I'm nearly 4 week's taking sertraline. Started on December the 9th. I felt a few small positive changes, the first 2 week's. Then u got my menstruation on December the 30th. And thing's have gotten worse! I'm extremely depressed, unable too get out of bed or function. Constant suicidal thoughts though I was getting them before starting sertraline. Only feel worse though! I'm constantly crying and really unsure what too do!? I started on 50mg, past 4 day's increased to 100mg. I honestly don't want to b here anymore im sick of fighting this depression it is pure hell! Should I carry on taking them? Surely 4 weeks i shouldn't be this depressed? I took venlafaxine 15 years before, they literally saved my life twice! Then stopped working after so long. I feel right now there's no hope! Can't see a way forward. I read after 2 weeks depression should b less with these sertraline. Sorry long post im desperate for some advice? With people who have or are on sertraline. I was given them for pmdd and major depression.