In the past I have taken both brand name and generic Wellbutrin XL and noticed a significant difference. I've tried to switch from brand name to generic twice in the last couple of years, and both times came to the realization that the generic Wellbutrin/ Bupropion XL is nothing like brand name. But recently my insurance co-pay has gone from $50 to $150, and I'm wondering if anyone has found a generic Wellbutrin XL that feels equivalent to the brand name. Any opinions on what the best generic is?
What is the best generic Wellbutrin?
Question posted by Effect on 11 Feb 2016
Last updated on 26 January 2022 by TBISurvivor
At my last fill, the pharmacy switched to generic bupropion XL 150mg, produced by Slate Run. I started having random crying spells, sometimes for very little reason. When I pick up my next refill tomorrow it'll be from Cipra, because I don't have any problem with theirs. I had never known that genetics could be so different!
I’ve been on generic 300mg XL for a year and had Cipla - it worked great! My last Rx refill was from Slate Run pharma and for the last 3 weeks it’s felt like before I was ever on it. My pharmacy just gave me a 30 day supply of Activis and will try that as they haven’t stocked Cipla in awhile. They also had Lupin and Par in stock…the pharmacist said he’s gotten most complaints from Par. Fingers crossed this works!
ACTAVIS Brand is the first generic
brand I started on. It has always worked for me. One time I was changed to a different generic manufacturer, and after 2-3 weeks, I wasn't feeling right?? But didn't know why?? A little over a month later, it dawned me??? The different brand of my bupropion!!! After I had it changed back to the ACTAVIS Brand, I've not had any problems. Now I won't even try another manufacturer for fear it wont work!
I was taking Wellbutrin SR and insurance switched me to Bupropion XL SR. Now I am currently taking Bupropion XL by Lupin, which I have never heard of. I just switched from Walgreens to Smart Scripts, and I think that the XL/SR combo works much better for me. I am taking the 300mg dose.
I cannot definitively say which generic is "best" as it seems to be very specific to each person's brain chemistry. However, this is my experience: I was on TWI Bupropion XL 150 for a little over a year, and had no complaints. My depression was mild-moderate before medication, and seemed about 80% in remission while on meds. I just changed insurance providers, and now have been put on the Par bupropion XL. 3 days after switching, I started experiencing severe anxiety including cyclical anxiety attacks that happened routinely at the same time each day. I also began having intrusive thoughts and suicidal ideation. Once I realized the problems were happening on a set schedule daily, I immediately started tapering off the med. Sure enough, the anxiety attacks stopped.
As of today, I now no longer take Bupropion (switched to Sertraline), but only realized in hindsight that the only change to my routine that could have caused this was the switch in generics. I believe it was something about the time release of the Par tablets that was spiking my anxiety so badly. I'm still dealing with residual issues even after I tapered off, so I will be paying MUCH closer attention to generic manufacturers for all of my medications moving forward.
The generic PAR brand works, period. The PAR brand generic is the only brand that I've found that works even remotely close to brand Wellbutrin. I TOTALLY and completely understand this nightmare because I've been thru it myself. After switching from brand Wellbutrin to generic due to cost, I tried probably 4 other generics that didn't work... and for months I got those head zings and whooshes and all the other really awful mental stuff that occurs when one drug that works is leaving your system and being replaced with one that DOESN'T work. When I found the PAR brand, I knew within a week that I was in the right place. Everyone is different, but I've heard from more than a few people that PAR brand solved their issues. Ask your Dr to write your script for SPECIFICALLY the PAR brand and see if it works for you too. I know how hard it is to search and search for something that WORKS when you are actively depressed...
it just seems too hard and overwhelming sometimes. PLEASE, trust me on this one and try it immediately if the other generics aren't working for you, and good luck... this mess won't last forever, just try to bite the bullet and keep trying. You're worth the effort and it just may work for you too. Gentle hugs !!
I have also had great success with the Activas manufacturer. But it is currently out of stock nationwide with no dates of availability. I have tried three other generic manufacturers and they all make my symptoms worse. It's like taking nothing whatsoever. The name brand Wellbutrin is astronomically expensive. But here is what I have found: If one has private insurance (not medicare or medicaid) the manufacturer offers coupons than reduce the copayment to only $5. I used this coupon for the first time last month. Both my pharmacist and myself were surprised but it absolutely worked. Your physician must write Dispense as written on the Rx for the name brand. The drug company picks up the reminder of the coat after your private insurance pays.
