Hi guys. Need help. Have successfully tapered off Seroquel completely after taking it for 4 years. Went from 150mg XR, 100mg XR, 50mg XR, 50mg, 25mg, zero. Each reduction was in place for 2 weeks. No side effects other than extreme itching which began a few days after stopping last dose. I thought it had something to do with Seroquel being an antihistamine, however my GP (who told me he has treated other patients with the itching aftet stopping Seroquel) said it's actually hypersensitive nerves affected by Seroquel. The itching is bearable when I'm still and drinking water helps to alleviate it immediately. 2 to 3 litres per day helps. When I do any activity like walking or start to get sweaty, the itching takes over my whole body and I want to rip my clothes off and scratch until I bleed. Doctor said it has something to do with the sweat glands and nerves so have to now take antihistamines 1 per day to combat the itching. GP says this is short term only for 3 to 4 weeks and to give the nerves time to balance out again. He said the itching can last for up to a couple of months. Waiting to see if after 3 or 4 weeks the itching stops. If not I need to go back and he will investigate further and possibly with alternative treatment. Has anyone else experienced this itching and hiw long did it last until it went away completely? I gained a lot of weight while taking Seroquel and can't even walk let alone exercise properly to lose the weight because of the itching. Thank you in advance.
How long does severe itching last after withdrawing from Seroquel?
Question posted by Lilo81 on 7 July 2014
Last updated on 20 November 2022 (1 week ago) by DaisyMate
I'm 4 days into completing stopping Seroquel 100mg. I was really nauseous for the first couple of days but now I'm so itchy it's been driving me wild & keeping me awake all night arghhh! I've discovered some drug-free coping mechanisms - the first is using a boar bristle hair brush to scratch with, especially my legs and feet. Relieves the itch without damaging the skin & also removes dry skin which helps. The next is Dermacool Plus menthol aqueous cream and this is a LIFE SAVER! The cooling sensation is a bit weird, especially when you're in bed, but it totally soothes the itching and you can reapply as often as you want. It's for eczema & rashes so seems to be okay for sensitive, damaged or broken skin too if you've clawed yourself like me it will help heal the skin as well as preventing itch. Don't rub your eyes with it on your hands though, I learned this the hard way!
I am a month off 20 years of Seroquel. I am on pregabalin for the extreme itch, and it makes it manageable. I hope you don't have to go this route, but just wanted you to know it is out there.
This is a terrible drug, we really need to be careful when doctors or therapists give us pills. There parts easy, they hand them to us and we take them. Their job is done, ours is far worse. I was only on a small dose 25mg for a bout six months, its only been three days now but the itching is horrid. My doctor laughed at me and said the itching is in your head. I was gutted. I know whats in my head and whats not this is so not in my head. I will try something to help with it, be careful folks. My doctor gave this to me regardless of the fact that it can cause diabettes. Scary as he knew from the beginning it runs on my family. I am lucky as I only took 25mg for six months. I can only imagine how bad it is on a higher does. I have always had a low blood pressure as well, suddenly since taking this drug I have a high blood pressure. I am going to try something natural to help wiht anxiety and depression. Sometimes we are just experimental subjects to doctors. Trust your body and yourself folks. Don't be afraid to say no.
Good luck everyone!
I was on seroquel for 12 years. I weaned off 100mg of Seroquel for 5 months and finally quit taking it on Oct. 4th of this year. The bad itching started then! It looks like a skin rash almost, sometimes if I keep scratching a small welt will pop up. I itch on the sides of my face, my hands, and around my knees and elbows. Usually a couple of Benadryl helps but I hate to keep taking it everyday as it makes me tired. A cool shower also helps sometimes. As others have stated an ice pack will help as well. I have also broken out with acne really badly since stopping the meds. Seroquel also made me gain weight so I have lost about 5 pounds already. I'm in the same boat as you with the working out problem, I start to sweat and the itchiness gets very intense, I would take a benadryl before hand but that zaps my energy and I feel like i cant lift much weight. It has been a exactly a month since I've stopped and the itchiness is worse than ever. Hopefully this doesnt continue for much longer
My son is experiencing severe itch as well. He has been off of seroquel for 2 weeks. He was on Seroquel for 10 years up to 1300mg nightly. What can he do for relief?
I had been taking 300mg of seroquel for over 6 years and recently had to get off it because it was causing me bladder issues (it makes it difficult to urinate which has expanded my bladder over the years). I tapered off by 50mg every 3 weeks. Everything was going well until I was completely off. After about 2 days without it, I noticed I was getting nauseous more easily, lost my appetite, was having diarrhea, and was very itchy. I thought I could handle it, but by day 5 the itchiness was just too much. It was primarily on my palms and between my fingers. I ended up going back up to 25mg for another 4 weeks then off again. The itchiness came back worse than ever. As someone posted above, ice packs help a ton! At night it seems to be much worse (it also fluctuates) so sometimes I'll take a vistaril (25mg of hydroxyzine pamoate) so I can fall asleep. To help with the nausea, eating many small meals and drinking lots of water helped the most for me. I'm currently on day 8 without seroquel and still itching, but not as bad. Hope this helps!
