I was on Serzone for years until they quit making it. My doctor put me on Cymbalta and I absolutely love how it made me feel. I started noticing that I was having muscle cramps a lot. Finally the cramps got to be so bad that I talked to my doctor about it. He changed my medication to Pristiq and I have been on it for 6 days now. I noticed a decrease in the muscle cramps for a few days, but yesterday and last night were one of the worse days ever. Does anyone else suffer muscle cramps from either of these medications? I am at wits end. I have cramps in places I didn't even know I had muscles. So so painful.