I have experienced a terrible problem between two manufacturers of the generic 300 mg XL. One manufacturer (Actavis), I tolerate well and do absolutely perfect on. The other one that I have tried (Accord), makes me sick as a dog. I have stomach pains, diarrhea, dizziness, heart racing, and headache. My pharmacy was ordering the manufacturer that I tolerate for me but now that version is no longer in stock anywhere and on backorder. I tried switching to the other manufacturer again (just to see if it really did make me that sick) and now 3 days in and I am sick as a dog. After some research, this seems to be a very common problem with generic versions of Wellbutrin. I really think the FDA needs to get involved again. I made a report (doubtful it will do any good).
I have a call into my doctor to see if he can put me on the name brand or take me off the XL and see if that helps. But I absolutely can NOT tolerate the 300 ml buproprian manufactured by Accord. Waiting to hear back from my doctor and what he will suggest.
Please know that none of you are alone in your struggles with generic brands of bupropion.
I have taken Mylan SR for years. When they took it off market I managed to get a few 100 and have tried to taper off the drug. This is been a terrible battle. Not from depression but the side effects of withdrawal,nausea, weakness, syncope - 3 trips to ER, they can't do anything. I have tried the Wellbutrin brand by GSK and found it's like not taking the drug at all, same withdrawal symtoms, also tried two other generics. Now I am switching to Mylan 75 mg which they still make but is currently back ordered. I am going to keep trying to get off of this medication because of all the difficulty with brands and how different they are. It breaks my heart to read how we are all struggling with this medication. I'm going to try Neurofeedback next. Has anyone gotten off the medication? How long did withdrawal last?
Generics are nothing like the name brand Wellbutrin and can put you over the edge. Par Pharm is the worst. sugar pill plus later wanting to end your life. Does nothing good. Its very concussing to believe Dr. FDA when the say the generic for is safe and the same as the name brand. Not true and I don't know how they get away with this betrayal. Name brand is amazing for depression and chronic fatigue buy caution it can cause anxiety.
Has anyone had experience with Alembic pharmaceuticals bupropion 100 mg. It seems stronger or different then Apotex?
I have been taking BuPROpion for several years now. I found that the SANDOZ works the best
for me. My regular pharmacy tried to give a different brand a couple of times. They either did
not work or messed me up. I took them back and requested SANDOZ.
Recently I requested a refill and was told they could no longer get the SANDOZ brand. I ask
them what brand they could provide. I looked them up and saw they were not going to work
for me. They said they had a contract with their supplier and there was nothing they could
I started to have an anxiety attack concerned I would not be able to get SANDOZ anymore.
I have a couple of weeks worth so had some time to look around. I went to 6 different
pharmacies and found 2 that had some in stock. Two that said they could not order it.
and 2 that said they could order it. So I picked the one that was closest to my home and
they ordered it and had it in 3 days. They had to xfer my prescription from my regular
What a pain. If SANDOZ ever stops making BuPROpion I am in deep trouble.
Does anyone know of other brands that are as good as SANDOZ and still made?
I know that SANDOZ does not work for everyone but seems to be highly regarded
by the people that have responded to this question.
Thanks to all that have responded to this question. It has been very helpfull.
I cannot take most generic brands of Wellbutrin. They dont work for me at all! The only generic I can take is the Par Pharmaceutical brand which is the same in size and appearance of the Wellbutrin XL brand name medication. The newly approved Lupin brand looks the same so will try that since Par is increasingly more difficult to obtain.
Just be sure the manufacturer is routinely inspected by the FDA. I wouldn't trust drugs from any manufacturing site in India regardless if FDA inspects them. I worked in the pharmaceutical testing industry.
With the loss of the Mylan generic, Anyone try the Par Pharmaceuticals generic Bupropion XL? Par was apparently one of the only other generic manufacturers to actually demonstrate bioequivalence with the name brand Wellbutrin XL.
I've been on 150 mg tablets of Bupropion XL, first one, then two after a week. So far no major ill effects from this, and it does seem to be helping. Time will tell. My doc also recently filled a prescription for 300 mg tablets from the same manufacturer, so we'll see how that goes.
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