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Nithiodote Side Effects

Generic Name: sodium nitrite / sodium thiosulfate

Note: This document contains side effect information about sodium nitrite / sodium thiosulfate. Some of the dosage forms listed on this page may not apply to the brand name Nithiodote.

For the Consumer

Applies to sodium nitrite / sodium thiosulfate: intravenous solution

Along with its needed effects, sodium nitrite/sodium thiosulfate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sodium nitrite / sodium thiosulfate:

Incidence Not Known

  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • blurred vision
  • change in consciousness
  • confusion
  • dark urine
  • difficult or labored breathing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • fainting
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • lightheadedness
  • loss of consciousness
  • nausea
  • numbness and tingling sensation
  • pale skin
  • rapid heart rate
  • rapid shallow breathing
  • seizures
  • shortness of breath
  • sore throat
  • sweating
  • tightness in the chest
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • wheezing

Some side effects of sodium nitrite / sodium thiosulfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence Not Known

  • Abdominal or stomach pain
  • anxiety
  • confusion about identity, place, and time
  • headache
  • hives or welts
  • increased sweating
  • itching
  • redness of the skin
  • salty taste in your mouth
  • skin rash
  • tingling sensation at the injection site
  • warm sensation over your body

For Healthcare Professionals

Applies to sodium nitrite / sodium thiosulfate: intravenous solution

Cardiovascular

Frequency not reported: Hypotension, tachycardia, palpitations, dysrhythmia, severe hypotension, cyanosis[Ref]

Hematologic

Frequency not reported: Methemoglobinemia, prolonged bleeding time[Ref]

Nervous system

Frequency not reported: Syncope, headache, dizziness, seizures, confusion, coma, lightheadedness, generalized numbness and tingling, salty taste in mouth, warm sensation over body[Ref]

Respiratory

Frequency not reported: Tachypnea, dyspnea[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, abdominal pain[Ref]

Dermatologic

Frequency not reported: Urticaria, diaphoresis[Ref]

Other

Frequency not reported: Fatigue, weakness, death

Local

Frequency not reported: Injection site tingling[Ref]

Psychiatric

Frequency not reported: Anxiety, confusion, disorientation

Metabolic

Frequency not reported: Acidosis

Ocular

Frequency not reported: Blurred vision

References

1. "Product Information. Nithiodote (sodium nitrite-sodium thiosulfate)." Hope Pharmaceuticals, Scottsdale, AZ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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