In the past I have taken both brand name and generic Wellbutrin XL and noticed a significant difference. I've tried to switch from brand name to generic twice in the last couple of years, and both times came to the realization that the generic Wellbutrin/ Bupropion XL is nothing like brand name. But recently my insurance co-pay has gone from $50 to $150, and I'm wondering if anyone has found a generic Wellbutrin XL that feels equivalent to the brand name. Any opinions on what the best generic is?
Hi, Effect! The FDA dictates that the quality and quantity of active drug must be precisely identical to the brand name. The problem arises in the *fillers* that used to formulate the tablet/capsules and those include aspartame, saccharin, lecithin, methylcellulose, sorbitan, and various dyes, colorings, and flavorings.
Since there are over a dozen manufacturers of generic bupropion you may find that what works for one person may not work for you. Find one that you tolerate well and request that your pharmacist stock that particular product for you. He can also check manufacturer's products for one that has the same formulation as GlaxoSmithKline's.
Good luck and best wishes, WCV
Hi Effect. I have taken brand name wellbutrin and generic bupropion through the years.I have taken SR and XL versions of both as well. I had many more side effects with the XL version of both the generic and brand. But the SR version of bupropion seemed to me to be comparable to the brand name one. A few years ago I took Wellbutrin and also Bupropion. The different pharmaceutical companies who produced them made a difference as well. After much time and trying many different generic forms, I found one that worked the best for me, and most like the brand name. It is made by a company called Mylan pharmaceuticals, and it is Bupropion SR 150 mgs, to be taken once or twice a day, depending on the dose your doctor thinks is a better fit for you.
I had some very adverse side effects on the ones made by Sandoz pharmaceuticals and Par pharmaceuticals, Globe pharmaceuticals, and Activis pharmaceuticals. I had everything from stomach cramps, to headaches and weight gain, and increased appetite on the other generics. Hope this helps.
Hi Effect - there are huge differences in the generics for Wellbutrin. I've been taking this med since 1993 and was on the Glaxo brand for many years and then tried several time release versions of XL. None of them worked for me. Now, I'm taking the Sandoz generic 75mg. (3 times per day). I highly recommend Sandoz, and they also make the time release versions as well. Also, other reviewers have said that Sandoz is just as good as the brand. If you order this generic from your insurance company's mail order pharmacy - your co-pay should be the same as for all generics. Good luck - this is a very common problem for those who have tried cheap versions of Bupropion and who are still seeking an effective replacement for the brand.
I have tried the Sandoz manufacture brand and its awful. The first night I had ringing in the ears and dry mouth. I also started off with a shocking pain in my knee. I cut it in half and was having these phantom itches on my back and then hair loss. Im trying to find a pharmacy that carries the Mylan brand. I also started getting huge pimples.. Now my immune system is being compromised with sore throats and cold sores.
CIPLA has been the best for me, but we switched insurance companies and I can't use Target or CVS which dispenses this brand. So I am on the hunt for another good generic. Activis is a fail, I can tell a huge difference, it is inferior.
I’ve also had many problems. Finding the one that works best, has been a royal pain!
I recently had a coupon for the Brand name WellbutrinXL 300, that would make the cost $5 or less! I thought, YES! If this generic is working, the brand should work even better, right? Not so much! Well, between my insurance & this coupon, it was FREE for 3 months. The coupon exp 12/31/17 & now I have to go back to the generic. I should also add, my 3 months on the brand were NOT what I’d hoped. My depression dipped, my nerves were fried, I was isolating & most days I couldn’t even stand myself. I Remember thinking “my body is trying to adjust to the brand name.”
Now I’m making the switch back to my trusty generic & I feel like I have the flu! Headaches, body aches, nausea, severe stomach pains... My first thought was I have the flu. Then I realized I don’t have a fever. I started putting 2 & 2 together. I remember this feeling when I switched from the generic to the brand... YUCK!
To answer your question...
I found the best generic “FOR ME” is a round, coated tablet with the imprint “A 102” I have gotten friendly with my pharmacist, due to the issues I’ve had over the years, she knows “A102” is the only one I can take. She works hard to make sure I’m taken care of. She tells me there are several different generics on hand in the pharmacy. They typically grab the 1st bottle on the shelf & fill the script.
Find a pharmacist you feel comfortable talking to & explain what’s going on. My reactions to another generic was SEVERE! It’s OVAL & it is NOT coated. I don’t recall the imprint.
I became severely depressed, almost immediately & extremely suicidal in less than a week. This has happened 3 different times, over many years, before I figured it out. There is definitely a difference when it come to generics! This generic A102 is amazing! Idk what I’ll do, if there comes a day & I’m unable to get my hands on it.
Best of luck to you. I hope this is helpful.
I have been taking the generic form of Wellbutrin XL for many years now, only because my insurance won't pay for the brand name and, at $1000 a month, I can't afford it. If I could I would pay to have that instead of any generic medication, in a heartbeat! The generic Bupropion XL 300mg pills I take are small and round and made by Par Pharmaceuticals. My pharmacy started getting the drug, that I've taken for years, from a different manufacturer (Cipla USA Inc.) without notifying me. I only noticed because these new pills were oblong and larger. I did not think anything of the switch because I have always been told that the generic is the same as the name brand, just cheaper.
