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Nithiodote Side Effects

Generic Name: sodium nitrite / sodium thiosulfate

Note: This document contains side effect information about sodium nitrite / sodium thiosulfate. Some of the dosage forms listed on this page may not apply to the brand name Nithiodote.

For the Consumer

Applies to sodium nitrite / sodium thiosulfate: intravenous solution

Along with its needed effects, sodium nitrite / sodium thiosulfate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sodium nitrite / sodium thiosulfate:

Incidence not known
  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • blurred vision
  • change in consciousness
  • confusion
  • dark urine
  • difficult or labored breathing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • fainting
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • lightheadedness
  • loss of consciousness
  • nausea
  • numbness and tingling sensation
  • pale skin
  • rapid heart rate
  • rapid shallow breathing
  • seizures
  • shortness of breath
  • sore throat
  • sweating
  • tightness in the chest
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • wheezing

Some side effects of sodium nitrite / sodium thiosulfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Abdominal or stomach pain
  • anxiety
  • confusion about identity, place, and time
  • headache
  • hives or welts
  • increased sweating
  • itching
  • redness of the skin
  • salty taste in your mouth
  • skin rash
  • tingling sensation at the injection site
  • warm sensation over your body

For Healthcare Professionals

Applies to sodium nitrite / sodium thiosulfate: intravenous solution


Cardiovascular side effects have included syncope, hypotension, tachycardia, palpitations, and dysrhythmia[Ref]


Hematologic side effects have included methemoglobinemia and prolonged bleeding time.[Ref]

Nervous system

Nervous system side effects have included headache, dizziness, blurred vision, seizures, confusion, coma, anxiety, lightheadedness, fatigue, weakness, disorientation, generalized numbness and tingling.[Ref]


Gastrointestinal side effects have included nausea, vomiting, abdominal pain, and salty taste in mouth.[Ref]


Respiratory side effects have included tachypnea, cyanosis, and dyspnea.[Ref]


Dermatologic side effects have included urticaria, diaphoresis, and a warm sensation over the body.[Ref]


Local side effects have included injection site tingling.[Ref]


1. "Product Information. Nithiodote (sodium nitrite-sodium thiosulfate)." Hope Pharmaceuticals, Scottsdale, AZ.

Some side effects of Nithiodote may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.