How does Rexulti work?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on May 18, 2023.

Official answer

by Drugs.com

Rexulti (brexpiprazole) works by altering chemicals in the brain that can lead to schizophrenia or depression. Rexulti is an atypical antipsychotic medication approved to treat:

schizophrenia
symptoms of depression (major depressive disorder) when used with other medicines
agitation associated with dementia due to Alzheimer’s disease.

Rexulti is classified as a serotonin-dopamine activity modulator (SDAM) and works at serotonin and dopamine receptors in the brain. It is considered a second generation version of aripiprazole (Abilify), but has slightly different activity at the serotonin and dopamine receptors which may reduce certain side effects such as restlessness.

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at increased risk of death. Rexulti is not approved for the treatment of patients with dementia-related psychosis.

Safety and effectiveness of Rexulti in children have not been established.

Rexulti is given orally, once daily with or without food.

Note: Limitations of Use: Rexulti is not indicated as an as needed ("prn") treatment for agitation associated with dementia due to Alzheimer’s disease.

This is not all the information you need to know about Rexulti (brexpiprazole) for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full Rexulti information here, and discuss this information and any questions you have with your doctor or other health care provider.

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Not being able to sleep (also called insomnia) is one of the most common side effects reported by people taking Cymbalta. In some people, this side effect improves after a couple of weeks of taking Cymbalta, but difficulty falling asleep or staying asleep can persist in others. Here are some ways you can improve sleep while taking Cymbalta:

Take your dose of Cymbalta in the morning. Cymbalta may be given once a day or twice a day but for those people experiencing insomnia, it should be taken just once a day in the morning
Swallow Cymbalta capsules whole; do not crush, chew, or open up the capsules and sprinkle them on food because this may cause Cymbalta to be absorbed more quickly than intended, increasing the risk of side effects such as insomnia...

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