Hi all, Citalopram & Omeprazole question?

Question

I have just been told by a member of the site, that you shouldn't take the 2 together, that the Omeprazole causes the Citalopram to stay in the blood stream longer, & could potentially cause serotonin overdose... Has anyone else heard this? I checked for interactions & nothing came up

Answer

I do not know if one medication should be taking with another medication. But I can assure you that Celexa ''Citlalopram'' and Omeprazole, are Two completely different drugs, one is used for stomach problems, '' such as a gas build up or a proton pump inhibitor can be used in the treatment of dyspepsia and also ulcers. And Celexa is an Antidepressant. So if no one else answered your question, to your satisfaction, I would just call the DR first thing tomorrow. .
Good Luck To you.

Answer

Hi D, it may depend on the dosage you are given of each drug, & you should check with the prescribing doctor. Most people are not on 400mg of omeprazole a day. More like 20 mg., & it also depends on the dose of citalopram you are on also. As long as your doctor is aware of the inter-reactions of these two drugs, I would personally take his advice on what to do. M

Answer

The information you have been given is correct. Here is a link for you.  https://www.drugs.com/drug-interactions/celexa-with-omeprazole-679-335-1750-0.html

Answer

Hi, Delila! I copied this from the drug.com Interactios Checker:

Interactions between your selected drugs
omeprazole ↔ citalopram

Applies to: omeprazole, citalopram

Talk to your doctor before using citalopram together with omeprazole. Combining these medications may increase the blood levels of citalopram and increase the risk of certain side effects, including an irregular heart rhythm that may be serious or life-threatening. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Votes: +2

Answer

I have another interaction checker and found what you said. It says to monitor it, because its a possibility, not a definate response.

Answer

These are considered to hare a MAJOR interaction (source: drugs.com):

omeprazole ↔ citalopram
Applies to: omeprazole, citalopram
ADJUST DOSE: Coadministration with CYP450 2C19 inhibitors may increase the plasma concentrations of citalopram, which is partially metabolized by the isoenzyme. In 12 healthy subjects who had received citalopram 40 mg once a day for 21 days, administration of cimetidine 400 mg twice a day for 8 days increased the steady-state citalopram peak serum concentration (Cmax) and systemic exposure (AUC) by 39% and 43%, respectively. In addition to inhibiting CYP450 2C19, cimetidine is also an inhibitor of CYP450 2D6 and 3A4, both of which participates in the metabolism of citalopram. The extent to which sole inhibitors of CYP450 2C19 may inhibit citalopram metabolism is unknown. Clinically, high plasma levels of citalopram may increase the risk of QT interval prolongation and torsade de pointes arrhythmia.

Expand...

In a randomized, double-blind, crossover, escalating multiple-dose study consisting of 119 healthy subjects, the maximum mean increase in corrected QT interval from placebo was 8.5 msec for citalopram 20 mg and 18.5 msec for citalopram 60 mg. Based on the established exposure-response relationship, prolongation of the corrected QT interval was estimated to be 12.6 ms for citalopram 40 mg. Cases of QT interval prolongation and torsade de pointes have been reported during postmarketing use. In general, the risk of ventricular arrhythmia in association with QT prolongation is largely unpredictable, but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia).

MANAGEMENT: Given the risk of dose-dependent QT prolongation, citalopram dosage should not exceed 20 mg/day when prescribed in combination with CYP450 2C19 inhibitors such as cimetidine, esomeprazole, etravirine, felbamate, fluconazole, lansoprazole, letrozole, modafinil, omeprazole, oxcarbazepine, ticlopidine, and voriconazole. Alternatives should be considered when possible, and hypokalemia or hypomagnesemia should be corrected prior to initiation of citalopram treatment and periodically monitored. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, palpitations, irregular heartbeat, shortness of breath, or syncope.

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This combination is VERY BAD FOR YOUR HEART.

RonMan

Votes: +1

Answer

Omeprazole affects the pH of the digestive system which can affect the absorption of other medications. I don't believe in this case it is enough to be concerned, but a pharmacist can tell you if the citalopram dosage should be adjusted to take into consideration the omeprazole effect.

Answer

I agree, that would be a pretty serious interaction, and should be there. I've never heard that either. I'll check around and see if I can find anything.

Answer

ive never heard that an have occasionally taken the two together an bern ok, if it was an issue an interaction came up id of thought

Hi all, Citalopram & Omeprazole question?

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