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Sodium Nitrite/Sodium Thiosulfate Dosage

Medically reviewed by Drugs.com. Last updated on Mar 21, 2023.

Applies to the following strengths: 30 mg-250 mg/mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cyanide Poisoning

Sodium Nitrite: 300 mg (10 mL) intravenously (IV) at a rate of 2.5 to 5 mL/minute
Sodium Thiosulfate: 12.5 grams (50 mL), slow IV, immediately following sodium nitrite administration


Comments:

Use(s): Acute cyanide poisoning that is judged to be serious or life-threatening.

Usual Pediatric Dose for Cyanide Poisoning

Sodium Nitrite: 0.2 mL/kg (6 mg/kg or 6 to 8 mL/m2 BSA) intravenously (IV) at a rate of 2.5 to 5 mL/minute
Maximum dose: 300 mg (10 mL)
Sodium Thiosulfate: 250 mg/kg (1 mL/kg or approximately 30 to 40 mL/m2 BSA), slow IV, immediately following sodium nitrite administration
Maximum dose: 12.5 grams (50 mL)


Comments:

Use(s): Acute cyanide poisoning that is judged to be serious or life-threatening.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

US BOXED WARNING(S):
LIFE THREATENING HYPOTENSION AND METHEMOGLOBIN FORMATION


CONTRAINDICATIONS: None

Healthcare professionals are asked to report any suspected adverse reactions at www.fda.gov/medwatch.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


IV compatibility:

Monitoring:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.