Skip to Content

The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.


Generic Name: tuberculin purified protein derivative (ppd) (too-BER-kyoo-lin)
Brand Name: Examples include Aplisol and Tubersol

Aplisol is used for:

Detecting tuberculosis (TB) infection.

Aplisol is a diagnostic agent. It works by causing a mild, delayed allergic reaction in patients infected with TB or who have had a past infection, which allows for detection of TB.

Do NOT use Aplisol if:

  • you are allergic to any ingredient in Aplisol or you have previously had a severe reaction (eg, sores, skin wasting) to Aplisol

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aplisol:

Some medical conditions may interact with Aplisol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a viral infection (eg, HIV, chickenpox), known TB infection or a previous positive tuberculin skin test, another bacterial infection (eg, strep throat), cancer, or severe protein deficiency
  • if you have recently been given a live vaccine (eg, measles, flu)

Some MEDICINES MAY INTERACT with Aplisol. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Corticosteroids (eg, prednisone), immunosuppressives (eg, certain cancer medicines, cyclosporine), or live vaccines (eg, measles) because the effectiveness of Aplisol may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aplisol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aplisol:

Use Aplisol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Aplisol is usually administered as an injection at your doctor's office, hospital, or clinic.
  • If Aplisol contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • The result is read 48 to 72 hours after administration. Be sure to keep your appointment to have the result read. It may be necessary to have a follow-up test done, depending on your potential to come in contact with TB.
  • If you miss a dose of Aplisol, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Aplisol.

Important safety information:

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Aplisol during pregnancy. If you are or will be breast-feeding while you are using Aplisol, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Aplisol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Pain, itching, or redness at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blisters; open sores.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Aplisol:

Aplisol is usually handled and stored by a health care provider. If you are using Aplisol at home, store Aplisol as directed by your pharmacist or health care provider. Keep Aplisol out of the reach of children and away from pets.

General information:

  • If you have any questions about Aplisol, please talk with your doctor, pharmacist, or other health care provider.
  • Aplisol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Aplisol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Aplisol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Aplisol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Aplisol.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.