Generic Name: maraviroc (MAR-a-VIR-ok)
Brand Name: Selzentry
Liver problems have been reported in some patients taking maraviroc. An allergic reaction may occur before liver problems develop. Contact your doctor right away if you develop a rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; yellowing of the eyes or skin; dark urine; pale stools; loss of appetite; or severe stomach pain.
Maraviroc is used for:
Treating patients with a certain type of HIV infection (CCR5-tropic HIV-1). It is used along with other HIV medicines.
Maraviroc is a CCR5 coreceptor antagonist. It works by blocking the virus from entering cells.
Do NOT use maraviroc if:
- you are allergic to any ingredient in maraviroc
- you are taking St. John's wort
- you have severe kidney problems or you are on dialysis and you take certain other medicines. Talk to your doctor before taking maraviroc if you have kidney problems
Contact your doctor or health care provider right away if any of these apply to you.
Before using maraviroc:
Some medical conditions may interact with maraviroc. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of liver problems (eg, hepatitis B or C), or kidney problems
- if you have a history of heart problems, or if you are at risk of heart problems
- if you are on dialysis
- if you have a history of low blood pressure or dizziness when you stand up
- if you are taking medicine to lower your blood pressure
Some MEDICINES MAY INTERACT with maraviroc. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Azole antifungals (eg, itraconazole, ketoconazole), delavirdine, macrolide antibiotics (eg, clarithromycin), nefazodone, protease inhibitors (eg, amprenavir, boceprevir, ritonavir), or telithromycin because they may increase the risk of maraviroc's side effects
- Barbiturates (eg, phenobarbital), carbamazepine, efavirenz, etravirine, hydantoins (eg, phenytoin), rifamycins (eg, rifampin), or St. John's wort because they may decrease maraviroc's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if maraviroc may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use maraviroc:
Use maraviroc as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Maraviroc comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get maraviroc refilled.
- Take maraviroc by mouth with or without food.
- Swallow maraviroc whole. Do not break, crush, or chew before swallowing.
- Taking maraviroc at the same time(s) each day will help you remember to take it.
- Take maraviroc on a regular schedule to get the most benefit from it.
- Continue to take maraviroc even if you feel well. Do not miss any doses.
- If you miss a dose of maraviroc, take it as soon as possible. If your next dose is less than 6 hours away, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use maraviroc.
Important safety information:
- Maraviroc may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use maraviroc with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Maraviroc may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. Your risk may be greater if you have severe kidney problems. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor.
- Certain other medicines for HIV (eg, HIV protease inhibitors, delavirdine, efavirenz) may increase the side effects of maraviroc or decrease its effectiveness. Talk with your doctor about all of your HIV medicines. Do not start, stop, or change the dose of any HIV medicine unless your doctor tells you to.
- Serious and sometimes fatal skin reactions and allergic reactions have been reported in some patients taking maraviroc. Contact your doctor right away if you develop blisters or sores in the mouth; fever; general ill feeling; muscle or joint aches; rash, including red, swollen, blistered, or peeling skin; red or swollen eyes; severe tiredness; trouble breathing; swelling of the mouth or face; symptoms of kidney problems (eg, decreased urination); or symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, severe or persistent nausea or vomiting, stomach pain, yellowing of the eyes or skin).
- Maraviroc may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start maraviroc.
- Maraviroc may increase the risk of developing an infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills. Discuss any questions or concerns with your doctor.
- It is possible that maraviroc may increase the risk of developing cancer. No increase in cancer cases has been seen in patients who take maraviroc. Discuss any questions or concerns with your doctor.
- Maraviroc is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.
- When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking maraviroc, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
- Maraviroc does not stop the spread of HIV to others through blood or sexual contact. Do not have any kind of sex without protection (eg, latex or polyurethane condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HIV to others.
- Lab tests, including liver function, may be performed while you use maraviroc. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Maraviroc should not be used in CHILDREN younger than 16 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using maraviroc while you are pregnant. It is not known if this medicine is found in breast milk. Women infected with HIV should not breast-feed. There is a risk of passing the HIV infection or maraviroc to the baby.
Possible side effects of maraviroc:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; cough; diarrhea; dizziness; muscle or joint pain; runny or stuffy nose; sinus inflammation; stomach pain; trouble sleeping.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; burning, numbness, or tingling; chest, jaw, or arm pain; confusion; depression; difficult or painful urination; fainting; fever, chills, or sore throat; flu-like symptoms; one-sided weakness; red, swollen, blistered, or peeling skin; seizures; severe muscle pain; severe or persistent dizziness; severe or persistent stomach pain; shortness of breath; slurred speech; sores or white patches in the mouth; sudden, severe nausea or vomiting; sudden, unusual sweating or weakness; swelling of the hands, ankles, legs, or feet; symptoms of liver problems (eg, yellowing of the eyes or skin, dark urine, pale stools, loss of appetite, nausea, unusual tiredness, vomiting); unusual lumps, skin growths, or skin changes; unusual tiredness or weakness; vision changes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe or persistent dizziness.Proper storage of maraviroc:
Store maraviroc between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep maraviroc out of the reach of children and away from pets.
- If you have any questions about maraviroc, please talk with your doctor, pharmacist, or other health care provider.
- Maraviroc is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take maraviroc or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about maraviroc. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to maraviroc. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using maraviroc.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about maraviroc
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 2 Reviews – Add your own review/rating
- Drug class: chemokine receptor antagonist
Other brands: Selzentry