Can you take Wellbutrin XL and Cymbalta together?

Interactions between your drugs
Major
buPROPion DULoxetine
Applies to: Wellbutrin XL (bupropion), Cymbalta (duloxetine)

Talk to your doctor before using buPROPion together with DULoxetine. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. In addition, buPROPion can increase the blood levels of DULoxetine, which may increase other side effects. You may be more likely to experience seizures with these medications if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should avoid or limit the use of alcohol during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Source: https://www.drugs.com/interactions-check.php?drug_list=440-2469,949-2273

I don’t think you should take them together unless you talk to your doctor. When I was diagnosed with anxiety, I started out with a low-dose of Cymbalta along with Ativan (lorazepam is the generic). As I got accustomed to a higher dose of Cymbalta, I was taking less and less of Lorazepam until I didn’t need it anymore. The Cymbalta took full effect after about 2-3 months. That was almost two years ago. So glad I had Lorazepam along with Cymbalta the first few months. Maybe ask your doctor about this combo. I’m as happy as a lark! Good luck.