I was taking Seroquel last year for about 6 weeks for sleep. It worked really well for me, but I ended up gaining weight so I discontinued it. I am still having problems with sleep, so my dr prescribed Saphris, which I don't really like so far. I was thinking of going back to Seroquel. Do most people that are taking Seroquel gain weight? I was eating very healthy at the time and still gained about 10-15 pounds. My dr told me that it changes your metabolism, which leads to the weight gain. Is there any way to combat this?
Hi, i also take Seroquel (200mg XR) and i have put on a lot of weight unfortunately. I think when it is used for sleep, you shouldn't notice such a big difference as the dose is much lower, so you might be in a different position to me. The only way to 'combat' this is to lower you daily calorie intake and exercise, to increase your metabolism
Hi, Cathy! No, in clinical trials 6% of patients reported weight gain as opposed to 3% who took a placebo and also reported weight gain. Now, these results involve clinically significant weight gain which is an increase of over 10lbs so some gain might be expected, but it would be purely cosmetic rather than physically dangerous.
Best wishes and good luck. BTW, I gained no weight on Seroquel. Wildcat
Though I put in my 2 cents:
Logistic regression analysis has shown a positive dose response for dyspepsia and abdominal pain.
Very common (10% or more): Dry mouth (up to 44%),
Common (1% to 10%): Constipation, dyspepsia, vomiting, abdominal pain, gastroenteritis, gastroesophageal reflux disease, dysphagia
Uncommon (0.1% to 1%): Increased salivation, gingivitis, flatulence, hemorrhoids, stomatitis, mouth ulceration, tongue edema
Rare (0.01% to 0.1%): Glossitis, hematemesis, intestinal obstruction, melena
Frequency not reported: Pancreatitis
Weight gain: Logistic regression analysis has shown a positive dose response for weight gain. Five to 10% of adult patients experienced a weight gain of 7% or greater (vs. up to 5% in placebo). Among children and adolescents, a weight gain of 7% or greater occurred in 7% to 21% of patients receiving this drug compared with up to 7% in placebo patients. Mean change in body weight was 1.7 to 2 kg in 3 to 6 week trials and 4.4 kg in 26 week trials. These results were not adjusted for normal growth.[Ref]
Very common (10% or more): Hyperglycemia, increases in serum triglycerides, hyperlipidemia,
Common (1% to 10%): Weight gain, increased appetite, thirst
Uncommon (0.1% to 1%): Weight loss, alkaline phosphatase increased, hyperglycemia, hypoglycemia
Rare (0.01% to 0.1%): Glycosuria, gout, hypokalemia, water intoxication, metabolic syndrome
Postmarketing reports: Hyponatremia
Hi Cathypw79, I've been taking .25mg of seroquel for sleep for at least 6 months. I didn't have a problem with weight gain. You mentioned you eat healthy. I noticed when it finally starts to work, I get the munchies and a bunch of times I've eaten and then fell asleep right after. Surprisingly, it didn't make me gain weight. A lot of those type of meds can make you gain weight. I would think it depends on the person and if other meds are being taken. If your dr says it changes your metabolism, making it slower, maybe there are things you can do to keep your metabolism from going too slow instead of taking a different med that might have even worse side effects than weight gain. Sorry that wasn't much of a help.
Just an update. I have been taking Seroquel 25mg for sleep for almost a month now. So far so good when it comes to no weight gain, which is great! My dr recommended going up to 50mg to see if that would help with mood and anxiety as well. Again, I'm scared that I will gain weight, especially with doubling the dose.
- Seroquel Information for Consumers
- Seroquel Information for Healthcare Professionals (includes dosage details)
- Side Effects of Seroquel (detailed)
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