I have seen a lot of post on the internet about mirtazapine and weight gain. Saying that the medication it self puts wright on you. How can a tablet do that? Surley it is what you eat? I can understand that the med can increase your appetite, so if you eat healthly then you shouldnt put weight on? Any comments would be welcomed Jools
Mirtazapine and weight gain?
Question posted by jools 2013 on 7 May 2013
Last updated on 19 October 2022 (7 weeks ago) by Cyberia08
I've been on mirtazapine 30mg for years now. When I was started on the drug, I was told that it might make me gain some weight and it did. I was 155 lbs at the start and have leveled off at 220 lbs. In a matter of months I went from a 34 inch waste to a 40 inch belly. I have tried countless drugs to tamp down the nightmares I was having due to PTSD but nothing worked until mirtazapine. When I started to rapidly gain weight my doctor adjusted the dosage but lower doses just let the nightmares back in. For me, the drug has been a savior. Nothing, has even come close to allowing me to drift off to sleep and awake feeling like I had a good nights sleep, and I've tried plenty. I do have an increased appetite, but like I said, my weight have leveled off. I continue to eat healthy, excercise and control what I put in my body. With all drugs you have to weigh the benefits versus the side effects.
If you take mirtazapine, most likely, you are going to gain weight; at least at the 30mg dosage. If you are adverse to the weight, try other drugs first and then circle back if nothing else seems to do the trick. I might add, mirtazapine alone did not solve my issues. It is a combination of several drugs and mirtazapine was the missing key ingredient. If you start gaining weight, don't be afraid to talk to your doctor about lower dosages and/or alternative treatments.
These are a few of the metabolic changes that antidepressants can cause:
Common (1% to 10% of users): Decreased appetite, increased appetite, weight increased
Uncommon (0.1% to 1% of users): Abnormal glucose tolerance, anorexia, carbohydrate craving, diabetes mellitus, gout, hypercholesterolemia, hyperglycemia, hyperlipidemia, thirst, weight decreased
Frequency not reported: Hyponatremia
Postmarketing reports: Hypoglycemia, hypokalemia
I put on about 10 pounds in 9 months.
I have been on Mirtazapine 7.5 for 9 months. It was prescribed for sleep. I have gained about 7 lbs, maybe a little more, however I was 15 lbs overweight when I started taking it. I'm not a doctor or pharmacist but I don't think the pill makes you gain weight except that it increases your appetite. I crave carbs like crazy now. I've tried to cut back on carbs unsuccessfully. It's like an addition. The reason I continue to take it is because overall I feel better than I have for a really long time. I am also taking Wellbutrin 300mg once a day and have been for years but adding this small dose of Mirt along with Wellbutrin has given me my energy and motivation back. It's seems a small price to pay for emotional well being. Some has suggested that increasing the dose of Mirt will cause less weight gain but you may lose sleep benefits.
I was prescribed the 15 mg dose in September of 2019 to help with sleep and anxiety, and it did help but within just a couple months I started putting weight on. I'm 6'5" with an athletic build and weighed 220 when I started the medication and was even a little thin but by September of 2021 (taking the 30 mg dose), I was 265 and felt miserable about myself. The negatives started outweighing the positives so I backed my dosage down to 7.5 mg and take it only when I feel I need it. I'm about 6 weeks in on healthy eating and daily exercise and I'm down to 235 and feel so much better. But, I agree with those that say it's not the pill itself that puts the weight on, it's the food choices you make on the medication influenced by the cravings this drug causes, like late night carb binging. I knew I was making terrible food choices all along but had never struggled with weight but it finally caught up with me.
I think there are much better alternatives out there with far fewer side effects, just my input but I would caution anyone who's not ready to diet and exercise to steer clear of mirtazapine.
I’m on 15mg Mirtazapine now, down from 30mg. I was having difficulty with some hot flashes. I lost weight due to severe anxiety so my GP felt this med would help me regain some weight. Not so as of yet. As much as I try I pretty much have leveled where I am. I am normally thin but through the years I did gain some weight…high normal for my size. I’m now on the low normal side and cannot seem to put on a pound. It could be because I eat a whole food plant based diet…or because I still feel anxiety during the day. I had some issue with vivid dreams for the first week but no longer. I’m hoping the anxiety will lesson. I really dislike taking meds for GAD but know I have to for life. I was successful with first two Clinical Depressions but used different meds at those times. Mirtazapine is a newer med and I have read good reviews from studies. I hope I don’t have to change and that it will continue to help. Right now I sleep about 8 hours a night, so very good for that.
