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Echothiophate Iodide

Generic name: Echothiophate Iodide [ ek-oh-THYE-oh-fate-EYE-oh-dide ]
Brand name: Phospholine Iodide
Drug class: Ophthalmic glaucoma agents

Medically reviewed by Last updated on Jul 3, 2023.

Uses of Echothiophate Iodide:

  • It is used to lower high eye pressure.
  • It is used to treat cross-eyed children.

What do I need to tell my doctor BEFORE I take Echothiophate Iodide?

  • If you have an allergy to echothiophate iodide or any other part of echothiophate iodide.
  • If you are allergic to echothiophate iodide; any part of echothiophate iodide; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have narrow-angle glaucoma.
  • If you have swelling in parts of the eye.
  • If you are breast-feeding or plan to breast-feed.

This is not a list of all drugs or health problems that interact with echothiophate iodide.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take echothiophate iodide with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Echothiophate Iodide?

  • Tell all of your health care providers that you take echothiophate iodide. This includes your doctors, nurses, pharmacists, and dentists.
  • Use care when driving or doing other tasks that call for clear eyesight.
  • Have your eye pressure checked. Talk with your doctor.
  • Have an eye exam as you have been told by your doctor.
  • If you are around certain insecticides and pesticides, you may have more side effects. If you are around insecticides and pesticides, be sure to wear a breathing mask, and wash and change your clothes often. Talk with your doctor.
  • Use with care in children. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using echothiophate iodide while you are pregnant.

How is this medicine (Echothiophate Iodide) best taken?

Use echothiophate iodide as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • For the eye only.
  • Wash your hands before and after use.
  • Do not touch the container tip to the eye, lid, or other skin.
  • Tilt your head back and drop drug into the eye.
  • After use, keep your eyes closed. Put pressure on the inside corner of the eye. Do this for 1 to 2 minutes. This keeps the drug in your eye.
  • Blot extra solution from the eyelid.
  • Use as you have been told, even if your signs get better.

What do I do if I miss a dose?

  • Use a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not use 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Change in eyesight, eye pain, or very bad eye irritation.
  • Fast or slow heartbeat.
  • A heartbeat that does not feel normal.
  • Diarrhea.
  • Not able to control bladder.
  • More saliva.
  • Muscle weakness.
  • Sweating a lot.
  • Shortness of breath.

What are some other side effects of Echothiophate Iodide?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Eye irritation.
  • Burning.
  • Stinging.
  • Tearing.
  • Eye redness.
  • Blurred eyesight.
  • Eyelid twitching.
  • Headache.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Echothiophate Iodide?

  • Before mixing, store in the refrigerator.
  • After mixing, store at room temperature. Do not refrigerate. Throw away any part not used after 4 weeks.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about echothiophate iodide, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.