I am, currently, on zero quetiapine 25 mg, for a week: I have only experienced physical symptoms like late restless sleep, digestive problems and less muscular strengh; Total lack of appetite and weight loss. However, is the inching that is the most uncomfortable!
hey I was going though the same thing I was scratching for a week straight ended up going to hospital it’s such a horrible feeling I’m taking 800mg and I can’t sleep without it
Just wanted to say that reading through this forum has been a huge help. I'm currently in Seroquel withdrawal and have been Googling ways to fight this intense itchiness. I'm even getting itchy like inside my joints! It's so tempting to just go back on the meds. I read through this forum about those who abstained from taking antihistamines and just letting the itchiness run its course until all the Seroquel is out. I decided to go that route but needed SOME kind of relief. I've found that ice packs actually help. When I need to scratch, applying ice to the areas is a relief. There's also a body oil I've been using that surprisingly helps tremendously. It's olive oil based and the molecules in the oil are a similar size to the ones in our skin, so this oil actually gets into my blood stream through my skin and has anti-inflammatory properties or something.
It seriously helps the itch! I just wanted to reach out and mention this to anyone suffering and in need of some options for relief. Try olive oil, or more specifically the oil I've been using is called Body Oil by Olive + M. It has some other ingredients that I think help a lot. Seriously saving my sanity through this itchy withdrawal period. Good luck and keep pushing through.
Yes!;!! I am going CRAZY AS HELL WITH THIS ITCHING!!! IVE ONLY BEEN OFF SEROQUEL FOR 4 DAYS. BENADRYL IS NOT EVEN HELPING!!!
Hi. I know this is an old thread. This helped me when I was searching. I wanted to give my feedback for people searching for answers like I was. I was taking 200mg of Seroquel for about 5 years. I went down to 100 mg on 1/20/18 and then my doc said to stop it all together on 2/18/18. The first drop was ok. No itchiness at all. Then when I stopped completely, that's when it began! Yikes. It was awful at first. I had severe rashes and itchiness on my lower abdomen, upper thighs, tops of my feet, my upper arms and sides of my breasts. They looked like huge welts. They then got less severe looking... more like a regular rash. I was really concerned. After doing a Google search and finding other people's advice, I learned that Seroquel is an anti-histamine. I began taking 20 mg of equate non-drowsy allergy relief (loratadine) once per day. I also used calamine lotion liberally everywhere needed as much as I needed. I suggest asking your doc how much anti-histamine to take.
I have to tell you that as of today, 2/27/18, I feel like a new woman! I still have some mild looking red marks from the rash and am a little bit itchy but I feel soooo much better. I just want people to know that the horrible part is dying down for me. If anything changes, I'll come back and update. Best wishes to you and God bless.
Lower legs, arms and palms - also ankles for me. I've been off Seroque (after gaining 50 pounds) for months now. Topical antihistamine (like Benadryl cream) does nothing. Started taking double doses of Chlor-Trimeton (Chlor-Tripolon in Canada, generic chlorpheniramine maleate) and eventually it stopped - for awhile. But it keeps coming back. Yes, perspiring is horrible, and if I keep scratching the edge of the ball of my thumb, it's going to start oozing pretty soon. I haven't tried non-drowsy Claritin because with my sleep disorder, non-drowsy is the last thing I need. It's all a shame because Seroquel (quetiapine) can do so much good, but the horrific weight gain side effect is dangerous - I now have diabetes, high blood pressure and high cholesterol. By the way to the person who said he or she went back on 25 mg just to stop the itching - my psychiatrist has told me that the weight gain effect is exactly the same whether you are taking 25 mg or 600. :(
Provided it doesn't mess with anything else you're on, maybe consider aspirin to help. I recommend this in a round-about way: I was on seroquel, and began taking high doses of niacin to help with cholesterol. Occasionally, I got excessively itchy and finally made the connection to the niacin. The recommendation was an adult-dose of aspirin at the same time as niacin, and it worked! Something about the blood-vessel dilation effects.
Some time later I began tapering the seroquel. Once I hit roughly half my old dose, the niacin itching kicked in with a brutal vengeance, aspirin or not, and it drove me crazy, as in not-using-that-word-lightly, for two hours until it passed. Then it hit me: decreased seroquel dose == much lower anti-histamine effect, so the niacin issues masked by seroquel + aspirin were now full-force. I quit the niacin, no choice.
I'd rather go to Rx meds for cholesterol if needed (not yet) But the fact remains that aspirin absolutely helped at one point, and for a while. So, if you're looking to avoid or supplement something like benadryl to not get the soporifics, aspirin might help. Definitely run it by yer doc though unless you already know it's okay to mix in with your medley.
I've been on seroquel for insomnia ever since I was 18. I'm now 23 and have come off it due the gain weight side effect. I came off the drug a week ago and have the same problem but I'm itchy in my legs arms and palms .
I'm trying to go back on it because it helps me sleep and if I do the itchyness may stop. Good luck hope the side effects go away soon.
Hi there, i was on venlafaxine and quentapine, 150g and 300g, for ten years. I finally took the step to come off them this year, for personal reasons, and becuase of the dry skin effect and itching also. I asked the doctor how to do this and suggested coming off 50mg, every two weeks.
I did so, and began to feel effects of slight sickness and sweating. As i came off the quentapine more and more, the effects became worse, even sometimes experiencing hot flashes. Sweating isn't fun espeically when it happens randomnly at inoppurtune moments. Itching also followed (but this was an occuring problem during my entire tretaament and led to many sleepless nights and bleeding unfortunatley). It's hard to focus on day to day jobs when coming off any drugs, but the good news is, if you stick to it and learn what changes occur during the first weeks of reduced dosage you should be able to predict your diet, sleep and withdrawal symptoms. The itching will be there.
You experience this (at least for me) during the last days the absolute worst. It is sometimes unavoidable, but usually the next day you'll be better and not so itchy.
I also drink 3 Litres of water a day. Staying away from sugar and cold milk definitely helps, as well as keeping a low temperature around you, espeically during sleep.
I hope this helps. Good luck x
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