Interactions between your selected drugs
No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.
Other drugs that your selected drugs interact with
Flexeril (cyclobenzaprine) interacts with more than 300 other drugs.
Ortho Tri-Cyclen Lo (ethinyl estradiol/norgestimate) interacts with more than 300 other drugs.
Interactions between your selected drugs and food
ethinyl estradiol ↔ food
Applies to: Ortho Tri-Cyclen Lo (ethinyl estradiol/norgestimate)
The coadministration with grapefruit juice may increase the bioavailability of oral estrogens. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall induced by certain compounds present in grapefruits. In a small, randomized, crossover study, the administration of ethinyl estradiol with grapefruit juice (compared to herbal tea) increased peak plasma drug concentration (Cmax) by 37% and area under the concentration-time curve (AUC) by 28%. Based on these findings, grapefruit juice is unlikely to affect the overall safety profile of ethinyl estradiol. However, as with other drug interactions involving grapefruit juice, the pharmacokinetic alterations are subject to a high degree of interpatient variability. Also, the effect on other estrogens has not been studied.
I have researched 2 thick books and the site on here I find no problems with the combination but I don't want to take the chance of them not including everything call the doctors office and please run this by them or use the pharmacist Just to be sure I want the best for you and so do the others on this site
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