The plasma half-life of levodopa is about 50 minutes, without carbidopa. When carbidopa and levodopa are administered together, the half-life of levodopa is increased to about 1.5 hours. At steady state, the bioavailability of carbidopa from SINEMET (carbidopa-levodopa) tablets is approximately 99% relative to the concomitant administration of carbidopa and levodopa.
With regars to the side effects, can you let us know which ones you are experiencing in order to give you the right answer?
See Also: Drug Half Life Explained
- Sinemet Information for Consumers
- Sinemet Information for Healthcare Professionals (includes dosage details)
- Side Effects of Sinemet (detailed)
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