I am starting my 5th week of Wellbutrin XL (150 mg). Generally, I am opposed to taking medications but my depression has really knocked me off my feet- crying, sadness, anxiety. I feel a little better but not sure if it's the weather or the drug. I had a lot of nausea, still some anxiety but don't feel much in the way of side effects now but still feel a little low. Any comments or suggestions would be helpful. Thanks.
Hi, I would expect you to be feeling a bit more relief from your depression and anxiety quite soon. Usually we are told that the first 4 weeks are the induction phase and after these 4 weeks is when we get relief from our symptoms. Of cause it can take longer in some people and considering you are just starting your fifth wk you may just have to try to hang in there a little longer. If you still feel no better after another week, discuss this with your doctor. Wellbutrin is a good anti-depressant on its own, but can also be used with add on meds so maybe this would be an option for you? Have you ever used an ssri? Let us know how you're getting on : )
As Delila said the Wellbutrin reaches its maximum effectivenessa around 4 weeks or so. Are you taking just one XL 150mg a day? You may be increased to 2 pills a day. I take Wellbutrin XL 300 mgs a day along with another antidepressant, Pristiq, with fantastic results. If you are still feeling symptoms of depression such as crying and general low feeling then discuss increasing the Wellbutrin to 300mgs a day, unless you are already on that dose, or adding a low dose of another antidepressant. That is one of the nice things about Wellbutrin, you can take it with other antidepressants.
I would think that your overall ability to function would improve, if you don't eat much that might tend to be improved, your mood with depression is affected and you don't really feel like doing anything I would expect you to feel like doing some things that you just didn't feel up to doing, maybe you will find that some of the effects of nausea, sadness, just that low feeling should continue to improve, It is my sincere hope that you soon start to notice things like this happening and you soon feel lots better! I hope you feel better soon
I've been taking the generic of wellbutrin xl for 3 weeks now (150mg). I felt positive effects from it around the fifth day of taking it however I have a very high metabolism so it seemed to level off after two weeks. I was still feeling down and crying for no reason so the dr went ahead and incresed my dosage to 300mg. We'll see if this works, but I have to say, it has helped me to have more energy. I actually get out of the house now besides going to work. Good luck!!
Anyone having issues with high blood pressure.? This is one of the side effects. I just started 150 XL generic today. Im on 6th Anti-depressant.
The shift from escitalopram to wellbutrin has CERTAINLY made a change in my ‘awareness’ of the world around me, my ‘consciousness’, yet I’m not very sure as to what has changed exactly. I’m MUCH less of a zombie, so much less tired as I was on escitalopram, my motorics are quicker and I’m more active in general. I simply want to do things. But there is also an element of increased restlessness, perhaps anxiety, but it may well have to do with my dosage, which I’m still trying to find out. I have picked up reading again quite easily, which with escitalopram I was simply not interested in, I was like too tired and my afternoons here in the tropics were just lying there on my thin floor mattress, mostly in a half awake, half asleep state.
As I wrote, two days ago, my anxiety-level was pretty bad and I wasn’t sure if I’d continue on Wellbutrin, but for now I see it differently again, and I’ll try a week or so on 75 mg and see what happens. Of course, it’s a pleasure to be so much more alert again, the things around me stand out so much crisper and clearly again and it has nothing to do with the weather I guess. When I look at my laptop, I see it much better, the color, the texture, the light on it, the dust on it. What I do feel as a quite negative element is that I seem to be a little more socially unsure. But perhaps I can work on this, perhaps I’m guessing I’m a bit more paranoid.
I find it helpful to review experiences from introspective and educated people with similar situations with which to create an algorithm to make choices for myself. So maybe I can help others.
Brevity isn't a strong suit of mine, because I think the details are what matters but I'll try my absolute best.
(I've deleted two versions of paragraphs in an attempt to cull confusing details... I thought they were useful, but this probably isn't the place)
So, I've been on Bupropion for... 3 weeks now. 150XL. Took a TON of convincing from my doctor who initially tried to get me on Lexapro because I've come in for exhaustion and heart palpitations.
I thought the DOCTOR was nuts for trying to prescribe that for chest pain (followed up with cardiologists - clean bill of health except minor early heart beats). Which I've been to the hospital for on other occasions (I'm a relatively young and healthy man so each time nothing comes up and they talk to me about stress) (Part of deleted paragraphs. I also have a severe form of IL-1 Gene from a test I took 12 years ago, I think this is biologically related so look it up if you wish)
So, no one know me here, but my wife does and some other close people. I don't come to snap decisions often, things are over analyzed to give me a best approach to a problem. I thought Bupropion might help. So I agreed to the medication.
