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Sodium nitrite / sodium thiosulfate Side Effects

For the Consumer

Applies to sodium nitrite / sodium thiosulfate: intravenous solution

As well as its needed effects, sodium nitrite / sodium thiosulfate may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking sodium nitrite / sodium thiosulfate, check with your doctor or nurse immediately:

Incidence not known:
  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • blurred vision
  • change in consciousness
  • confusion
  • dark urine
  • difficult or labored breathing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • fainting
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • lightheadedness
  • loss of consciousness
  • nausea
  • numbness and tingling sensation
  • pale skin
  • rapid heart rate
  • rapid shallow breathing
  • seizures
  • shortness of breath
  • sore throat
  • sweating
  • tightness in the chest
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • wheezing

Minor Side Effects

Some sodium nitrite / sodium thiosulfate side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:
  • Abdominal or stomach pain
  • anxiety
  • confusion about identity, place, and time
  • headache
  • hives or welts
  • increased sweating
  • itching
  • redness of the skin
  • salty taste in your mouth
  • skin rash
  • tingling sensation at the injection site
  • warm sensation over your body

For Healthcare Professionals

Applies to sodium nitrite / sodium thiosulfate: intravenous solution

Cardiovascular

Cardiovascular side effects have included syncope, hypotension, tachycardia, palpitations, and dysrhythmia[Ref]

Hematologic

Hematologic side effects have included methemoglobinemia and prolonged bleeding time.[Ref]

Nervous system

Nervous system side effects have included headache, dizziness, blurred vision, seizures, confusion, coma, anxiety, lightheadedness, fatigue, weakness, disorientation, generalized numbness and tingling.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, abdominal pain, and salty taste in mouth.[Ref]

Respiratory

Respiratory side effects have included tachypnea, cyanosis, and dyspnea.[Ref]

Dermatologic

Dermatologic side effects have included urticaria, diaphoresis, and a warm sensation over the body.[Ref]

Local

Local side effects have included injection site tingling.[Ref]

References

1. "Product Information. Nithiodote (sodium nitrite-sodium thiosulfate)." Hope Pharmaceuticals, Scottsdale, AZ.

It is possible that some side effects of sodium nitrite / sodium thiosulfate may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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