Atazanavir / Cobicistat Dosage
Medically reviewed on July 12, 2017.
Applies to the following strengths: 300 mg-150 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for HIV Infection
1 tablet orally once a day with food
-For therapy-naive and therapy-experienced patients
-The number of baseline primary protease inhibitor resistance substitutions should guide use in therapy-experienced patients.
Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection
Renal Dose Adjustments
No adjustment recommended.
When used with tenofovir disoproxil fumarate (DF):
-Estimated CrCl less than 70 mL/min: Not recommended.
-In combination with concomitant or recent use of nephrotoxic agent: Not recommended.
Liver Dose Adjustments
Any degree of liver dysfunction: Not recommended.
-Clinically significant hypersensitivity (e.g., Stevens-Johnson syndrome, erythema multiforme, toxic skin eruptions) to either active component or to any of the ingredients
-Coadministration with drugs highly dependent on CYP450 3A or UGT1A1 for clearance and for which elevated plasma levels are associated with serious and/or life-threatening events
-Coadministration with strong CYP450 3A inducers that may result in lower exposure and loss of efficacy of this drug
-Coadministration with alfuzosin, ranolazine, dronedarone, carbamazepine, phenobarbital, phenytoin, rifampin, irinotecan, lurasidone, oral midazolam, triazolam, dihydroergotamine, ergotamine, methylergonovine, cisapride, elbasvir-grazoprevir, glecaprevir-pibrentasvir, St. John's wort, lovastatin, simvastatin, pimozide, drospirenone-ethinyl estradiol, nevirapine, indinavir, sildenafil (for treatment of pulmonary arterial hypertension)
-Coadministration with colchicine in patients with renal and/or liver dysfunction
Safety and efficacy have not been established in patients 3 months to less than 18 years; this drug is not recommended for use in patients younger than 3 months (due to risk of kernicterus).
Consult WARNINGS section for additional precautions.
HIV-1 therapy-experienced patients with ESRD managed with hemodialysis: Not recommended.
-The components of this drug are highly protein-bound; significant removal via hemodialysis or peritoneal dialysis is not likely.
-Perform renal laboratory testing (including serum creatinine, estimated CrCl, and urinalysis with microscopic examination) in all patients before starting this drug and continue during therapy.
-When used with tenofovir DF, assess estimated CrCl, urine glucose, and urine protein at baseline then monitor routinely during therapy.
-Perform hepatic laboratory testing in patients with underlying liver disease before starting this drug and continue during therapy.
-Use in combination with other antiretroviral agents.
-Administer with food; maintain adequate hydration.
-Dose separation may be necessary with H2-receptor antagonists or proton-pump inhibitors; consult the manufacturer product information for further guidance.
-Consult the manufacturer product information regarding missed doses.
-Store at 25C (77F); excursions permitted to 15C to 30C (59F to 86F).
-Keep bottle tightly closed.
-Each fixed-dose combination tablet contains atazanavir 300 mg and cobicistat 150 mg.
-Cobicistat decreases estimated CrCl; it inhibits tubular secretion of creatinine without affecting actual renal glomerular function.
-Cardiovascular: ECG in patients with preexisting conduction disorders
-Hepatic: Hepatic laboratory testing in patients with underlying liver disease (before starting and during therapy); hepatic laboratory tests in patients with HBV, HCV, or marked transaminase elevations at baseline (before starting and during therapy); for severe hyperbilirubinemia in all infants (first few days of life)
-Metabolic: Serum phosphorus in patients at risk of renal dysfunction (when used with tenofovir DF)
-Renal: Renal laboratory testing, including serum creatinine, estimated CrCl, and urinalysis with microscopic examination, in all patients (before starting and during therapy); for renal safety (if serum creatinine increases more than 0.4 mg/dL from baseline); estimated CrCl, urine glucose, and urine protein (at baseline and routinely during therapy [when used with tenofovir DF])
-Read the US FDA-approved patient labeling (Patient Information).
-This drug may cause changes in ECG (e.g., PR prolongation); consult healthcare provider if dizziness/lightheadedness occurs.
-Seek medical evaluation at once if signs/symptoms of severe skin reactions or hypersensitivity reactions develop (including, but not limited to, severe rash or rash with fever, general malaise, muscle/joint aches, blisters, oral lesions, conjunctivitis, facial edema).
-Drink plenty of fluids while using this drug.
-Notify healthcare provider at once of any symptoms of infection.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about atazanavir/cobicistat
- Atazanavir/cobicistat Side Effects
- During Pregnancy
- Drug Interactions
- En Español
- Drug class: antiviral combinations
Other brands: Evotaz