I have a blockage and plaque present in my coronary artery will Plavix dissolve that clot? After having a Heart Catheterization Procedure With Pci. After the procedure the doctor and his team determined a stint was not required as the doctor felt the blockage was small enough to be treated with medication! If plavix does dissolve clots and plaque in the blood. Lets say its blocking 50% of the artery how long will it take to dissolve the clock!