My doctor started me on Viibryd about a month ago after I'd been on Lexapro for years and it had stopped working as well. I did the standard step-up dosage pattern with the starter pack... started at 10mg and was up to 40mg by the 3rd week. I should mention that I am anorexic and bulimic and my doctor is well aware of this, and when he told me about this new Viibryd medication I adamantly stated that I CANNOT be on anything that causes weight gain. (I also take 450mg of Wellbutrin XL and have been for several years now.) So he promised me that Viibryd doesn't cause weight gain and I agreed to start taking it. A couple of years ago, I lost a ton of weight (110 pounds) through diet and tons of exercise and managed to stay at about 100-105 pounds for a good 6 months, even AFTER I stopped exercising completely.
Well, suddenly I started gaining weight rapidly about a month ago, and so I freaked out and started going to the gym again and working out hardcore (which I know produces results because that's how I've lost weight and kept it off in the past) and immediately changed my eating habits. Yet I'm still steadily gaining weight at an alarming rate and the only explanation I have for it is that it's the Viibryd. I know it's not normal to exercise hardcore, eat healthy, and STILL gain weight. I now weigh 120 pounds and the number has just steadily climbed up since I started Viibryd. I don't understand this at all. I weigh myself everyday and monitor every single thing I eat. I track my caloric intake religiously and I know exactly how many calories I've burned during my workouts, and nothing can account for this weight gain other than the medication. If anything, I should be LOSING weight since I just went from sitting on my butt all day to an hour of cardio a day, but this is not the case. In the 3 weeks since I started working out hardcore, I've gained 5 pounds (no, it's not from fat converting to muscle). I think Viibryd needs to be tested more and an updated report of side effects needs to be published. No amount of depression in the world is worse than weight gain for me, so it's ironic that an anti-depressant is causing me to want to kill myself due to a side effect that seems to be a lot more common than the pharmaceutical companies would have you believe. I'm going to stop taking the Viibryd as of today and I don't care what my doctor has to say. I'm hoping I'll be able to take off the 10 pounds I've gained in the month since I started Viibryd once I stop taking it. I'll make sure to post an update to this thread once I've tapered myself off to let everyone know if anything changes. I'm just really upset because I was led to believe this medication wouldn't cause any weight issues. I've also had an increased craving for sweets, but I haven't given in to it because I know what sweets do. I'm also incredibly bloated since starting the Viibryd. Has anyone else had similar experiences with weight gain and this medicine and past eating disorders?
Viibryd had no effect on body weight as measured by the mean change from baseline in the 8-week, placebo-controlled studies. The mean changes in weight were +0.16 kg in the Viibryd group and +0.18 kg in the placebo group. The proportions of patients with a weight gain ≥ 7% were 0.9% in the Viibryd group and 1.2% in the placebo group. The proportions of patients with a weight decrease ≥ 7% were 1.4% in the Viibryd group and 1.4% in the placebo group."
Please note that Viibryd contains a stronger norepinephrine reuptake inhibitor than Wellbutrin as well as an SSRI. Wellbutrin is a weak norepinephrine reuptake inhibitor. This additional 450 mg of an norepinephrine reuptake inhibitor may be causing an interaction.
Also, Wellbutrin has a strong indication for weight loss a dosages above 400 mg (19%). It would seem that adding Viibryd has negated the weight loss effects of that much Wellbutrin.
Please see your doctor and have him/her look at the details of the interactions of these two drugs. Normally Viibryd is not used at the same time as Wellbutrin. I was taken off Wellbutrin when I started Viibryd.
As always, your milage will vary.
3 May 2013
Hello daseniura, Thank you for your informative post. I would appreciate any follow up information you can bring to the group. Together with RonMan's research, I think we may actually be a bit ahead of the learning curve about the a certain % of individuals who are so effected by Viibryd. Best Regards, 4N Substances
3 Jul 2013
In May I was 105lbs when I started on Viibryd which was recommended by my PCP. With no changes in my eating habits, lifestyle, or medications now at the beginning of July I am at 141lbs. My weight has been steady for years and has not been an issue in the past.
