Since on nexium I have been experiencing pain and soreness in my forearm, shoulder and leg all on?

In my opinion, yes, the Nexium can cause these problems as I took Omeprazole which is also a PPI just as the Nexium is. I had the gout in my toe and all kinds of arthritic type pains and took a tylenol every day until I realized they were giving me lower back pain. Nexium also interferes with B12 so you should be asking for blood tests periodically. If I were in your place, and this is only my opinion, I would never ever start a PPI which Nexium is, I would go with Zantac which dilutes the acid, not stopping the production of acid which is so necessary to our system. I had so many side affects such as sinus infections, urinary tract infections, breathing problems and pains in my hands and feet which have all gone away since I stopped the PPI medication. If the Androgel was helping and the side effects were not bad, why stop that and start a PPI? I became so addicted to the Omeprazole (Prilosec) that it took me months and months to be able to get off of them completely. My GI doctor wanted me to have a fundiplication procedure but I decided to slowly wean myself from the PPI... it is not easy but I am very careful to eat properly and slowly and very little food each time but more times a day... good luck to you!
AquariusAnneCA