Switching from Cymbalta to Pristiq?

Ask your doctor about tapering off pristiq. It's made with a matrix for slow release and it can't be split in half. Just know what your getting into. Took pristiq for 18 years. Mostly 25mg.

I have taken both and cymbalta for me was horrible, it progressed slowly to a much worsening depression and weight gain. I have also taken Pristiq, that was much more tolerable and less side effects. However, I can say in my experience when just switching to a new SNRI my docs have just decreased the dose of one then started the new or all together just change. I have found personally that the SNRI’s are not for me. Have had side effects that weren’t great and didn’t help much with the true issue. I went off everything for almost a year and recently needed anxiety relief so started back on lexapro, I much prefer the SSRI’s the others are in my (my own -non medical opinion) too much.
I would do what your MD recommends as to how to make that change. Just be sure to always read those warnings (black box warnings etc). It can be a long road and I pray you are finding relief soon.