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How long does it take for suprep to work?

92 Answers

Official Answer by 3 Sep 2018

Suprep is a type of osmotic laxative that is used for cleansing the colon before a colonoscopy procedure in adults. Thorough cleansing of the colon is essential as it allows your doctor to see the mucosal lining of your colon.

The length of time it takes for Suprep to act and the duration of the action appear to be quite variable. Some people have a bowel movement within minutes while others take hours. Make sure you drink the entire bowel prep solution. You can tell when your bowel is ready for the procedure when your stool is clear, yellow, light and liquid.

If you have not had a bowel movement within three hours of drinking your prep call your doctor. You may need another laxative.

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cintrix 22 Dec 2023

For me the first dose was at 5pm (took 20 minutes to get it down with the extra water) and started working at 6:40. My second dose was at 3am (took a little over 30 mins to get it all down this time) and started working at 4:50am. If you have an early appointment I suggest you take that second dose early - especially if you live over ten minutes from the procedure location.

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Gobengals 13 Jan 2022

I've had 7 colonoscopies. (I have Crohn's that is in remission.) This prep is one of the more pleasant ones, although I felt a little bit nauseous. From past experiences, bought some Desitin for diaper rash, which works very well. Downed the prep in two parts - 15 minutes between. My procedure is scheduled for 8:00 am. Took first dose at 5:00 pm followed with the 32 oz. of water. Took about 45 minutes before first trip to the bathroom. It's now 7:30 pm and have gone 4 times. Not feeling any of the urgency described by others who have spent an hour or two in the bathroom. My next dose is at 2:00 am. I did eat a high fiber diet for the previous two days, which cleaned me out fairly well. I'm not looking forward to the second dose. It could be a long night. I don't plan to sleep much... don't want any accidents. Have to leave for the procedure at 6:20 am. Hope this helps someone.

Votes: +0
Butterflies212 1 Dec 2021

For me it took 45 min to take effect
I’ve been on a fast for the past 2 days as my own prep.
I took first dose at 4:00. It was torture for me. It tasted like grape sea water. I drank 32 oz of water over the next 1/2 hour. After every gulp of the prep I chugged life water-It contains electrolytes and is Ph balanced. I Have been in the bathroom for the past 3 hours. It’s now clear. Next dose is at 11:00 tonight. I dread it. I’m very bloated, no cramping, I’m cold, have a bad headache and am feeling very tired and weak. This is an exhausting procedure mixed with anxiety for me. I don’t want to mess up with the prep and be sent home without a scope. This is my 2nd one. Last time I had that big gallon jug. I didn’t think that was too terrible until the last hour. it’s 2021 and this is still torture. But it’s a necessary procedure. I’m doing this as a routine screening. The dr said if this is as good as the last time six years ago then I won’t have to have another for 10 years.

Votes: +1
bestpunkin 28 Oct 2021

Per provider instructions I was on clear liquid diet all day yesterday. I started 1st dose of Suprep last night at 18:00, followed by 32 oz water within an hour. The liquid prep tastes nasty, even though sort of grape flavored, but I tried to gulp it down as fast as possible. I was nauseated and bloated for several hours. Started working about 2 hours later at approx 20:15. I was in the bathroom 90 minutes straight. Pretty much diarrhea from the get go. Then off/on diarrhea until 23:30. Diarrhea was cloudy deep yellow at that point and my bumhole is swollen with burning tenderness. Set my alarm for 04:00 to drink 2nd dose of prep and did get up 3 times again before the alarm went off this morning.


Got up at 04:00 this morning, and drank 2nd dose of Suprep followed by 32 oz water by 05:00. Kicked in at 04:45 actually. It’s 06:05 now and I’m still on the commode. It’s still cloudy deep yellow water ejecting out. No cramping but my bumhole is screaming. Just hoping my Colin will be clear enough for today’s Endoscopy and Colonoscopy at 10:15. Was hoping to sleep for another hour before getting up to shower again and go. Not sure if my gut will let me do either of those.

I will say that as far as drinking Suprep, it’s more tolerable than the other Golytly gallon prep for sure.

Votes: +0
Mmadsen 31 March 2021

Using this is so easy. Slam it! It’s no big deal. Works fast. I started at 6pm, was voiding in 20 minutes. All urges were completely gone by bedtime. I slept well. Started again at 6 am and found that completely easy as I was . . . Pretty much empty. Hardest part was containing the giggling (think Dumb and Dumber) and this prep will be a snap!

Votes: +1
muggled 12 Dec 2020

The day before my procedure I only ate jello, chicken broth, Sprite, and had one mug of tea with honey. It was not great.

I took my first prep at 8pm and the second the next morning at 8:30am for a 2:30pm procedure. I drank the first mixture all in one long chug to get it over with, followed up with the two 16 oz cups of water over the next 90 minutes.

The first prep did not do much until about an hour later, and that was a roughly normal bowel movement. Maybe a half an hour after I had another that was still pretty normal, though a little more lubricated than normal. After that nothing other than gurgling and feeling bloated all night.


