I started this medicine 2 weeks ago. Recovering from depression and anxiety episode. I get these every 4 to 10 years when difficult situations arise. Was on Zoloft for 12 years then on Luvox for 4 years. I have 2 family members that are doing well on 150 and 225 mg so my doc decided to give it a try. I feel less anxious and depression is lifted. I would like to hear positive responses from Effexor users on how long it took for sleep and the jitters to go away. I see many people posting these side effects but then they went away over time. Can current successful users post if they had this side effect and how long it took to feel completely calm inside? Like I said I'm about 60 percent better in 2 weeks starting my third. I have less negative thinking too but not completely gone.