Atazanavir and Cobicistat
Generic Name: Atazanavir and Cobicistat (at a za NA veer & koe BIK i stat)
Brand Name: Evotaz
Uses of Atazanavir and Cobicistat:
- It is used to treat HIV infection.
What do I need to tell my doctor BEFORE I take Atazanavir and Cobicistat?
- If you have an allergy to atazanavir and cobicistat or any part of atazanavir and cobicistat.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you are on dialysis, talk with your doctor.
- If you have liver disease.
- If you are taking another drug that has the same drug in it.
- If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with atazanavir and cobicistat, like certain drugs that are used for high cholesterol, migraines, or mood problems. There are many drugs that must not be taken with atazanavir and cobicistat.
- If you are taking St. John's wort. Do not take St. John's wort with atazanavir and cobicistat. This medicine may not work as well.
- If you are taking sildenafil to treat pulmonary arterial hypertension (PAH).
- If you have kidney or liver disease and are taking colchicine.
- If you are also taking tenofovir and you have kidney problems or take a drug that may harm the kidneys.
- If you are breast-feeding. Do not breast-feed while you take atazanavir and cobicistat.
This is not a list of all drugs or health problems that interact with atazanavir and cobicistat.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take atazanavir and cobicistat with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Atazanavir and Cobicistat?
- Tell all of your health care providers that you take atazanavir and cobicistat. This includes your doctors, nurses, pharmacists, and dentists.
- This medicine interacts with many other drugs. The chance of atazanavir and cobicistat's side effects may be raised or how well atazanavir and cobicistat works may be lowered. The chance of the other drugs' side effects may also be raised. This may include very bad, life-threatening, or deadly side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take atazanavir and cobicistat with all of your other drugs (prescription or OTC, natural products, vitamins).
- If you have high blood sugar (diabetes), talk with your doctor. This medicine may raise blood sugar.
- Check your blood sugar as you have been told by your doctor.
- Some people with hemophilia have had times of more bleeding when taking drugs like this one. If you have hemophilia, talk with your doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine is not a cure for HIV. Stay under the care of your doctor.
- This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors. Talk with your doctor.
- Very bad kidney problems like kidney failure have happened in people taking cobicistat with tenofovir. Talk with your doctor.
- Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking atazanavir and cobicistat.
- Do not give atazanavir and cobicistat to a child younger than 3 months of age.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using atazanavir and cobicistat while you are pregnant.
How is this medicine (Atazanavir and Cobicistat) best taken?
Use atazanavir and cobicistat as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take atazanavir and cobicistat with food.
- Do not take antacids within 2 hours before or 2 hours after taking atazanavir and cobicistat.
- If you are also taking didanosine, take it at least 1 hour before or 2 hours after atazanavir and cobicistat.
- If you take cimetidine, dexlansoprazole, esomeprazole, famotidine, lansoprazole, nizatidine, omeprazole, pantoprazole, rabeprazole, or ranitidine, ask your doctor or pharmacist how to take it with atazanavir and cobicistat.
- It is important that you do not miss or skip a dose of atazanavir and cobicistat during treatment.
- Keep taking atazanavir and cobicistat as you have been told by your doctor or other health care provider, even if you feel well.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- If you are not sure what to do if you miss a dose, call your doctor.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Signs of gallstones like sudden pain in the upper right belly area, right shoulder area, or between the shoulder blades; yellow skin or eyes; or fever with chills.
- Dizziness or passing out.
- Muscle or joint pain.
- Pain when passing urine.
- Back pain, belly pain, or blood in the urine. May be signs of a kidney stone.
- A heartbeat that does not feel normal.
- Very upset stomach or throwing up.
- Change in body fat.
- Yellow skin or eyes.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- This medicine may help the immune system work. If you have an infection that you did not know you had, it may show up when you take atazanavir and cobicistat. Tell your doctor right away if you notice any signs of infection like fever, sore throat, weakness, cough, or shortness of breath after you start atazanavir and cobicistat.
What are some other side effects of Atazanavir and Cobicistat?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Loose stools (diarrhea).
- Upset stomach.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Atazanavir and Cobicistat?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer Information Use and Disclaimer
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about atazanavir and cobicistat, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Disclaimer: This information should not be used to decide whether or not to take atazanavir and cobicistat or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about atazanavir and cobicistat. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to atazanavir and cobicistat. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using atazanavir and cobicistat.
Review Date: March 7, 2018
More about atazanavir/cobicistat
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
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- Drug class: antiviral combinations
Other brands: Evotaz