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Generic Name: sodium nitrite and sodium thiosulfate (SOO dee um NYE trite and SOO de um THYE oh SUL fate)
Brand Name: Nithiodote

What is Nithiodote?

Nithiodote is a combination medicine that is used as an antidote to cyanide poisoning. This medicine works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.

Nithiodote is used in an emergency to treat cyanide poisoning. This type of poisoning can occur if you are exposed to smoke from a house or industrial fire, if you swallow or breathe in cyanide, or if you get cyanide on your skin.

Nithiodote may also be used for purposes not listed in this medication guide.

Important Information

If possible before you receive Nithiodote, tell your caregivers if you have anemia, low blood pressure, or heart disease.

In an emergency situation it may not be possible before you are treated to tell your caregivers about your health conditions or if you are pregnant or breast feeding. Make sure any doctor caring for you afterward knows that you have received this medication.

Before taking this medicine

If possible before you receive Nithiodote, tell your caregivers if you have:

  • anemia (low red blood cells);

  • a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency;

  • low blood pressure; or

  • heart disease.

FDA pregnancy category C. Tell your doctor if you are pregnant. It is not known whether Nithiodote will harm an unborn baby. However, the benefits of treating cyanide poisoning may outweigh any risks posed by this medication, for both you and your baby.

It is not known whether this medication passes into breast milk or if it could harm a nursing baby. You should not breast-feed shortly after you have been treated with Nithiodote. Ask your doctor how long you should wait before breast-feeding again. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

In an emergency situation, it may not be possible before you are treated with Nithiodote to tell your caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medication.

How is sodium nitrite and sodium thiosulfate given?

This medication is injected into a vein through an IV. You will receive this injection in a clinic or emergency setting.

Nithiodote are given as two separate injections.

Your breathing, blood pressure, oxygen levels, heart function, and other vital signs will be watched closely while you are receiving Nithiodote.

What happens if I miss a dose?

Since Nithiodote is given by a healthcare professional in an emergency setting, you are not likely to miss a dose.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving Nithiodote?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Nithiodote side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; chest tightness, difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have a serious side effect such as:

  • feeling like you might pass out;

  • headache, tired feeling, blue-colored skin, feeling short of breath;

  • fast or irregular heart rate; or

  • pounding heartbeats or fluttering in your chest.

Less serious side effects may include:

  • mild dizziness;

  • blurred vision;

  • confusion, anxiety, sweating;

  • nausea, vomiting, stomach pain;

  • salty taste in your mouth;

  • feeling of warmth; or

  • tingly feeling where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Nithiodote?

If possible before you receive this medication, tell your doctor about all other medicines you use, especially:

There may be other drugs that can interact with Nithiodote. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Nithiodote.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.02.

Date modified: February 01, 2018
Last reviewed: December 03, 2013