After speaking with a Psychiatrist I'm currently weaning off Viibryd. They said they've had quite a few patients come in where the PCP has given them a sample pack and prescribed Viibryd. The pharmaceutical reps are showering Drs offices with starter packs and saying (as the "clinical study") Viibryd does not cause weight gain or have sexual side effects. Many of these patients also experienced unexplained weight gain.
I have experienced more energy and less anxiety while taking Viibryd. However, the side effects for me are horrendous. It's not worth becoming overweight and causing additional medical issues. I wish I could loose 35-some lbs as quickly as gained it.
30 Jul 2013
Normally not recommended to prescribe Wellbutrin to anyone suffering from from Anorexia/Bulemia, especially not in such a high dosage! With 450 mg being the maximum recommended dosage daily, in order to avoid the risk of seizure. This risk is greatly increased when patient is anorexic and/or bulemic. You may want to search Wellbutrin in this site and review the Major Drug Interactions section, for further info.
25 Oct 2013
I had the uncontrollable weight gain as well. I've never had problems with my weight all my life. It's always been consistent - I never like sweets, EVER! but since taking Viibryd, I had this uncontrollable urge and cravings to eat sweets lots of it too. Within 7 months of taking this medication, I have gained 20 lbs despite the excessive training and amount of time spent at the gym (being a bikini competitor). I ended up dropping out of the contest because of the weight gain. No matter how hard I worked out, the scale wouldn't budge. I decided to taper off (under doctor's supervision) Viibryd due to other side effects I was having. Today is my last dose and then I'm done. What's strange is that after I came off from 40 mg to 20 mg, I've noticed the decrease appetite right awa, craving for sweets had also diminished and that's when I realized that the correlation between my weight gain and viibryd. I'm staying away from this drug!
9 Nov 2013
I am really pleased to find this thread, and I hope to see more such threads on the internet spreading awareness of this under reported side effect.
I too have gained rapid weight on viibryd. Approx 20kgs. I weighed about 57 kgs before starting viibryd in August 2012 and now a little over one year later I weigh 73 kgs. I gained the weight within the first 4- 5 months. Very upsetting. I am 29 years old and all my life I have weighed under 60kgs, even when I have been eating loads and not exercising the max my weight ever went to (before viibryd) was about 60kgs.
I refused to believe it was the medication because the official research clearly states that it is not a common side effect, but it just can't be a coincidence that I was practicing the same eating habits and then suddenly gained weight AFTER starting this medication.
Much love to all.
9 Nov 2013
Thank you all! I have finally figured out the cause of my amazing weight gain!!! As is the case with many other people who have tried Viibryd, I experienced a severe rapid weight gain (more than 70 lbs in just a few months) but because I was told that Viibryd is "weight-neutral", I blamed that gain on the many other factors in my life which could have caused it which include a tendency to be lazy and overeat, love of ice cream and other sweets, binge/nighttime eater, and just the quality I possess of being a "bigger guy." I finally realize that there is a problem with Viibryd. Never was it even questioned that the Viibryd was the cause just because we all (me, my psych, and my therapist) understood that Viibryd did not cause weight gain.But my experience is so similar to the other responses that it cannot be a coincidence.
9 Nov 2013
Yes, I think you will see on here and other sites where people talk about their experience with Viibryd that weight gain and rapid weight gain is a side effect. Why it keeps being reported by the company as not causing weight gain is beyond me. I think it's only to get more people to try it. My psychiatrist told me it could cause weight gain but I was not expecting to gain 25 lbs in two months! I've been off Viibryd for almost a year now and have finally gotten back to my weight before I started Viibryd. Good luck!
