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Generic Name: gadopentetate dimeglumine (GAD-oh-PEN-te-tate di-ME-gloo-meen)
Brand Name: Magnevist

Magnevist increases the risk of a possibly severe and sometimes fatal condition called nephrogenic systemic fibrosis in certain patients with kidney problems. Nephrogenic systemic fibrosis results in thickening or hardening (fibrosis) of tissues in the body (eg, skin, muscle, internal organs). Before you receive Magnevist, tell your doctor if you have a history of kidney or liver problems, liver transplant, or if you receive dialysis. Your doctor may need to perform kidney function tests before you receive Magnevist. Tell your doctor right away if you develop joint stiffness; red or dark patches, pain, burning, or swelling of the skin; scaling, hardening, or thickening of the skin; skin lesions; or muscle pain or weakness.

Magnevist is used for:

Providing a better picture with magnetic resonance imaging (MRI).

Magnevist is a diagnostic aid. When used with an MRI, it works by aiding in the detection of abnormalities in the brain, spinal cord, or whole body.

Do NOT use Magnevist if:

  • you are allergic to any ingredient in Magnevist
  • you have kidney injury or severe kidney problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Magnevist:

Some medical conditions may interact with Magnevist. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances (including contrast agents)
  • if you have a history of high blood pressure, diabetes, kidney or liver problems, liver transplant, or if you receive dialysis
  • if you have asthma, blood problems (eg, blood clots, blood clotting problems, hemolysis, sickle cell anemia, other anemias), breathing problems, heart problems, or seizures
  • if you have previously received a contrast agent

Some MEDICINES MAY INTERACT with Magnevist. However, no specific interactions with Magnevist are known at this time.

Ask your health care provider if Magnevist may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Magnevist:

Use Magnevist as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Magnevist is usually given as an injection at your doctor's office, hospital, or clinic.
  • Do not use Magnevist if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • If you miss a dose of Magnevist, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Magnevist.

Important safety information:

  • Magnevist may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Magnevist with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Magnevist should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Magnevist while you are pregnant. Magnevist is found in breast milk. If you are or will be breast-feeding while you are using Magnevist, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Magnevist:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; minor pain, swelling, coldness, or redness at the injection site; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); changes in vision; fainting; fast or irregular heartbeat; fever or chills; joint stiffness; muscle weakness; numbness in an arm or leg; red or dark patches, pain, burning, or swelling of the skin; scaling, hardening, or tightening of the skin; seizures; severe stomach pain; sharp or crushing chest pain; skin lesions; sudden leg pain; sudden, severe headache; sudden shortness of breath; tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Magnevist:

Magnevist is usually handled and stored by a health care provider. If you are using Magnevist at home, store Magnevist as directed by your pharmacist or health care provider. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Magnevist out of the reach of children and away from pets.

General information:

  • If you have any questions about Magnevist, please talk with your doctor, pharmacist, or other health care provider.
  • Magnevist is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Magnevist. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Review Date: July 5, 2017

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.