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Sodium Nitrite and Sodium Thiosulfate

Generic Name: Sodium Nitrite and Sodium Thiosulfate (SOW dee um NYE trite & SOW dee um thye oh SUL fate)
Brand Name: Nithiodote

Medically reviewed on July 4, 2018

Warning

  • This medicine may cause low blood pressure and a red blood cell problem called methemoglobinemia. These may be life-threatening. This medicine is only for use when cyanide poisoning is life-threatening. This medicine must be used with care if it is not known if cyanide poisoning has happened. Talk with the doctor.
  • Tell your doctor if you have inhaled a lot of smoke or if you have any of these health problems: Anemia, heart problems, lack of a certain enzyme called congenital methemoglobin reductase deficiency, or lung problems.

Uses of Sodium Nitrite and Sodium Thiosulfate:

  • It is used to treat cyanide poisoning.

What do I need to tell my doctor BEFORE I take Sodium Nitrite and Sodium Thiosulfate?

  • If you have an allergy to sodium nitrite, sodium thiosulfate, or any other part of sodium nitrite and sodium thiosulfate.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take sodium nitrite and sodium thiosulfate with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Sodium Nitrite and Sodium Thiosulfate?

  • Tell all of your health care providers that you take sodium nitrite and sodium thiosulfate. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Have your blood pressure checked often. Talk with your doctor.
  • Be careful if you have G6PD deficiency. Anemia may happen.
  • Use with care in children younger than 6 months old. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using sodium nitrite and sodium thiosulfate while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Sodium Nitrite and Sodium Thiosulfate) best taken?

Use sodium nitrite and sodium thiosulfate as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of methemoglobinemia like a blue or gray color of the lips, nails, or skin; a heartbeat that does not feel normal; seizures; very bad dizziness or passing out; very bad headache; feeling very sleepy; feeling tired or weak; or shortness of breath. This effect is rare but may be deadly if it happens.
  • Signs of too much acid in the blood (acidosis) like confusion; fast breathing; fast heartbeat; a heartbeat the does not feel normal; very bad stomach pain, upset stomach, or throwing up; feeling very sleepy; shortness of breath; or feeling very tired or weak.
  • Very bad dizziness or passing out.
  • A fast heartbeat.
  • A heartbeat that does not feel normal.
  • Feeling confused.
  • Blurred eyesight.
  • Seizures.
  • Numbness and tingling.
  • Fast breathing.
  • Shortness of breath.

What are some other side effects of Sodium Nitrite and Sodium Thiosulfate?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Flushing.
  • Headache.
  • Upset stomach or throwing up.
  • Belly pain.
  • Bad taste in your mouth.
  • Anxiety.
  • Sweating a lot.
  • Feeling tired or weak.
  • Feeling of warmth.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Sodium Nitrite and Sodium Thiosulfate?

  • If you need to store sodium nitrite and sodium thiosulfate at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about sodium nitrite and sodium thiosulfate, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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