Hi guys. Need help. Have successfully tapered off Seroquel completely after taking it for 4 years. Went from 150mg XR, 100mg XR, 50mg XR, 50mg, 25mg, zero. Each reduction was in place for 2 weeks. No side effects other than extreme itching which began a few days after stopping last dose. I thought it had something to do with Seroquel being an antihistamine, however my GP (who told me he has treated other patients with the itching aftet stopping Seroquel) said it's actually hypersensitive nerves affected by Seroquel. The itching is bearable when I'm still and drinking water helps to alleviate it immediately. 2 to 3 litres per day helps. When I do any activity like walking or start to get sweaty, the itching takes over my whole body and I want to rip my clothes off and scratch until I bleed. Doctor said it has something to do with the sweat glands and nerves so have to now take antihistamines 1 per day to combat the itching. GP says this is short term only for 3 to 4 weeks and to give the nerves time to balance out again. He said the itching can last for up to a couple of months. Waiting to see if after 3 or 4 weeks the itching stops. If not I need to go back and he will investigate further and possibly with alternative treatment. Has anyone else experienced this itching and hiw long did it last until it went away completely? I gained a lot of weight while taking Seroquel and can't even walk let alone exercise properly to lose the weight because of the itching. Thank you in advance.
I would like to say I know the answer to it but I dont . For the longest time I didnt know what was causing my severe itching . I finally figured it out this year .. Looking back at all the timese I had itching problems I was not taking seroquel . They did not give seroquel while I was in prison and in jail . During myu stays there I would itch like CRAZY. It wasnt ubtil this year when I had been taking benedryl all the time for the itching but then had to stop benedryl becuase the court wouldnt allow us to take it . I decided to fill my seroquel just in case the court wanted a list of my meds ..Needless to say after I started the seroquel I havent itched since until the other day when i ran out of my seroquel and these past few days have been horrible . I have been Itching so so bad until right now . I just took my seroquel and what do you know? Im not itching anymore . My experience with stopping seroquel for 15 months while in prison is that I itched the whole entire time .
I think seroquel makes permanent changes in the brain and how histamines are made and released.Not sure but the makers of this drug owe me compensation.Has your itching has stopped or got better let me know . Thank, David Sp
hi .I stoped using qutiepine after 3 YEARS CHOSE to cold turky.and yes the dreaded itching started within a day of my last dose.it was really severe never experienced any thing like it horibble .even inside my eyes were itchy.so I decided to take a piriton tablet and within seconds relief .Unfortunately the itching started again the next night so I did the same thing and it worked again so I have been taking two piriton tablets a day .one when I get up to prevent .and one at night when it starts .great .it works so do this and you wont have the terrible itch .
good luck and stay with it.
I had been trying to cut out seroquel for a few months. I tapered down, but the itching got so bad that I always went back up to like 25 mg. I found the answer: Claritin 24 hour non drowsy. I know your doctor told your doctor told you differently, but Claritin simply works. Try it and you'll see what I mean. You can also check out the Wikipedia page for Claritin to see why it may work. I'm not a doctor, but it works. Try it.
I was taking seroquel from about 2008 until 2012. I stopped taking it abruptly in 2012 and the itching started. I soon figured out that benadryl stopped the non stop itching.
After taking benadryl with great results for a couple months I decided to stop and see if it would go away naturally without meds. After about 2 weeks of itching it finally went away!!
About a year later I had a bad cold and took nyquil for maybe 2 or 3 nights. The itching returned with a vengance. I have been taking benadryl (and then Claritin 24 hour non drowsy) ever since.
About a week ago I decided to stop taking the meds again and now I'm waiting for it to go away on its own again. Today is about day 8 and the itching is is still going strong.
I just wanted to share my experience so you people know NOT TO TAKE ANY ANTIHISTAMINES after the itching goes away. It will come back!!
And for those of you currently taking antihistamines for this, I would highly suggest a 24 hour non drowsy med. Benadryl made me feel sluggish all through the day (even after taking it for over 2 years.)
It is easier to get through the itch withdrawals if you ignore the itches the best you can. The second you scratch an itch it just gets worse. I wish all of you the best of luck. I will update when I am finally itch free again.
Hi there, i was on venlafaxine and quentapine, 150g and 300g, for ten years. I finally took the step to come off them this year, for personal reasons, and becuase of the dry skin effect and itching also. I asked the doctor how to do this and suggested coming off 50mg, every two weeks.
I did so, and began to feel effects of slight sickness and sweating. As i came off the quentapine more and more, the effects became worse, even sometimes experiencing hot flashes. Sweating isn't fun espeically when it happens randomnly at inoppurtune moments. Itching also followed (but this was an occuring problem during my entire tretaament and led to many sleepless nights and bleeding unfortunatley). It's hard to focus on day to day jobs when coming off any drugs, but the good news is, if you stick to it and learn what changes occur during the first weeks of reduced dosage you should be able to predict your diet, sleep and withdrawal symptoms. The itching will be there.
You experience this (at least for me) during the last days the absolute worst. It is sometimes unavoidable, but usually the next day you'll be better and not so itchy.
I also drink 3 Litres of water a day. Staying away from sugar and cold milk definitely helps, as well as keeping a low temperature around you, espeically during sleep.
I hope this helps. Good luck x
I've been on seroquel for insomnia ever since I was 18. I'm now 23 and have come off it due the gain weight side effect. I came off the drug a week ago and have the same problem but I'm itchy in my legs arms and palms .
