How does Rexulti work?

Rexulti (generic name: brexpiprazole) is an atypical antipsychotic medication used to treat schizophrenia and combined with other medicines for the symptoms of major depressive disorder.

Rexulti works by altering chemicals in the brain that can lead to schizophrenia or depression.

Rexulti is classified as a serotonin-dopamine activity modulator (SDAM) and works at serotonin and dopamine receptors in the brain. It is considered a second generation version of aripiprazole (brand name: Abilify), but has slightly different activity at the serotonin and dopamine receptors which may reduce certain side effects such as restlessness.