... I am on 60 mg of Cymbalta, have been for years and I do believe it helps my depression more than using Wellbutrin alone. I have noticed a very strange reaction if I miss a dose of Cymbalta and would love to know if anyone else has experienced this. When I miss a dose of Cymbalta I have the absolutely most technicolor wild-ass dreams I can imagine. They are the kind of dreams that are near impossible to wake yourself out of, because they seem so very real. I have even experienced this if I take a morning nap and have not taken the Cymbalta. All I can surmise is that the Cymbalta really acts on my brain chemicals in a strong manner. These dreams are never pleasant and they stand out in my mind for days. I don't want to sound like a whiner or a weirdo, but I would really like to know if anyone has had the same experience. I have always tended toward strange dreams (night terrors as a child) so maybe this is a normal variant for me. But sure would love to hear from someone who has the same experiences. Thanks so much!
Anyone have strange dreams when they miss a dose of Cymbalta?
Question posted by LeighBa on 1 April 2016
Last updated on 1 November 2022
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18 Answers
I am the opposite. I have the most crazy dreams if I take it to close to bed time. I can’t even function the next day.
I had the crazy dreams as a side effect from Cymbalta also and I took it at noon time. There are many others experiencing this in the Cymbalta support group I’m in.
Some very sensitive people might begin to feel early discontinuation symptoms within just hours after missing even one dose. The trick is to somehow try to make sure you don't miss that dose. Nearly everybody has a phone... set yourself an alarm.
If you miss a dose take that dose as soon as possible as long as 8 hours pass before your next dose is due.
I have nightmares when I miss a dose. They’re bad. I talk and scream while asleep. Sometimes I even move my legs and arms and have hurt a loved one… and I can’t wake myself. I have had sleep disturbances all of my life. I was a sleepwalker as a child. On occasion I still sleep walk. But the nightmares are awful. I try to never miss a dose just to avoid the dreams.
I missed one dose last night and just woke up from a sever night terror that I couldn’t get out of. I’m on 30mg 1xdaily and I missed last nights dose (honestly I was just lazy and fell asleep). That mistake started an all night nightmare that I couldn’t wake up from!! I will never miss a dose again. This is the 2nd time this has happened and it’s the same feeling after. Groggy, aloof, and night terrors that I can’t shake off. I truly love taking this medication, it has helped tremendously. But holy shit don’t miss a dose or you’ll be unlocking true fear in your dreams.
I'm 64 years old and have been on 60mg of Cymbalta since 2013 for depression and chronic back pain. For the last year it seems as if the Cymbalta is not helping my chronic back pain nor my depression, plus the sweating which never used to bother me has become intense and I'm always tired and want to sleep, plus I just feel crappy all of the time and in a bad mood.
After researching Cymbalta, listening to what other people who are on it and have been on it, I decided to start wiening myself off of it starting January 1, 2022. I also have migraines. The last 2 days I have been in bed with a migraine, which I believe is due to wiening myself off of Cymbalta, and I completely forgot to take my Cymbalta for the last 2 days due to sleeping trying to sleep off this migraine..
I have had the most vivid, weird, strange dreams unlike any I have ever had in my life. These dreams are so intense I can barely wake myself and these dreams details stay with me.
I've always dreamed all my life, but never anything as weird and vivid as these and most of my dreams I would forget. Not these. I am convinced missing 2 doses of Cymbalta is the reason for these very strange and vivid dreams that stay with me.
I am so glad I am getting myself off of Cymbalta. Whatever is in this "drug" should have NEVER been allowed by the FDA to be produced and approved for anyone or anything.
{23 yr female} I had a really messed up dream last night. So vivid and disgusting and dark I’ve been thinking of it all day. So while discussing this horrid dream with my boyfriend I thought about the fact that I’m almost a month in on my duloxetine. I missed my dose last night (I work 6am-2pm so I’m up at 3am to be at work on time. Didn’t think of taking it when I got home to sleep.) I went online to find answers cause a lot of meds cause dream disruption. So finding this really helped answer my question of why I had such a god awful dream. I’m telling you it was laced with such despair and gore that I woke up questioning myself and my reality. (Had only been asleep 2 hours) I’m glad I’m not alone in this.
For reference I am (21) and take (60mg) I googled this because I woke up after a night a strange dreams and was really relieved to see I wasn’t the only one. I’ve always had very Vivid dreams that would occur every night even as a child. But recently I noticed If I miss my daily dose of cymbalta I have disturbing dreams. I wouldn’t describe them as scary or night terrors but rather a very cinematic stretch of dreams that are very very real and disturbing. And I wake up confused and disgusted that my brain would even think of such things. I’m glad I’m not alone
I can't believe I found this.
I woke from said dreams and thought i'd Google it.
I never had night terrors as a child, but these surreal dreams are the EXACT re-occurring dreams from when I was a child.
It's unreal how our brains can hold something sub-conciously like this for 20+ years. Then me running out of the meds over the weekend brings it all back.
To think I only take them as a muscle relaxant. Mmm
I am on 60mg, and I was just searching for this and found this thread. I've had the same exact experience. Terrible nightmares after missing just one dose, extremely vivid and specific, and after I woke when I fell back asleep I went right back into the same one. I woke up screaming after one in which I heard what I thought was a very very real crashing sound in the room, but it was all in my head. Definitely am not going to miss a dose again.
Oh my gosh, I queried this question and found your comment. I have had the exact issue for years. MISSING a dose consistently causes all-night, vivid, crazy dreaming. I missed renewing duloxetine in time, and after two missed doses am just getting over an exhausting night of epic dreams that endured for hours with the same theme of never-ending trials and trying to escape.
Without fail, missing one dose (120 mg. per day) induces this. Years ago Celexa caused this during dose build-up and for months afterward, but I have never experienced a dream effect as dependably as missing this dose. I also, am taking buproprionXL (300 mg. daily) with the duloxetine generic.
Yes, missing a dose brought on such horrific nightmares. Not the typical slasher nightmares however. It’s deepest fears in your brain exposed in a dreamscape form. When awoken I would fall back to sleep to enter where I left within the dream. I would wake to get up and feel I didn’t sleep at all and have the emotional feelings of what those dreams where. I had my cymbalta increased from 60 to 120 recently, which doubled the effect.
I'm hoping your situation has improved. I'm been on Cymbalta for about 2 months now. Moved up to 60mg and backed down to 45 to try to eliminate some of the insomnia. I skipped my dosage over the weekend and had the horrible, vivid nightmares you described over the weekend and woke up in a sweat. Did you get these nightmares any time you skipped?
This is a common, and one of many possible, symptoms of discontinuation syndrome which can begin as early as several hours of a missed dose.
Make a point of not forgetting or missing doses and have your prescription refilled before you run out. Setting an alarm on your watch or cellphone is a good way to remember.
Yes. I accidentally ran out and so today was my third missed dose. I just took a nap because super tired. Crazy dreams and I couldn't wake up even though I felt in a fog and strange things happening. Awake now but head is in the same kind of fog. Don't like this feeling at all.
Yes this happens to me every time and I’m only on 30mg. Weirdest dreams ever! Also, the level of fatigue I feel when I miss a dose is very intense. It’s a fatigue I can’t brush off. I literally have to nap and then I get very weird vivid dreams.
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cymbalta, wellbutrin, depression, reaction
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