I have seen a lot of post on the internet about mirtazapine and weight gain. Saying that the medication it self puts wright on you. How can a tablet do that? Surley it is what you eat? I can understand that the med can increase your appetite, so if you eat healthly then you shouldnt put weight on? Any comments would be welcomed Jools
Gastrointestinal side effects including dry mouth (25%), increased appetite (17%), and constipation (13%) have been reported. Other reported gastrointestinal adverse effects have included diarrhea (9%), nausea (4%), vomiting, anorexia, cholecystitis, glossitis, and colitis. One case of subclinical pancreatitis has also been reported.
Metabolic side effects have been reported. Nonfasting triglyceride increases to greater than 20% above the normal upper limits have been reported in 15% of patients receiving mirtazapine in clinical trials. Weight gain has been reported in 12% of patients. Less frequently reported were peripheral edema (2%), thirst, and weight loss. In one small study, mirtazapine appeared to improve glucose tolerance by reducing cortisol secretion.
Hi, I was on mirtazapine for many years and kept a steady weight. It did increase my appetite but I agree with you and if you eat healthy you should maintain your weight and not put any one. Like anything though some people find it affects them differently but I was happy when on it.
Good Luck and don't be too concerned about it. Cheers Tony
I have been on Mirtazapine for over a month now. The first week and a half I did nothing but gain weight. I gained approximately 10 lbs. I am 5'2" and weighed 128. I now weigh 138. I put myself on a diet and rejoined the gym - to no avail. Not only did the weight come on suddenly and quickly, but it is all in my belly area. I look and feel pregnant! - I feel ridiculous, and I am definitely going to go off of this drug. It is just not for me. I feel that I am dealing with a combination of the weight gain and a difference in how fat is distributed throughout my body . What is difficult, is that I'm not 100 % sure it isn't my eating. This was during Thanksgiving & Christmas time. I DO know that I was at a steady weight for 5 years now and after a week or so on Mirtazapine I started gaining weight. However, I was also weaning off of Effexor.
- I'm doing a "what if Effexor caused me to lose weight" thing. So with this happening during the holidays, and while going off another drug, I'm not sure exactly the cause. I took my last Effexor over a week or so ago. Now it's just me, my diet and Mirtazapine. The extra 10 lbs is not doable for me and I am going to start weaning of Mirtazapine today. - I just cannot deal with the anxiety this weight increase is causing me. I just hope it IS the Mirtazapine and that I'm not making the wrong decision. I will update as to if I experience weight loss, etc. from coming off this drug. My belly weight even causes my back to hurt. It's just all in the belly. Gross! :) If, by surprise, I end up going into labor, I will post pics of the baby and try Mirtazapine again. :)
For the last two weeks I've been trolling the internet, worried about two side effects of mitrazipine-somnelence (sleepiness, grogginess, tiredness) and weight gain.
I was on Lexapro (20mg), Wellbutrin (300mg), Propranolol (80mg), and Seroquel (50mg).
Two days ago I stopped taking Seroquel and instead started taking Mirtazapine, 30mg. I was taking seroquel for insomnia, but I switched to mirtazapine strictly for its antideppressant effects. Furthermore, seroquel increased my appetite like a mo-fo. In the last 6 months I have jumped from 130lb to 160lb. I dont know if this was caused by seroquel;however, I know for a fact that I get extremely hungry after I take seroquel at night.
Seroquel caused no morning groginess, I got off of it because I dont want to be on too many medications, I dont want to gain any more weight, and, since mirtazapine is known to cause drowsiness, I dont think I will need it.
My first night taking mirtazapine was two nights ago. I took it at 11:00 O'clock. At 11:30 I fell asleep, I woke up at 5 P.M. the next day. Although I slept for 17 hrs, unlike seroquel, I did not get the munchies at any point during that night or the next day. There was noticable day-time drowsiness.
Last night was my second night of taking Mirtazapine 30mg. I took it at 11 O'Clock. I fell asleep at 11:30, I woke up at 9 A.M. feeling extremely refreshed.