I took one of the pills from the new manufacturer and within hours I started experiencing extreme anxiety, rapid heartbeat, muscle cramps, elevated blood pressure, headache, shivering, "brain zaps"! It was a horrible experience, and I truly did feel like I was going crazy! I am so digusted with us not being able to have access to the medications we need that I even started a change.org petition to urge the FDA to actually do their job. Anyone interested in signing can look it up. I shared more of my story and others experiences about this issue on there.
The FDA "regulates" by mandating that generic forms of prescription medication contain the same active ingredient as the brand name, but allows the generic product to have as much as 20% less of the active pharmaceutical ingredient. Also the agency allows the generic version to use different inactive ingredients, including binders to hold the pill together and time release agents to disperse it. I feel like a lot of the issue is the dispersing agent because some generics actually feel like they "dump" the drug into my system all at once, or a lot of it anyway.
I've started Wellbutrin xl 150 mgs for 3 weeks and increased to 300 mgs after then. All together I'm already in week 4 and I see no difference. Nothing! It's like I'm taking a sugar pill! I buy my prescriptions at Costco and the generic they use is made by Par Pharma. Do you think the lack of effect could be because of the generic?Any experience with that one?
According to a knowledgeable professional who has worked in mental health for probably 20 years, PAR genetic brand is best because it is closest to the exact formulation of the brand name wellbutrin.
I just started taken bupropion for the first time ever, and am on the generic from BluePoint Labs. Anyone have experience with them? I'm feeling nothing, barely any side effects (just a little in the stomach once in a while and tight jaw sometimes) and no effect on my depression, unfortunately. Do you think it's worth it to try other generics? I could use the couple for Wellbutrin, but when that runs out then I have to go back to generics so there's no point really.
I believe that Mylan Pharmaceuticals Inc.. makes a good generic. However, many chain pharmacies are switching to other generics because the contracts are cheaper.
Just thought I should add my experience here! One random generic gave me a slight allergic reaction. That's when I stopped taking it and researched different generics. People said good things about Mylan and Sandoz. So I tried both!
My prescription is 100 SR (once a day for me). With the Mylan, I almost felt no effect. No good stuff and no bad stuff. Pretty underwhelming. With Sandoz, my depression is very noticeably lifted! It can feel like a miracle sometimes. I'm still around 6 weeks in. I recently started to get anxiety from the Sandoz, so I switched to Mylan for a few days to let my brain chill out. I'm back on Sandoz now and am feeling great so far!
I'm thinking of trying out different generics to see which one works best for me. If I could avoid the occasional anxiety, that would be ideal. I'm thinking of trying Watson next.
For anyone that feels like giving up after one bad experience with a generic: keep trying! It was a bit discouraging for me at first but I found something that almost completely silences the horrible bully in my brain. It gives color and energy to my life. Don't give up - the right med (or combination of meds) is out there for you!
I started taking Bupropion XL 150mg 24hr about 3 months ago and have gotten a different generic manufacturer from my pharmacy each month. First Actavis, then Lupin and now PAR. Actavis seemed to work best for me, but it also may have been that I felt the most effect from it because I was starting from 0. Lupin felt like I was back at 0 and PAR seems a bit better, but not much.
I called my pharmacy today to see which manufacturer they have available so I could do some research before refilling. Turns out they have two completely different manufacturers available now - IMPAX and Accord - neither of which I’m able to find much on in the way of reviews. Does anyone have experience with either of these? TIA.
I've only tried generic. I was started on
150mg mfg by Lupin and had to drop it because of excessive hair loss after 3 months. This is the only medicine that has helped me, so I tried 75mg mfg by Heritage, in hopes that the lower dose would stop or slow down the hair loss. Symptom never subsided so I came off bupropion all together. I'm desperately seeking a way to get around the hair loss so I can go back on the meds. Wondering if brand name would still give me the same symptom.
Good Luck on your search to find the best generic that works for you. Been there, done that. Unfortunately, all Pharmaceuticals want a piece of the "anti-depressive" market as a revenue stream. This explains why so many bupropion generics are available, and the list continues to grow at a rapid pace. With that said, it'll be difficult to find the one true generic that provides equivalent effectiveness (to each individual or particularly you) as the brand name. The cost of brand name continues to increase. There is no known generic considered to be as universally effective. Local pharmacies choice of generics is driven by the bottom line. Therefore, they do not stock generics based on a scientific measurement of effectiveness, but the least expensive. Most Pharmacies here issue Anchen Par brand generic as it known to be among the least expensive on the market (and as far as I'm concerned, and as others on this blog has pointed out, ineffectual).
I too searched for the most suitable antidepressant. Mylan, Lupin, Watson, jubilant, etc. cannot be found here. I've been taking Actavis generic on a consistent for some time now. However, I have to special request it. It's ok. However, I don't know if it continues to benefit me or if I'm just living a better life; thinking better thoughts; caring less of what people think of me (a trigger), managing seemingly negative situations, and appreciating my self-worth.
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