Has anyone ever taken Seroquel and trazodone together? Can take 50mg. of each at night and 50mg more in afternoon for severe anxiety and also for depression, per my prescription. I’m a little afraid to take both. But have to have some sleep. Usually, up most of night. Have been taking 50 mg. of trazodone for a couple of years, and have withdrawals when I try to get off. That’s why I am prescribed both. My usual medication is maprotiline, but Mylan stopped making it. Ordering it from Canada, but will take 2-4 weeks to get here. Was hoping the trazodone and Seroquel would hold me over until it gets here. Can anyone help me? Thank you.