It only took ONE DAY for tolerance to the sedation to build up. I was so fricken happy that this was the case. There are lots of people on internet forums claiming the drowsiness persisted, but my research into Histimine Receptors hinted that it wouldnt. Based on studies with doxylamine and diphenhydramine, Histamine recepters up and down regulate extremely quickly. And, assuming Mirtazipine's hypnotic effects are mediated strictly by these H1 pathways, my personal experience backs it up.
As for the hunger and weight gain... Mirtazapine (at least compared to Seroquel 50mg) does not make me hungry. On wiki I read that Mirtazapine can increase triglyceride levels... idk where that comes into play with the whole weightgain thing. Maybe mirtazapine causes the body to process fat more efficiently, maybe increased triglycerides are a side effects of the hunger it can bring about. I dont know;only time will tell.
I believe it is the increased appetite. I was very wary about this this anti depressant as I was worried i was going to pile the weight on.
When I first started taking mirtazapine I was eating rubbish. I piled on a stone within a month. I stopped taking it instantly I felt rubbish still because I gained weight. So there was no point taking it.
6 months later I am now 2 months into my second attempt at taking the drug. I have put 3 pound all together. I walk a mile a day and eat very well.
I feel amazing!
So yes its not the pill but yoyr eating habits and fast your metabolism works.
Hope this helps.
I have definitely put on weight taking 7.5mg ( half tab ) of Remeron. Omg. Carb cravings big time. Never had a weight problem until now, age 45. I do feel better on this med and I am sleeping better but the 25lb weight gain the past year is embarassing. Its in my thighs and stomach. Ugh, really hard to lose when you crave junk all of the time!
I have been on Remeron (Brand) for 8 1/2 yrs and have had no increased weight gain at all. It has helpws me very well in dealing with PTSD and depression. We can all react differently to any med. Luckily I did not gain weight but reaped the benefits in other good ways. I take 30mg nightly now, started at 15mg in the 1st few months. It has been a life saver for me.
I have been on Mirtazepine now for 7 years, I increased to the full dosage of 45mg. I very quickly gained weight, my appetite went through the roof. For someone that actually wanted to gain weight this wasn't a bad thing. If you choose a healthy diet and eat sensible things when you get the cravings for food, it shouldn't be an issue.
Hi, I've been on mirtazapine for 3 weeks and am already putting on the pounds. I have a background in pharmacology so after doing some digging I have came to the following conclusions, which I'll try to keep simplified: an increase in appetite is certainly one aspect of this medication, but unfortunately I suspect that due to the alterations in the levels of a variety of hormones, that weight gain will also be a metabolic phenomenon. What is mean by that is, hormones can send messages to lots of different cells in your body to handle nutrients differently, which in this case means that your cells will be more in "energy saving mode" than before. Because there is more nutrients hanging around, it will start being converted to fatty substances, which ulitmately equates to more weight. The upshot is even if you ate the same amount as before taking the medication, there is a good chance youll still put on some weight.
For me at least, this medication has made me feel emotions I haven't felt in a long time, even when on other meds (joy, excitement, anger etc.) so for me, it is well worth it. I believe I can control it with lots of fruit instead of carb-rich foods, and a good fitness routine. For me this is a worthy compromise and ill probably make myself fitter in the process (win win!). I'm aware this medication isn't for everyone so perhaps I'd have a different attitude altogether if it hadn't helped me so much.
Hope this is helpful and that you refind yourself with this medication. Good luck.
I think it really depends on the individual. In other words, how they metabolize the drug, and their genome.
There is genetic testing available that will actually tell you whether your genes have a protective effect against weight gain, and whether you will experience cravings or not, for the psychotropic drugs. Might be worth looking into.
I'm on 7.5mg of mirtazipine, have been so for about a year, and did experience about a 10 lb gain the beginning. I tried cutting calories for a few months, that did not work. What did work, was making sure I exercised regularly, 5/7 days of the week, moving more throughout the day, and adding in more calories while spreading it out. So instead of eating 3 big meals, I just sort of graze all day. And if I feel a craving coming on, I chew on some gum to distract myself. I lost 5 of the 10 pounds that way, and am happy where I am.
