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Generic name: sodium nitrite and sodium thiosulfateSOO-dee-um-NYE-trite-and-SOO-de-um-THYE-oh-SUL-fate ]
Drug class: Antidotes

Medically reviewed by on Mar 21, 2023. Written by Cerner Multum.

What is Nithiodote?

Nithiodote is a combination medicine that is used in an emergency to treat cyanide poisoning. This type of poisoning can occur if you are exposed to smoke from a house or industrial fire, if you swallow or breathe in cyanide, or if you get cyanide on your skin.

Nithiodote helps cells in the body convert cyanide to a form that can be removed through urination.

Nithiodote may also be used for purposes not listed in this medication guide.

Nithiodote side effects

Get emergency medical help if you have signs of an allergic reaction: hives; chest tightness, difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • a light-headed feeling, like you might pass out;

  • a seizure;

  • shortness of breath, tiredness;

  • fast or irregular heart rate, pounding heartbeats or fluttering in your chest; or

  • signs of a blood cell disorder--nausea, vomiting, dizziness, muscle weakness, loss of coordination, blue-colored skin, feeling tired or short of breath.

Common side effects of Nithiodote may include:

  • feeling light-headed, loss of consciousness;

  • headache, dizziness, confusion;

  • blurred vision; or

  • fast or pounding heartbeats.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received Nithiodote.

Before taking this medicine

If possible before you receive this medicine, tell your caregivers if you have ever had:

In an emergency, you may not be able to tell caregivers if you are pregnant or breastfeeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.

You should not breastfeed while using Nithiodote.

How is Nithiodote given?

Nithiodote is given as an infusion into a vein. A healthcare provider will give you this injection.

Nithiodote is usually given as two separate injections.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely.

What happens if I miss a dose?

Because you will receive Nithiodote in an emergency setting, you are not likely to miss a dose.

What happens if I overdose?

Since Nithiodote is given in a medical setting, you will be watched closely to make sure you do not receive too much of Nithiodote. Your caregivers will quickly treat you if you have overdose symptoms.

What should I avoid after receiving Nithiodote?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Nithiodote?

If possible before you receive Nithiodote, tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect Nithiodote, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.