I can unequivocally attest that, despite other things I've read you can feel affects within the first hour of taking your first pill... (More on that later)
Now the severity changes so don't think I mean max effect that fast, but you can feel a change if you are an analyzer like I am... Even when I try to ignore changes, like I did, I'm not one of those people that expect, then feel because of the expectation. I'm not.
-Affects/Side effects (I get everything from everything. Even Zinc and Magnesium make me angry and agitated but has the benefits to it too... I don't know why)
These came in waves increasing to day 3. I experienced increased in motivation and concentration for literally about 3 hours day one (that never came back) dizziness, slight but welcome numbness.
I noticed the "noise" in my head was like, gone... It was peaceful and quiet, and I no longer was wrecked from ruminating thoughts. I had severe headaches. Which peaked about day 3-5. I had heart racing issues. (Surely from the norepinephrine) On day 3 I was going to stop taking it, because they were bad. Short of breath, no endurance at all. It felt like when I was under the full effects in my youth from my IL-1 genes (when I was going to the gym or had adrenaline run through me)...
I ... DID experience IMPROVED sleep, substantially. (This is still in effect actually)
Dreams were only slightly more memorable, no change in severity or content.
Also... Um. Literally after the first day I noticed improved blood flow in... Other areas. Ahem.
That literally subsided after day a couple of days and went back to normal during reasonable situations which is fine.
However, 3 weeks in, my desire has been drastically reduced, which is unexpected. :Shrug:
I will have to say 1 week in, or even less. I felt more normal. I was desiring to play with my children. I felt like I had a bit more energy to do things. I felt motivate to attend church, read my Bible, and do what I could to serve Christ and my neighbor - if that makes sense to others out there. That was MOST welcome for me.
So 1.5 weeks in. Most of the side effects were gone, there were no positive secondary effects anymore, but I felt more normal. I was thinking that this might really work, because I didn't FEEL anything, except, I processed things more normal (for me) so I was quite pleased...
2-2.5 weeks in. I've noticed what the doctor considers depression symptoms coming back. So right now I'd say that the medication is about 15% effective and reducing about 5 more percent a day if I had to quantify it.
So, about the metabolism as Ive mentioned earlier. I am a fan of finding HARD evidence of things rather than take speculation from doctors who don't know my mind or body as well as I do. So I've tracked down another genetics test which I'm sure will sell out my genomic structure to some pharmaceutical unfortunately (like your 21 and ancestory businesses do - don't take those) that will actually test for pharmaceutical metabolic ratings, and can tell if you have Serotonin mechanism issues (which I don't think I have, but who knows).
Because I will say I've read things where people said they noticed effects after 3 days and everyone (including professionals) claim that is impossible. All the way to, I took it and it never did anything.
For me, everything happened. What does that mean? I don't know. Does it "burn out" receptors? I don't know, is that why I don't respond to the medication anymore? OR, will Genesight's test show that I either can't metabolize (maybe that's why I felt the effects, it spiked in my blood stream and I couldn't clear it fast enough until my body's enzyme production could eliminate it) OR do I metabolize it much too quickly and therefore the dose is too low.
I NEVER throw the easy way out at anything to fix it. I'm not the guy that lets the mechanic throw parts at a car to "fix" a problem. I research it and diag it myself until I am quite certain I can solve the problem with the least resource...
Hence the Genesight test.
So. Sorry for all of this rambling, but if anyone has questions, I literally signed up to try and talk to others about this medication - just for this. I don't take ANY other medication and I have only taken one SSRI about 4 years ago for 2 months that had disasterous effects on me... Everything else I steer away from and live a normal life. I don't do drugs never have. I rarely drink at all. Just some coffee or an energy drink or two a week if that helps anyone relate.
I took Wellbutrin SR successfully for over 20 years. It was the best antidepressant I ever took that didn't cause low libido or weight gain. But it started to exacerbate my anxiety this past year when I took it, so it was not working for me anymore. In the beginning, it would make me more anxious until it settled in, then it gave me energy and motivation. I seemed to develop problems with it when so many generics came out on the market to replace the brand name Wellbutrin. The time release mechanism is not the same, so it would not release any of the med at certain points in the day, and at other times, it would dump too much into my system all at once. Therefore, the problem with my anxiety on the generics of it. I recently was prescribed Trintellix, which was great, but ultimately I could not tolerate the side effects. In the meantime, I will stick with my "tried and true" Buspar.
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