I have depression, anxiety, and ADHD. I take Xanax for occasional anxiety and Concerta for ADHD. I've been on just about every antidepressant there is for depression. The latest were Cymbalta and Pristiq. Pristiq makes me just kind of Blah. Really don't want to do much. I took Cymbalta a few weeks ago and almost immediately felt motivated! However, I didn't really want to act on it very much. For some reason or another, I quit taking Cymbalta (going off was terrible). I'm back on Pristiq and still have the Blahs. My psychologist suggested adding Wellbutrin, but my nurse practitioner said no--too much serotonin. She said Zoloft and Wellbutrin. I don't want to take Zoloft because of the side effects and I'm afraid to take Wellbutrin because of the anxiety side effect. Many years ago, not long after I was first diagnosed, I took Prozac and Wellbutrin. They worked wonders! I tried that combination again several months ago and was terribly agitated about EVERYTHING! I've read about some conjunctive therapies for Pristiq, but don't know what to suggest to my doctor. I also have a hard time getting to sleep sometimes (my mind won't shut off, but I can sleep for hours once I get to sleep), and I can no longer take my beloved Ambien because of sleep apnea. I just changed clinics but I'm thinking of going back to the old one. My gene test says Pristiq is the best for me, Wellbutrin is in the "ok" column, and Cymbalta is in the last "must watch" column. I've just got to have some relief and I'm at my wit's end!