Generic Name: Pexidartinib (pex i DAR ti nib)
Brand Name: Turalio
Medically reviewed by Drugs.com. Last updated on Jul 28, 2020.
- Severe liver problems have happened with pexidartinib. These liver problems can be deadly. Have your blood work checked as you have been told by your doctor.
- Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
Uses of Pexidartinib:
- It is used to treat a type of cancer called tenosynovial giant cell tumor (TGCT).
What do I need to tell my doctor BEFORE I take Pexidartinib?
- If you are allergic to pexidartinib; any part of pexidartinib; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have liver disease or raised liver enzymes.
- If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with pexidartinib, like some other drugs used for HIV or certain drugs used for seizures, infection, or stomach or bowel problems. There are many drugs that must not be taken with this drug.
- If you are taking St. John's wort. Do not take St. John's wort with pexidartinib. This medicine may not work as well.
- If you are taking any drugs that can raise the chance of liver problems. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
- If you are breast-feeding. Do not breast-feed while you take pexidartinib and for 1 week after your last dose.
This is not a list of all drugs or health problems that interact with pexidartinib.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take pexidartinib with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Pexidartinib?
- Tell all of your health care providers that you take pexidartinib. This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- High cholesterol has happened with pexidartinib. If you have questions, talk with the doctor.
- Avoid grapefruit and grapefruit juice.
- This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child.
- This medicine may cause harm to an unborn baby. A pregnancy test will be done before you start pexidartinib to show that you are NOT pregnant.
- Women must use birth control while taking pexidartinib and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.
- Men with a partner who may get pregnant must use birth control while taking pexidartinib and for some time after the last dose. Ask your doctor how long to use birth control. If your partner gets pregnant, call the doctor right away.
How is this medicine (Pexidartinib) best taken?
Use pexidartinib as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take pexidartinib on an empty stomach. Take at least 1 hour before or at least 2 hours after a meal.
- Swallow whole. Do not chew, open, or crush.
- Keep taking pexidartinib as you have been told by your doctor or other health care provider, even if you feel well.
- Do not take antacids within 2 hours before or 2 hours after taking pexidartinib.
- Do not take cimetidine, famotidine, nizatidine, or ranitidine at the same time as pexidartinib. Take pexidartinib at least 2 hours before or 10 hours after taking these drugs.
- If you throw up after taking a dose, do not repeat the dose. Take your next dose at your normal time.
What do I do if I miss a dose?
- Skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Signs of low phosphate levels like change in eyesight, feeling confused, mood changes, muscle pain or weakness, shortness of breath or other breathing problems, or trouble swallowing.
- Swelling in the arms or legs.
- Swelling in or around the eyes.
- A burning, numbness, or tingling feeling that is not normal.
- Low blood cell counts have happened with pexidartinib. If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. Call your doctor right away if you have signs of infection like fever, chills, or sore throat; any unexplained bruising or bleeding; or if you feel very tired or weak.
What are some other side effects of Pexidartinib?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Change in color of hair.
- Feeling tired or weak.
- Change in taste.
- Throwing up.
- Not hungry.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Pexidartinib?
- Store at room temperature.
- Store in the original container. Do not take out the antimoisture cube or packet.
- Keep lid tightly closed.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time pexidartinib is refilled. If you have any questions about pexidartinib, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about pexidartinib
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- En Español
- Drug class: multikinase inhibitors
Other brands: Turalio