4 Feb 2014
I started on Viibryd 4 months ago. I have gained 30 lbs. I have been trying to figure out why. I feel like a swelled up balloon. I have never gained weight like this before in my life. And it just dawned on me yesterday that the thing that had changed was viibryd. I too had been told that viibryd couldn't be the cause. But the facts are what they are. I am weaning off this stuff ASAP. I willing take my chances with depression. But I don't want to depressed and overweight. Thank all for speaking up here!!
6 Jun 2014
I have also read the full prescribing information that states that Viibryd does not cause weight gain. But I am here to tell people otherwise. I have gained weight rapidly with Viibryd just as it seems others have on this site. It's really quite distressing. Weight gain can cause just as much depression as any other issue. It really should have been addressed in the initial chemical make up of this drug. Very disappointing.
11 Jun 2014
Yes. I am 23. I'm 5'5". My normal weight had always been 120-123. once i got on Viibryd in less than a few months i was 145. and my eating habits had not changed. if anything, I was healthier i was working out more. I am working on getting off it but the withdrawal symptoms are horrible as well. so i'm going to speak to my doctor that and tell her that i can't continue on this drug any longer. because no matter what i do the weight just doesn't come off.
6 Jul 2014
I don't care what any pharmaceutical company, doctor or psychiatrist says. I have kept a detailed food diary for several months and was losing a pound a month on 1400 calories per day cycling 55 mins 5 days per week going an average 7 - 8 miles per hour. I am 5 '1" tall and WAS 130 lbs and steadily LOSING weight. After starting vibriiyd, after only 3 weeks, with NO changes, I went up to 142 lbs and from size 4 to size 10.
26 Jul 2014
Yes! I have gained over 20 pounds over the last year that I have been taking 20 mg of ViiBryd. I can relate to all of you that I thought it was other things going on my life. My doctor put me on ViiBryd because it is one of few that does not have sexual side effects. I find that I am particularly drawn to sweets but that just might be my personality.
12 Sep 2014
I am so thankful to find this site and all these responses about weight gain. I was told there would be no problem with weight gain, and like most of you, I have found myself getting fat as a pig... for no good reason; although I too have craved sweets (which is new too me..but I have fought those urges) nonetheless, in a period of about 6 to 7 weeks, I can barely fit into anything without feeling strangled by it & I am so bloated I feel like people will be asking me when i'm due, any minute now. I was fine, actually marvellous at the 10 dose, at 20 I just felt bloated, at 30 I REALIZED this was real weight gain and at 40 I was desperate. After reading all these responses I am convinced it must be the Viibryd. My shrink (the prescriber..he costs a fortune and is totally out of pocket) has cut me back to 20; but I think I need to go back down to 10. I know I shouldn't cut back on my own, but even a phone call to him costs almost $100.
If i wait for my next appointment I think my 35lb will have turned to 50lb. I haven't had eating disorders in the past, so my heart goes out to you. I am certainly worried and perplexed. I am on this medication because my entire family died one by one of cancers, all of them within a three year period... by year 4; I just lost mind. Major depressive order they are calling it, it should be temporary, but I just couldn't even think anymore, let alone do anything that included getting out of bed. It's a dilemma for me, i'm up and active and can think again, but it's only been 7 weeks... I'm not sure I have the right mind set. How sad to have to choose between the ability and frame of mind to get back to activity, but be too embarassed and tired from the weight gain to actually follow through. Or look good... laying in bed depressed, lost and lonely!
5 Apr 2015
I've only been on Viibryd 2 weeks and have gained over 20 lbs. My skin feels so tight and my head is always hurting. I'm stopping this stuff when I see my PCP again. Too much weight gain and discomfort only serves to aggrivate my depression especially when I'm just on the start up pack.
Subscribe to receive email notifications whenever new articles are published.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated Jan 9th, 2019), Cerner Multum™ (updated Jan 14th, 2019), Wolters Kluwer™ (updated Jan 7th, 2019) and others. To view content sources and attributions, please refer to our editorial policy.