After the second prep, which was much harder to swallow, the result was about the same though my stools started to be more like diarrhea. I finished up the water by 10:30 and had nothing afterwards. This was my first colonoscopy, and I didn't know this was unusual. On the way to the doctor's office I started feeling more rumbling. I went right away when I got there at 1:45 and twice again before the procedure. That was more of what I'm reading here. Very forceful and liquid. Unfortunately later the doctor said most of my colon was not clean so he couldn't scope very far.

The real fireworks came the next day after my procedure. I probably went to the bathroom 10 times. Fortunately I was working from home and not far from the bathroom. This was super annoying. Basically the Suprep hit about 24 hours too late. So I had a day of no solid food and Suprep, a day with a failed colonoscopy and groginess from the anesthesia, and a day of explosive diarrhea. I am not excited to ever use Suprep again. I did not have a high fiber diet the days before the prep started, either. I think I ate an apple and a small side salad the day before prep started, but that's it beyond stuff like pasta, bread, and yogurt.

Right after the procedure when I woke up the doctor said my experience happens like 2% of the time. Not sure if that includes Suprep hitting a day late, too. Ugh.

Votes: +0
Eagle Eye2 12 Nov 2020

The first 16 oz. bottle and water dose was taken at 8 p.m. This first dose was followed by the supplied container filled with water to the line two additional times. Since I was to drink two containers of water within the hour of the first dose, I spread it equally over the hour in 20 minute increments. One was at 8:20 p.m. and the other was at 8:40 p.m. About 9:55 p.m., my system began cramping a little and started intermittently flushing. It was quite frequent to begin with, but began to slow down somewhat about 10:40 p.m. At 10:55 p.m., the flushing of my system has slowed down considerably, but has not stopped as yet. The water in the toilet is still dark after each bowel movement. I will take the second dose in the morning.

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leighannl 3 Sep 2019

My first colonoscopy was a complete success and a Boston Bowel Prep score of 9. I admit ,I was really was dreading taking Suprep. Here is a great combination of flavors that make it tolerable.. I mixed the solution with 7-Up and a splash of lime, hardly a gin and tonic, somehow I managed to keep both doses that are required and the water down without any problems. I warn anyone that already has issues with IBS or chronic diarrhea to be prepared , Suprep gets results quickly. It was a manageable 2 hours of watching my iPad on the toilet and a full nights sleep. Second dose in the AM is a little harder to swallow, but no vomiting, cramping, or any other adverse side effects. I highly recommend this for a clean colon, meaning a much better polyp detection. People that don’t finish the prep don’t realize that they are just cheating theirselves.

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ImFatso 12 Aug 2019

It took an hour for it to take full effect. And a solid hour n and half of needing to stay close the bathroom. I thought the taste was awful and am not looking forward to the 2nd batch.

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GSDMUM3 22 July 2019

It took me about 40 minutes before it started to work. I was ice cold so you may want to keep a warm robe nearby. To make the first glassful palateable, after each few gulps, take a swig of 7-Up. This will counteract the saltiness of it. I felt bloated to the max after the 3 cups fulls and weak but still have to look forward to the second morning dose.

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GALisa 4 April 2019

I was able to drink the prep mixed with cold water quickly followed by the 32oz of water over the next 15 minutes. My first movement was within 15 minutes of the first drink and had several visits over the following 3 hours. Tips: Wear warm socks, have a blanket heated in the dryer available to wrap up in - you will feel cold and weak! Fresh ginger tea with honey really helped with relieving nausea. For prevention and relief of soreness, I used pure aloe cream before treatment and after each movement.

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Ltyler92 3 April 2019

I am 26 years old and I just started drinking the surprep at 4pm finished at 4:48pm and then it took effect at 5:14pm it just like you peeing out of your bottom so stay close to the toilet because is you think your done your not and i just started this surprep today at 4pm

Votes: +0
barrydshaffer 21 March 2019

I took my first dose at 5:00pm followed by the required water (taken within about 15 minutes of the Suprep) and had the desired response by 6:30pm. That continued for about 2 hours during which several times I had to stay very close to “the throne”. Slept well. Took my next dose at 4:30am followed immediately by the required 2 - 16 oz waters and got a quite liquid response by 5:45am. This continued off and on with longer periods of time between responses until right before my appointment at noon. NOTE: I am a cancer patient and due to pancreatic insufficiency (I suspect a response to Opdivo), I have been taking enzymes to digest my meals. When I woke in recovery from what was supposed to be a colonoscopy, I was told by my doctor that she had been unable to complete the colonoscopy due to there being residual stool throughout my colon and enough stool right near the end to stop the procedure.


She did some biopsies along the way but I will have to reschedule the colonoscopy. Bummer! Next time, they plan either to increase the amount of prep or take me off the enzymes 2 days before. I hope this helps someone. Other than this minor hiccup, I liked the Suprep much better than other preps. There was no cramping, and it worked well. I think it was my situation that complicated it for me.

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Ctowalski 10 March 2019

It started one hour after drinking the 1st dose. Then I was incontinent for 7 hours. Couldn't sit long on the toilet because it hurt my back and my legs would fall asleep. I was brought Depends and a special pad for fecal incontinence but leaked anyway. I have had a terrible experience with this. Doctor said it's a gentle one and I must have a sensitivity to it. Also, I'm doing it because I'm having a hysterectomy.

Votes: +0 free discount card

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colonoscopy, suprep, laxative

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