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Nithiodote Side Effects

Generic Name: sodium nitrite / sodium thiosulfate

Note: This document contains side effect information about sodium nitrite / sodium thiosulfate. Some of the dosage forms listed on this page may not apply to the brand name Nithiodote.

For the Consumer

Applies to sodium nitrite / sodium thiosulfate: intravenous solution

Along with its needed effects, sodium nitrite / sodium thiosulfate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sodium nitrite / sodium thiosulfate:

Incidence not known
  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • blurred vision
  • change in consciousness
  • confusion
  • dark urine
  • difficult or labored breathing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • fainting
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • lightheadedness
  • loss of consciousness
  • nausea
  • numbness and tingling sensation
  • pale skin
  • rapid heart rate
  • rapid shallow breathing
  • seizures
  • shortness of breath
  • sore throat
  • sweating
  • tightness in the chest
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • wheezing

Some side effects of sodium nitrite / sodium thiosulfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Abdominal or stomach pain
  • anxiety
  • confusion about identity, place, and time
  • headache
  • hives or welts
  • increased sweating
  • itching
  • redness of the skin
  • salty taste in your mouth
  • skin rash
  • tingling sensation at the injection site
  • warm sensation over your body

For Healthcare Professionals

Applies to sodium nitrite / sodium thiosulfate: intravenous solution

Cardiovascular

Cardiovascular side effects have included syncope, hypotension, tachycardia, palpitations, and dysrhythmia[Ref]

Hematologic

Hematologic side effects have included methemoglobinemia and prolonged bleeding time.[Ref]

Nervous system

Nervous system side effects have included headache, dizziness, blurred vision, seizures, confusion, coma, anxiety, lightheadedness, fatigue, weakness, disorientation, generalized numbness and tingling.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, abdominal pain, and salty taste in mouth.[Ref]

Respiratory

Respiratory side effects have included tachypnea, cyanosis, and dyspnea.[Ref]

Dermatologic

Dermatologic side effects have included urticaria, diaphoresis, and a warm sensation over the body.[Ref]

Local

Local side effects have included injection site tingling.[Ref]

References

1. "Product Information. Nithiodote (sodium nitrite-sodium thiosulfate)." Hope Pharmaceuticals, Scottsdale, AZ.

Some side effects of Nithiodote may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

More about Nithiodote (sodium nitrite / sodium thiosulfate)

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