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Generic Name: atazanavir and cobicistat (A t ZAN a vir and koe BIK i stat)
Brand Names: Evotaz

Medically reviewed by Last updated on Nov 27, 2019.

What is Evotaz?

Evotaz contains a combination of atazanavir and cobicistat. Aatazanavir is a protease inhibitor antiviral medication that prevents human immunodeficiency virus (HIV) from multiplying in your body. Cobicistat reduces the action of enzymes in your liver that break down certain antiviral medicines. This allows the antiviral medicines to be used more safely and effectively at lower doses.

Evotaz is given together with other antiviral medicines to treat human immunodeficiency virus (HIV) in adults. HIV is the virus that can cause acquired immunodeficiency syndrome (AIDS). This medicine is not a cure for HIV or AIDS.

Evotaz may also be used for purposes not listed in this medication guide.

Important information

Serious drug interactions can occur when certain medicines are used together with Evotaz. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.

Before taking this medicine

You should not take Evotaz if you are allergic to atazanavir and cobicistat.

Some medicines can interact with atazanavir and cobicistat and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • alfuzosin;

  • cisapride;

  • colchicine;

  • dronedarone;

  • elbasvir/grazoprevir;

  • indinavir;

  • irinotecan;

  • lovastatin, simvastatin;

  • lurasidone;

  • oral midazolam, triazolam;

  • nevirapine;

  • pimozide;

  • ranolazine;

  • rifampin;

  • sildenafil (Revatio, for treating pulmonary arterial hypertension);

  • St. John's wort;

  • ergot medicine - dihydroergotamine, ergotamine, ergonovine, methylergonovine; or

  • seizure medicine - carbamazepine, phenobarbital, phenytoin.

To make sure Evotaz is safe for you, tell your doctor if you have:

  • heart disease;

  • liver disease (especially hepatitis B or C);

  • a bleeding or blood clotting disorder such as hemophilia;

  • diabetes; or

  • kidney disease (or if you are on dialysis).

Evotaz is not expected to harm an unborn baby. However, atazanavir may cause a serious condition called lactic acidosis in the mother if taken with certain other medicines. Tell your doctor if you are pregnant or plan to become pregnant. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

Use a barrier form of birth control (condom or diaphragm with spermicide). Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Evotaz is not approved for use by anyone younger than 18 years old.

How should I take Evotaz?

Take Evotaz exactly as prescribed by your doctor. This medicine is not a complete treatment and must be used in combination with other antiviral medicines your doctor has prescribed. However, there are certain antiviral medicines that should not be taken in combination with Evotaz. Follow your doctor's medication and dosing instructions very carefully.

Follow all directions on your prescription label. Do not take Evotaz in larger or smaller amounts or for longer than recommended.

Take Evotaz with food.

While using Evotaz, your blood may need to be tested often. Your kidney and liver function may also need to be tested.

If you take Evotaz with a medicine to reduce stomach acid, follow the recommendations below:

  • If you take an antacid: Take the antacid at least 2 hours before or 2 hours after you take Evotaz.

  • If you take a medicine such as cimetidine, ranitidine, Tagamet, Axid, Zantac, Pepcid, and others: You may either take the stomach medicine at the same time you take Evotaz; or wait at least 10 hours after taking the stomach medicine to take your Evotaz doses.

  • If you take a proton pump inhibitor such as omeprazole, esomeprazole, Nexium, Prevacid, Prilosec, Protonix: Wait at least 12 hours after taking the stomach medicine to take your Evotaz doses.

Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Store Evotaz in the original container at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use.

Evotaz dosing information

Usual Adult Dose for HIV Infection:

1 tablet orally once a day with food

-For therapy-naive and therapy-experienced patients
-The number of baseline primary protease inhibitor resistance substitutions should guide use in therapy-experienced patients.

Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

What happens if I miss a dose?

Take the missed dose as soon as you remember. If you are more than 12 hours late, skip the missed dose. Then take your combination of medicines (Evotaz with atazanavir, or Evotaz with darunavir) at your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Evotaz?

If you also take enteric-coated didanosine (Videx EC), take it 1 hour before or 2 hours after you take Evotaz.

Taking this medication will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Evotaz side effects

Get emergency medical help if you have any signs of an allergic reaction to Evotaz: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

This medicine may increase your risk of certain infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment with atazanavir and cobicistat. Tell your doctor if you have:

  • signs of a new infection - fever, night sweats, swollen glands, mouth sores, diarrhea, stomach pain, weight loss;

  • chest pain (especially when you breathe), dry cough, wheezing, feeling short of breath;

  • cold sores, sores on your genital or anal area;

  • rapid heart rate, feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;

  • trouble speaking or swallowing, severe lower back pain, loss of bladder or bowel control; or

  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.

Call your doctor at once if you have:

  • severe dizziness, fainting, irregular heartbeats;

  • liver problems - upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss;

  • signs of a kidney stone - pain in your side or lower back, painful or difficult urination, blood in your urine;

  • signs of inflammation in your body - swollen glands, flu symptoms, easy bruising or bleeding, severe tingling or numbness, muscle weakness, upper stomach pain, jaundice (yellowing of the skin or eyes), chest pain, new or worsening cough with fever, trouble breathing; or

  • severe skin reaction - fever, sore throat, swelling in your face or tongue, burning or redness in your eyes, skin pain, warmth or redness under your skin, red or purple skin rash that spreads and causes blistering and peeling.

You may need to stop taking this medicine permanently if you have a severe skin reaction.

Common Evotaz side effects may include:

  • rash;

  • nausea; or

  • jaundice.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect atazanavir and cobicistat?

Many drugs can interact with atazanavir and cobicistat, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with atazanavir and cobicistat. Give a list of all your medicines to any healthcare provider who treats you.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Evotaz only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.