I'm trying to go back on it because it helps me sleep and if I do the itchyness may stop. Good luck hope the side effects go away soon.
Provided it doesn't mess with anything else you're on, maybe consider aspirin to help. I recommend this in a round-about way: I was on seroquel, and began taking high doses of niacin to help with cholesterol. Occasionally, I got excessively itchy and finally made the connection to the niacin. The recommendation was an adult-dose of aspirin at the same time as niacin, and it worked! Something about the blood-vessel dilation effects.
Some time later I began tapering the seroquel. Once I hit roughly half my old dose, the niacin itching kicked in with a brutal vengeance, aspirin or not, and it drove me crazy, as in not-using-that-word-lightly, for two hours until it passed. Then it hit me: decreased seroquel dose == much lower anti-histamine effect, so the niacin issues masked by seroquel + aspirin were now full-force. I quit the niacin, no choice. I'd rather go to Rx meds for cholesterol if needed (not yet) But the fact remains that aspirin absolutely helped at one point, and for a while. So, if you're looking to avoid or supplement something like benadryl to not get the soporifics, aspirin might help. Definitely run it by yer doc though unless you already know it's okay to mix in with your medley.
Lower legs, arms and palms - also ankles for me. I've been off Seroque (after gaining 50 pounds) for months now. Topical antihistamine (like Benadryl cream) does nothing. Started taking double doses of Chlor-Trimeton (Chlor-Tripolon in Canada, generic chlorpheniramine maleate) and eventually it stopped - for awhile. But it keeps coming back. Yes, perspiring is horrible, and if I keep scratching the edge of the ball of my thumb, it's going to start oozing pretty soon. I haven't tried non-drowsy Claritin because with my sleep disorder, non-drowsy is the last thing I need. It's all a shame because Seroquel (quetiapine) can do so much good, but the horrific weight gain side effect is dangerous - I now have diabetes, high blood pressure and high cholesterol.
By the way to the person who said he or she went back on 25 mg just to stop the itching - my psychiatrist has told me that the weight gain effect is exactly the same whether you are taking 25 mg or 600. :(
Hi. I know this is an old thread. This helped me when I was searching. I wanted to give my feedback for people searching for answers like I was. I was taking 200mg of Seroquel for about 5 years. I went down to 100 mg on 1/20/18 and then my doc said to stop it all together on 2/18/18. The first drop was ok. No itchiness at all. Then when I stopped completely, that's when it began! Yikes. It was awful at first. I had severe rashes and itchiness on my lower abdomen, upper thighs, tops of my feet, my upper arms and sides of my breasts. They looked like huge welts. They then got less severe looking... more like a regular rash. I was really concerned. After doing a Google search and finding other people's advice, I learned that Seroquel is an anti-histamine. I began taking 20 mg of equate non-drowsy allergy relief (loratadine) once per day. I also used calamine lotion liberally everywhere needed as much as I needed. I suggest asking your doc how much anti-histamine to take.
I have to tell you that as of today, 2/27/18, I feel like a new woman! I still have some mild looking red marks from the rash and am a little bit itchy but I feel soooo much better. I just want people to know that the horrible part is dying down for me. If anything changes, I'll come back and update. Best wishes to you and God bless.
I think I figured out something very important. Everybody talks about seroquel itch right? That terrible itch we know all too well? Well it should be referred to as seroquel inflammation! The inflammation is what causes the itch. Inflammation can be caused by pathogens that the body cannot break down or overactive immune responses. People will feel pain, stiffness, discomfort, distress, and even agony, depending on the severity of the inflammation. The type of pain varies. It can be described as constant and steady, throbbing and pulsating, stabbing, or pinching. Inflammation primarily causes pain because the swelling pushes against the sensitive nerve endings. This sends pain signals to the brain.
So how can you deal with the this terrible, pain-inducing inflammation?
Ibuprofen!!! I strongly recommend Ibuprofen as opposed to taking more antihistamines. Think about it. Seroquel is an antihistamine. What happens when you're body gets used to all these antihistamines and then you stop taking seroquel completely?Histamine overload! Which causes overactive immune responses which causes Inflammation which causes seroquel itch! So dont go and take more antihistamines - you'll never get over your histamine dependance that way! Take Ibuprofen until the itch goes away on its own. Even if it takes months or more... I did hours and hours of research to get to this point but I finally think I have it all figured out. Ibuprofen yes. More antihistamines no. I'm officially a doctor!
Just wanted to say that reading through this forum has been a huge help. I'm currently in Seroquel withdrawal and have been Googling ways to fight this intense itchiness. I'm even getting itchy like inside my joints! It's so tempting to just go back on the meds. I read through this forum about those who abstained from taking antihistamines and just letting the itchiness run its course until all the Seroquel is out. I decided to go that route but needed SOME kind of relief. I've found that ice packs actually help. When I need to scratch, applying ice to the areas is a relief. There's also a body oil I've been using that surprisingly helps tremendously. It's olive oil based and the molecules in the oil are a similar size to the ones in our skin, so this oil actually gets into my blood stream through my skin and has anti-inflammatory properties or something.
It seriously helps the itch! I just wanted to reach out and mention this to anyone suffering and in need of some options for relief. Try olive oil, or more specifically the oil I've been using is called Body Oil by Olive + M. It has some other ingredients that I think help a lot. Seriously saving my sanity through this itchy withdrawal period. Good luck and keep pushing through.
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