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Generic Name: Iohexol (eye oh HEX ole)
Brand Name: Omnipaque

Medically reviewed on September 5, 2018


  • Some products must not be given into the spine. Very bad and sometimes deadly health problems have happened when these products were given into the spine. This includes coma, heart attack, kidney failure, paralysis, seizures, high body temperature, a muscle problem called rhabdomyolysis, or brain problems like bleeding or swelling. Talk with the doctor.

Uses of Iohexol:

  • It is used before an x-ray or an alike test.

What do I need to tell my doctor BEFORE I take Iohexol?

All products:

  • If you have an allergy to iohexol or any other part of iohexol.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you are dehydrated, have been eating poorly, or have used a laxative or water pill before iohexol.
  • If you have had a skin reaction to iohexol or another drug like it in the past.
  • If you are taking metformin, talk with doctor.

Injection (if given into the spine):

  • If you have an infection.
  • If you are taking any drugs that may raise the chance of seizures, or if you have taken one in the last 48 hours. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.

Injection (if given in an artery or vein):

  • If you are not able to pass urine.

If used before an x-ray of the uterus and fallopian tubes:

  • If you are having your menstrual period or you have a genital infection.
  • If you have had a type of tissue taken out (curettage) or a type of cervix biopsy (conization) within the past 30 days.
  • If you have had a pregnancy ended within the past 6 months.
  • If you are pregnant or may be pregnant. Do not take iohexol if you are pregnant.

This is not a list of all drugs or health problems that interact with iohexol.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take iohexol with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Iohexol?

All products:

  • Tell all of your health care providers that you take iohexol. This includes your doctors, nurses, pharmacists, and dentists.
  • Your blood work may need to be checked. Talk with your doctor.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take iohexol.
  • Very bad and sometimes deadly allergic reactions have rarely happened. Talk with your doctor.
  • If you are 65 or older, use iohexol with care. You could have more side effects.
  • Use with care in children. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using iohexol while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Injection (if given in an artery or vein):

  • Thyroid problems have happened after use of iohexol. Some people had to be treated for these thyroid problems. Talk with the doctor.
  • If you have sickle cell disease, talk with your doctor.
  • Rarely, life-threatening or deadly heart problems have happened with iohexol. This includes low blood pressure and heart attack. Talk with the doctor.
  • A very bad and sometimes deadly reaction has happened with iohexol. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Talk with the doctor.
  • Health problems like blood clots have happened with iohexol when used with some procedures. Sometimes, blood clots may cause heart attack and stroke, which may be deadly. If you have questions, talk with the doctor.

Injection (if given into the spine):

  • This medicine may raise the chance of seizures in some people, including people who have had seizures in the past. Talk to your doctor to see if you have a greater chance of seizures while taking iohexol.

How is this medicine (Iohexol) best taken?

Use iohexol as ordered by your doctor. Read all information given to you. Follow all instructions closely.

All products:

  • You will need to be sure that you are not dehydrated before getting iohexol. Check with your doctor to see if you need to drink extra fluids before getting iohexol.
  • Drink lots of noncaffeine liquids after using iohexol unless told to drink less liquid by your doctor.


  • Your doctor will give iohexol.
  • Other drugs may be given before iohexol to help avoid side effects.


  • It may be given by mouth or given rectally.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

All products:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.


  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Chest pain or pressure.
  • A heartbeat that does not feel normal.
  • Very bad dizziness or passing out.
  • Shortness of breath, a big weight gain, or swelling in the arms or legs.
  • Seizures.
  • Very bad headache.
  • Change in eyesight.
  • This medicine may cause tissue damage if the drug leaks from the vein. Tell your nurse if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your body.
  • Very bad skin reactions (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen from 1 hour to several weeks after getting this drug. These skin reactions can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

Injection (if given into the spine):

  • A burning, numbness, or tingling feeling that is not normal.


  • Swelling.

What are some other side effects of Iohexol?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All products:


  • Change in taste.
  • Dizziness.

Injection (if given in an artery or vein):

  • Feeling of warmth.
  • Change in taste.

Injection (if given into the spine):


  • Loose stools (diarrhea).
  • Belly pain.
  • Gas.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Iohexol?

  • If you need to store iohexol at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about iohexol, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.