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Riboflavin 5'-Phosphate

Generic name: Riboflavin 5'-Phosphate [ RYE-boe-flay-vin-five-FOS-fate ]
Brand names: Photrexa Viscous, Photrexa-Photrexa Viscous Kit
Drug class: Miscellaneous ophthalmic agents

Medically reviewed by Last updated on May 13, 2023.

Uses of Riboflavin 5'-Phosphate:

  • It is used to treat an eye problem called keratoconus.
  • It is used to treat certain eye problems after eye surgery.

What do I need to tell my doctor BEFORE I take Riboflavin 5'-Phosphate?

  • If you are allergic to riboflavin 5'-phosphate; any part of riboflavin 5'-phosphate; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you are pregnant or may be pregnant. Do not use riboflavin 5'-phosphate if you are pregnant.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take riboflavin 5'-phosphate with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Riboflavin 5'-Phosphate?

  • Tell all of your health care providers that you take riboflavin 5'-phosphate. This includes your doctors, nurses, pharmacists, and dentists.
  • Use care when driving or doing other tasks that call for clear eyesight.
  • Bright lights may bother you. Wear sunglasses.
  • Do not rub your eyes for the first 5 days after your treatment.
  • If the bandage contact lens that was placed the day of treatment falls out or moves, do not put it back. Call the doctor right away.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Riboflavin 5'-Phosphate) best taken?

Use riboflavin 5'-phosphate as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • For the eye only.
  • Your doctor will give riboflavin 5'-phosphate.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Very bad eye irritation.
  • Very bad eye pain.
  • Sudden change in eyesight.

What are some other side effects of Riboflavin 5'-Phosphate?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Change in eyesight.
  • Eye pain.
  • Eye irritation.
  • Seeing floaters.
  • Dry eyes.
  • Feeling that something is in the eye.
  • More tears.
  • Headache.
  • If bright lights bother your eyes.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Riboflavin 5'-Phosphate?

  • If you need to store riboflavin 5'-phosphate at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about riboflavin 5'-phosphate, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.