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Generic Name: Daclizumab (dac KLYE zue mab)
Brand Name: Zinbryta

Medically reviewed by Last updated on Apr 26, 2020.


  • This medicine can cause very bad liver problems. Sometimes, these have been deadly. Liver problems can happen any time during treatment with Zinbryta (daclizumab). Liver problems have also happened up to 5 months after the last dose of Zinbryta (daclizumab). Do not take Zinbryta (daclizumab) if you have liver problems. Talk with the doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Certain immune system problems can happen with Zinbryta (daclizumab). Some of these may include skin reactions, swollen glands, a certain bowel problem (colitis), and a type of anemia (hemolytic anemia). Some problems took many months to go away after the last dose of Zinbryta (daclizumab) while some problems did not go away. Call your doctor right away if you feel very tired or weak or have a rash or skin irritation; tender, painful, or swollen lymph nodes; pale skin; or shortness of breath. Call your doctor if you have signs of colitis like bloody stools, diarrhea that does not go away, fever, or stomach pain. Call your doctor if you have any new or unexplained health problem.

Uses of Zinbryta:

  • It is used to treat MS (multiple sclerosis).
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Zinbryta?

  • If you have an allergy to daclizumab or any other part of Zinbryta (daclizumab).
  • If you are allergic to Zinbryta (daclizumab); any part of Zinbryta (daclizumab); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have ever had any of these health problems: Autoimmune hepatitis or liver disease.
  • If you have TB (tuberculosis), talk with your doctor.
  • If you have an infection.

This is not a list of all drugs or health problems that interact with Zinbryta (daclizumab).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Zinbryta (daclizumab) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Zinbryta?

  • Tell all of your health care providers that you take Zinbryta (daclizumab). This includes your doctors, nurses, pharmacists, and dentists.
  • Have patient safety card with you at all times.
  • You may need to have a TB (tuberculosis) test before starting Zinbryta (daclizumab).
  • Hepatitis testing needs to be done before taking Zinbryta (daclizumab).
  • Talk with your doctor before getting any vaccines while you take Zinbryta (daclizumab) and after you stop taking it. Vaccine use with Zinbryta (daclizumab) may either raise the chance of an infection or make the vaccine not work as well. Talk with your doctor.
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • Do not give to a child. Talk with your doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Zinbryta (daclizumab) while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Zinbryta) best taken?

Use Zinbryta (daclizumab) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into the fatty part of the skin on the top of the thigh, belly area, or upper arm.
  • If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
  • Before using Zinbryta (daclizumab), take it out of the refrigerator and leave it at room temperature for 30 minutes.
  • Do not heat or microwave.
  • Do not use if the solution is cloudy, leaking, or has particles.
  • This medicine is colorless to a faint yellow. Do not use if the solution changes color.
  • Throw syringe away after use. Do not use the same syringe more than one time.
  • Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it has been 2 weeks or more since the missed dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • If you are not sure what to do if you miss a dose, call your doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of depression, thoughts of suicide, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.

What are some other side effects of Zinbryta?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Nose and throat irritation.
  • Signs of a common cold.
  • Flu-like signs.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Zinbryta?

  • Store in a refrigerator. Do not freeze.
  • Store in original container.
  • Do not use if it has been frozen.
  • If needed, you may store at room temperature for up to 30 days. If stored at room temperature and not used within 30 days, throw Zinbryta (daclizumab) away.
  • Protect from heat.
  • Do not put Zinbryta (daclizumab) back in the refrigerator after it has been stored at room temperature.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Zinbryta (daclizumab) is refilled. If you have any questions about Zinbryta (daclizumab), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Frequently Asked Questions