots may also be given after an abortion, miscarriage, or abdominal trauma. Shots are also given after any procedure that may cause your baby's blood to leak into your bloodstream. These procedures may include amniocentesis, fetal blood sampling, or a change in the baby's position in the womb before birth.

For support and more information:

  • The American College of Obstetricians and Gynecologists
    P.O. Box 70620
    Washington , DC 20024-9998
    Phone: 1- 202 - 638-5577
    Phone: 1- 800 - 673-8444
    Web Address:

Contact your healthcare provider if:

  • You have a fever.
  • You have severe abdominal pain.
  • You have questions or concerns about your condition or care.

Seek care immediately if:

  • You feel your baby is moving less or is not moving at all.
  • You have trauma, especially to your abdomen, even if you do not feel like you were hurt.
  • You have heavy vaginal bleeding.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Learn more about Rh Factor Incompatibility (Discharge Care)

Associated drugs

IBM Watson Micromedex

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.