That being said, I have read through the scientific literature, and the weight gain for this drug is supposedly worse than pretty much all other antidepressants. But again, it's possible to not gain any weight at all, or to just gain a few pounds like I did.
I know this post is old, but hopefully my experiences can help someone with their decision.
Cutting calories and working out excessively will not be successful, because this drug screws up the way your body uses insulin and processes carbohydrates.
If you go on a ketogenic (no-carb) diet, you will lose the mirtazapine weight! Pretty quickly, too! And then by keeping a low-carb diet afterwards (finding the balance), it will stay off!!
This drug is GOLD for my anxiety and depression, but gaining 2 lbs/month while eating 1500 cal/day and doing high intensity workouts 5x a week is just NOT sustainable. Anyone who says "oh just eat fewer calories, it's simply physics" is LYING. Okay, sure, all you have to do is take in less energy than is used... but how does that factor when the mirtaz changes the amount of energy your body stores in the first place as well as what types of energy can be used and when?? It's not healthy to cut down to 600 cal/day and starve yourself because your body isn't handling the carbs right.
It IS healthy to trade those carbs out for fats. There's a huge keto community out there and all kinds of fantastic recipes, and there are a lot of health benefits that come from this diet regardless. I'm glad I was forced to find it. Now I'm living a healthier lifestyle, continuing to lose weight, AND I get to keep my mental health!!
Maybe for some people it's the increased appetite or cravings, but for me it was 100% NOT.
This drug is GOLD for my anxiety and depression, but I was gaining 2 lbs/month while eating 1500 cal/day and doing high intensity workouts 5x a week. NOT sustainable.
I was dieting for the first time in my LIFE on this drug. I've always been hella thin. And those HI workouts? First time I've worked out consistently (see: at all,really) in 4 years. I got super fit on this drug... under a huge layer of fat that wouldn't stop growing.
Anyone who says "oh just eat fewer calories, it's simply physics" is LYING. Okay, sure, all you have to do is take in less energy than is used... but how does that factor when the mirtaz changes the amount of energy your body stores in the first place as well as what types of energy can be used and when??
I quickly (lol not really, it took 6 months) found that cutting calories and working out excessively will not be successful, because this drug screws up the way your body uses insulin and processes carbohydrates. If you go on a ketogenic (no-carb) diet, you will lose the mirtazapine weight! Pretty quickly, too! And then by keeping a low-carb diet afterwards (finding the balance), it will stay off!! I'm still on it and (finally) continue to lose weight. But it has nothing to do with the amount of food I'm eating.
(btw if you ARE getting sugar cravings and eating because of that... keto should help regulate ur blood sugar and calm those down a bit too)
I’ve been on 15mg for 4 weeks and put on 12 pounds right away. I am constantly eating any carbs put in front of me. I couldn’t button my pants anymore and started feeling depressed from the weight gain so I stopped. After two days, my carb cravings went back to normal and I wasn’t even hungry (which is my normal).
Went back to the doc today and she says she is going to up my dose to 30mg. She says the higher dose actually lowers the sedative effects and the appetite stimulant (which seems counterintuitive but she went to med school, I did not). I’m going to try this for 3 weeks and then I’ll see her again to report back my findings.
I do have to say that it has had the best impact on my sleep problems and anxiety than anything else. I did have vivid dreams but didn’t wake up groggy. I was able to lower my Xanax from 4 times a day to 3. Also, I take about 30 minutes before I want to go to sleep and once I hit the pillow I’m out.
- Mirtazapine Information for Consumers
- Mirtazapine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Mirtazapine (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Updated 20 Oct 2014 • 4 answers
Updated 28 Apr 2015 • 1 answer
Updated 5 Sep 2015 • 1 answer
Updated 2 Feb 2018 • 10 answers
Updated 17 Feb 2017 • 1 answer