Dolutegravir and Rilpivirine
Generic Name: Dolutegravir and Rilpivirine (doe loo TEG ra vir & ril pi VIR een)
Brand Name: Juluca
Medically reviewed by Drugs.com. Last updated on Sep 24, 2019.
Uses of Dolutegravir and Rilpivirine:
- It is used to treat HIV infection.
What do I need to tell my doctor BEFORE I take Dolutegravir and Rilpivirine?
- If you have an allergy to dolutegravir and rilpivirine or any part of dolutegravir and rilpivirine.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with dolutegravir and rilpivirine, like some other drugs used for HIV or certain drugs used for seizures, infection, or stomach or bowel problems. There are many drugs that must not be taken with this drug.
- If you are taking St. John's wort. Do not take St. John's wort with dolutegravir and rilpivirine. This medicine may not work as well.
- If you are pregnant or may be pregnant. Do not take dolutegravir and rilpivirine if you are in the first trimester of pregnancy.
- If you are breast-feeding. Do not breast-feed while you take dolutegravir and rilpivirine.
This is not a list of all drugs or health problems that interact with dolutegravir and rilpivirine.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take dolutegravir and rilpivirine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Dolutegravir and Rilpivirine?
- Tell all of your health care providers that you take dolutegravir and rilpivirine. This includes your doctors, nurses, pharmacists, and dentists.
- If you have had hepatitis B or C, talk with your doctor.
- Some other drugs may need to be taken at some other time than dolutegravir and rilpivirine. If you take other drugs, check with your doctor or pharmacist to see if you need to take them at some other time than dolutegravir and rilpivirine.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine is not a cure for HIV. Stay under the care of your doctor.
- This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting dolutegravir and rilpivirine. Talk with your doctor.
- Use birth control that you can trust to prevent pregnancy while taking dolutegravir and rilpivirine.
- If you are pregnant or you get pregnant while taking dolutegravir and rilpivirine, call your doctor right away.
How is this medicine (Dolutegravir and Rilpivirine) best taken?
Use dolutegravir and rilpivirine as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with a meal.
- Do not use a protein drink in place of a meal.
- Keep taking dolutegravir and rilpivirine as you have been told by your doctor or other health care provider, even if you feel well.
- It is important that you do not miss or skip a dose of dolutegravir and rilpivirine during treatment.
- If you take products that have iron, aluminum, calcium, or magnesium in them (like some antacids or vitamins), you may need to take them at some other time than dolutegravir and rilpivirine. Talk with your doctor or pharmacist.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it, with a meal.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- If you are not sure what to do if you miss a dose, call your doctor.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
- Muscle or joint pain.
- Shortness of breath.
- Feeling very tired or weak.
- Changes in your immune system can happen when you start taking drugs to treat HIV. If you have an infection that you did not know you had, it may show up when you take dolutegravir and rilpivirine. Tell your doctor right away if you have any new signs after you start dolutegravir and rilpivirine, even after taking it for several months. This includes signs of infection like fever, sore throat, weakness, cough, or shortness of breath.
- Very bad skin and allergic reactions have happened with dolutegravir and rilpivirine. Skin reactions have happened along with fever or problems in body organs like the liver. Call your doctor right away if you have red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; sores in your mouth, throat, nose, or eyes; trouble swallowing; or signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
What are some other side effects of Dolutegravir and Rilpivirine?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Dolutegravir and Rilpivirine?
- Store at room temperature.
- Store in the original container. Do not take out the antimoisture cube or packet.
- Keep lid tightly closed.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about dolutegravir and rilpivirine, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about dolutegravir / rilpivirine
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 2 Reviews
- Drug class: antiviral combinations
- FDA Alerts (1)
Other brands: Juluca