Generic Name: daunorubicin liposomal (daw-noe-ROO-bi-sin)
Brand Name: DaunoXome
DaunoXome may cause heart problems, including heart failure, or bone marrow depression, making it hard to fight off infection. Notify your doctor immediately if you develop chest pain, an irregular heartbeat, trouble breathing, swelling of the hands or feet, easy bruising or bleeding, or signs of infection, such as fever, unusual fatigue, or persistent sore throat. Tell your doctor if you have liver problems or heart problems, or have had chest x-rays before starting treatment with DaunoXome. You may require smaller doses of DaunoXome or different treatment. DaunoXome can cause a reaction including back pain, flushing, and chest tightness. Notify your doctor immediately if you experience any of these symptoms.
DaunoXome is used for:
Treating advanced AIDS-related Kaposi sarcoma. It may also be used for other conditions as determined by your doctor.
DaunoXome is a cytotoxic agent. It works by preventing the cancer cell from reproducing, which results in death of the cancer cell.
Do NOT use DaunoXome if:
- you are allergic to any ingredient in DaunoXome
Contact your doctor or health care provider right away if any of these apply to you.
Before using DaunoXome:
Some medical conditions may interact with DaunoXome. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have bone marrow depression, heart disease, gout, or liver or kidney problems, or if you have taken DaunoXome before
Some MEDICINES MAY INTERACT with DaunoXome. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Certain medicines that act upon the liver (eg, methotrexate) or cyclosporine because the actions and side effects of DaunoXome may be increased
- Trastuzumab because the risk of heart problems may be increased
- Hydantoins (eg, phenytoin) because the effectiveness may be decreased and the risk of seizures may be increased by DaunoXome
This may not be a complete list of all interactions that may occur. Ask your health care provider if DaunoXome may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use DaunoXome:
Use DaunoXome as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- DaunoXome is usually administered as an injection at your doctor's office, hospital, or clinic.
- If DaunoXome contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
- If you miss a dose of DaunoXome, contact your doctor as soon as possible.
Ask your health care provider any questions you may have about how to use DaunoXome.
Important safety information:
- DaunoXome may cause drowsiness, dizziness, or tiredness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to DaunoXome. Using DaunoXome alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
- If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects.
- If you get DaunoXome on your skin, wash thoroughly with soap and water.
- DaunoXome may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.
- DaunoXome may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
- DaunoXome causes the urine to turn red. This is harmless and not a cause for concern.
- Check with your doctor before having vaccinations while you are using DaunoXome.
- LAB TESTS, including blood cell counts and heart and liver function tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
- Use DaunoXome with caution in CHILDREN because they may be more sensitive to its effects, such as heart problems.
- PREGNANCY and BREAST-FEEDING: DaunoXome may cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using DaunoXome during pregnancy. It is unknown if DaunoXome is excreted in breast milk. Do not breast-feed while taking DaunoXome.
Possible side effects of DaunoXome:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; hair loss; loss of appetite; mouth pain; nausea; sore throat; stomach pain; tiredness; weakness.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back pain; black, tarry stools; blood in the stools; chest pain; chills; cough or sore throat; excessive bleeding; fever; flushing; irregular heartbeat; pain, redness, or swelling at the injection site; shortness of breath; sores on the mouth or lips; unusual bruising or bleeding.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include nausea; tiredness; vomiting.Proper storage of DaunoXome:
DaunoXome is usually handled and stored by a health care provider. If you are using DaunoXome at home, store DaunoXome as directed by your pharmacist or health care provider. Keep DaunoXome out of the reach of children and away from pets.
- If you have any questions about DaunoXome, please talk with your doctor, pharmacist, or other health care provider.
- DaunoXome is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take DaunoXome or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about DaunoXome. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to DaunoXome. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using DaunoXome.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about DaunoXome (daunorubicin liposomal)
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- Drug class: antibiotics/antineoplastics