Very common (10% or more of users): Increased appetite (up to 17%), weight gain (up to 12%)"
Unfortunately, most, if not all, psychotropic medications (and many other types of drugs) have the potential for causing weight changes in a small number of patients because they change your entire metabolism.
Diet and exercise are only part of the equation to prevent excessive weight gain. If weight gain on an antidepressant is clinically significant your doctor may have you try a different antidepressant... one that is considered more "weight neutral"... that may cause some weight gain OR weight loss.
Dont know how but it does regardless of what you eat. Many drugs make you gain weight . But this one makes me hungry all the time and I've put on 3 stone. Trying to eat healthy. The only one a.d. I had which didnt was Duloxetine. Best wishes
Mirtazapine induces weight by raising serum level triglycerides and a voracious appetite for carbohydrates. I gained 20 kg and and consequently on antihypertensives and cholesterol lowering drugs as a result of use of Mirtazapine. I wish I could say it was a success for me but it was a disaster. I have ceased taking this drug and am on a newer superior medication called vadoxan which works well for my insomnia.
From what I have read it is a combo of appetite and metabolism effects. I am on 30mg and I am not satisified unless I am constantly full. I have been gaining a pound a week and am wondering if it will ever stop. It works excellent for my depression but if I gain too much more I am going to discontinue but I have tried many others that don't work as well.
Well, it definitely puts weight on. As a usual 11 stone tall woman I shot up to 15 stone+. I’ve never been fat in my life but this does pile on weight. It’s renown for it. I guess, even the doctors don’t know why. It must stimulate something in the body (cortisol)? Not sure what it stimulates. I went from a 12 to a size 18. They say it’s because it causes a voracious appetite. I didn’t really have that problem. Within a week you can see some extra pounds on. It’s lethargic inducing too. It may not happen with everyone but it would with 90% of the population I reckon.
There is a bit more to it than an increase in appetite. I read in a few studies, they believed it slowed down metabolism, increased a hormone level, and also sent signals to your brain to make your body store fat. It is an antidepressant so it does effect your brain chemistry which in turn controls your body’s functions. It has been prescribed to people with anorexic who may be hospitalized and need to put on weight fat fast. It is also prescribed to people in the later stages of AIDS to help with weight as well. One man blogged he counted calories and exercise on the medicine. I think he only ate about 500 a day and excised everyday just to maintain on the medicine. I myself had a personal trainer 2 times a week and kickboxed twice a week at the time. I put on 12 pounds in 3 weeks. I gained 30 pounds 3 months on it. I was not eating more than normal. It took awhile to come off too but being off it a week I dropped about 5.
My trainer said he was worried how much I would have gained had I not been working out. Some people do not gain and that’s great the majority I found do. It’s a rough drug. To me my fitness is a big part of my health so it was not worth it for me. Also, it does something to your blood sugar levels. I know my doctor wanted me to get tested when I started.
I started taking Mirtazapine in October for BPD, and am already coming off it. I can't be sure if it helped my mood or not, but 30mg each night made me gain a stone in a month! I was a size 8 and now I just feel very self conscious. Haven't lost any weight yet but hopefully once it's out my system it'll disappear. I miss the good nights sleeps though!!
Yes, you are correct. If you eat healthy and within reason most likely you will not gain weight. HOWEVER, I have eaten healthy and within reason my entire life. I was probably even a little obsessed with staying slender. This medication gave me a voracious appetite!!! I wanted sweets all the time. I could not get enough!! In two years, I went from 140lbs to 220lbs (5'8"). That absolutely is not an exaggeration. It was as if I had no control. I got off of it 6 months ago and I've lost 30lbs. I don't really have the cravings for carbs and sugar anymore but now my metabolism is shot.
I know my experience is somewhat unusual because of how much weight I gained but it happened. I guess what I'm saying is, my self control was virtually non-existent on this medication.
Mirtazapine puts weight on. I’ve been on it 15 years. The first two weeks of onset I immediately started to look pregnant. It may not everyone but I’d say most folk WILL put weight on. I fasted for two weeks. My weight did not change. I think it upsets the metabolism/system. Eating more may contribute to weight gain, but that’s secondary. I went from a size 10/12 to an 18 at full dose. A small frame but I’m tall. It’s taken a long time to lose weight, it’s a slow process. I’ve weaned to a very low dose now 3mg’s. I’ve lost 10 kilos. My tummy is still quite big but I’m trusting in stopping this drug, I’ll return to my normal weight.
- Mirtazapine uses and safety info
- Mirtazapine information for Healthcare Professionals (includes dosage details)
- Side effects of Mirtazapine (detailed)
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