Half-Life: The terminal half-life reported for Methotrexate is approximately three to ten hours for patients receiving treatment for psoriasis, or rheumatoid arthritis or low dose antineoplastic therapy (less than 30 mg/m2). For patients receiving high doses of Methotrexate, the terminal half-life is eight to 15 hours.
It takes 5.5 x elimination half life for a medicine to be cleared from your system... so methotrexate will be out of your system in 82.5 hours (5.5 x 15 hours - using maximum half life), so you should be able to drink alcohol after that.
Everyone is different, but I stopped 3 weeks before my Halloween party, and was fine to drink. I had 4-5 drinks over the course of 5 hours. I had Nothing but a mild headache the next day. Before, I learned my lesson with drinking more than two drinks at a sporting event and I was so violently ill, vomiting, with the worst pain in my stomach, I never wanted to do that again. I'm currently on methotrexate and only stopped it for the Halloween party last year. It was a fun night. I do miss drinking, but I'm not tempting it again without taking a 3week break from the Metho. 3 weeks worked for me, it might be longer for others, I would definitely get off it for at least 3 or more weeks
- Methotrexate Information for Consumers
- Methotrexate Information for Healthcare Professionals (includes dosage details)
- Side Effects of Methotrexate (detailed)
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