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Belladonna alkaloids/ methenamine/ methylene blue/ phenyl salicylate

Generic Name: belladonna alkaloids/methenamine/methylene blue/phenyl salicylate (bell-a-DON-a/meth-EN-a-meen/METH-i-leen/FEN-ill sa-LI-si-late)
Brand Name: Examples include Urised and Usept

Belladonna alkaloids/ methenamine/ methylene blue/ phenyl salicylate is used for:

Treating painful and irritating symptoms of the urinary tract due to urinary tract infections or diagnostic procedures.

Belladonna alkaloids/methenamine/methylene blue/phenyl salicylate is a urinary antiseptic, analgesic, and anticholinergic combination. It works by helping to kill bacteria in the urine, decreasing pain and inflammation, and reducing muscle spasms in the urinary tract. These actions work together to help relieve discomfort while urinating.

Do NOT use belladonna alkaloids/ methenamine/ methylene blue/ phenyl salicylate if:

  • you are allergic to any ingredient in belladonna alkaloids/methenamine/methylene blue/phenyl salicylate
  • you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to aspirin, other salicylate medicines, or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)
  • you have angle-closure glaucoma, problems with your esophagus, bowel motility problems, a blockage of your bladder or bowel, severe intestinal problems (eg, ulcerative colitis), severe bleeding, flu or chickenpox, myasthenia gravis, severe kidney problems, or you are severely dehydrated
  • you are taking a sulfonamide (eg, sulfamethizole)

Contact your doctor or health care provider right away if any of these apply to you.

Before using belladonna alkaloids/ methenamine/ methylene blue/ phenyl salicylate:

Some medical conditions may interact with belladonna alkaloids/methenamine/methylene blue/phenyl salicylate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have constipation, diarrhea, an infection of the stomach or bowel, a hiatal hernia, or stomach ulcers
  • if you have nervous system problems, glucose-6-phosphate-dehydrogenase (G-6-PD) deficiency, gout, influenza, Kawasaki syndrome, rheumatic disease, open-angle glaucoma, risk factors for angle-closure glaucoma, kidney or liver problems, an enlarged prostate, bladder problems, or you are unable to urinate
  • if you have a history of stroke or brain blood vessel problems (eg, aneurysm), an irregular heartbeat, heart blood vessel problems, congestive heart failure, heart valve problems, or other heart problems
  • if you are on a low-salt diet

Some MEDICINES MAY INTERACT with belladonna alkaloids/methenamine/methylene blue/phenyl salicylate. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, benztropine) because the side effects of belladonna alkaloids/methenamine/methylene blue/phenyl salicylate may be increased
  • Ketoconazole because the effectiveness of belladonna alkaloids/methenamine/methylene blue/phenyl salicylate may be decreased
  • Monoamine oxidase (MAO) inhibitors or narcotic pain medicine (eg, codeine) because the risk of serious side effects may be increased
  • Medicine for myasthenia gravis (eg, ambenonium), phenothiazines (eg, chlorpromazine), sulfonamides (eg, sulfamethizole), thiazide diuretics (eg, hydrochlorothiazide), or urinary alkalinizers (eg, sodium bicarbonate) because effectiveness may be decreased by belladonna alkaloids/methenamine/methylene blue/phenyl salicylate

This may not be a complete list of all interactions that may occur. Ask your health care provider if belladonna alkaloids/methenamine/methylene blue/phenyl salicylate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use belladonna alkaloids/ methenamine/ methylene blue/ phenyl salicylate:

Use belladonna alkaloids/methenamine/methylene blue/phenyl salicylate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Belladonna alkaloids/methenamine/methylene blue/phenyl salicylate may be taken with or without food.
  • Do not take antacids or antidiarrheal medicines (eg, loperamide) within 1 hour before or after taking belladonna alkaloids/methenamine/methylene blue/phenyl salicylate.
  • Drink plenty of fluids while taking belladonna alkaloids/methenamine/methylene blue/phenyl salicylate.
  • If you miss a dose of belladonna alkaloids/methenamine/methylene blue/phenyl salicylate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use belladonna alkaloids/methenamine/methylene blue/phenyl salicylate.

Important safety information:

  • Belladonna alkaloids/methenamine/methylene blue/phenyl salicylate may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to belladonna alkaloids/methenamine/methylene blue/phenyl salicylate. Using belladonna alkaloids/methenamine/methylene blue/phenyl salicylate alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Do not take belladonna alkaloids/methenamine/methylene blue/phenyl salicylate more often or in larger amounts than prescribed by your health care provider.
  • Belladonna alkaloids/methenamine/methylene blue/phenyl salicylate may discolor the urine or feces a blue-green color. This is normal and not a cause for concern.
  • Belladonna alkaloids/methenamine/methylene blue/phenyl salicylate contains an aspirin-like medicine, which has been linked to Reye syndrome. Do not give belladonna alkaloids/methenamine/methylene blue/phenyl salicylate to children or teenagers during or after chickenpox, flu, or other viral infections without checking with your doctor or pharmacist.
  • Use belladonna alkaloids/methenamine/methylene blue/phenyl salicylate with caution in the ELDERLY because they may be more sensitive to its effects, especially excitement, agitation, drowsiness, and confusion.
  • Belladonna alkaloids/methenamine/methylene blue/phenyl salicylate is not recommended for use in CHILDREN younger than 6 years of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is unknown if belladonna alkaloids/methenamine/methylene blue/phenyl salicylate can cause harm to the fetus. If you become pregnant while taking belladonna alkaloids/methenamine/methylene blue/phenyl salicylate, discuss with your doctor the benefits and risks of using belladonna alkaloids/methenamine/methylene blue/phenyl salicylate during pregnancy. Belladonna alkaloids/methenamine/methylene blue/phenyl salicylate is excreted in breast milk. If you are or will be breast-feeding while you are using belladonna alkaloids/methenamine/methylene blue/phenyl salicylate, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of belladonna alkaloids/ methenamine/ methylene blue/ phenyl salicylate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry mouth; flushing; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; difficulty urinating; dizziness; fast or irregular heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of belladonna alkaloids/methenamine/methylene blue/phenyl salicylate:

Store belladonna alkaloids/methenamine/methylene blue/phenyl salicylate at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep belladonna alkaloids/methenamine/methylene blue/phenyl salicylate out of the reach of children and away from pets.

General information:

  • If you have any questions about belladonna alkaloids/methenamine/methylene blue/phenyl salicylate, please talk with your doctor, pharmacist, or other health care provider.
  • Belladonna alkaloids/methenamine/methylene blue/phenyl salicylate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about belladonna alkaloids/methenamine/methylene blue/phenyl salicylate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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