Half-Life: The terminal half-life reported for Methotrexate is approximately three to ten hours for patients receiving treatment for psoriasis, or rheumatoid arthritis or low dose antineoplastic therapy (less than 30 mg/m2). For patients receiving high doses of Methotrexate, the terminal half-life is eight to 15 hours.
It takes 5.5 x elimination half life for a medicine to be cleared from your system... so methotrexate will be out of your system in 82.5 hours (5.5 x 15 hours - using maximum half life), so you should be able to drink alcohol after that.
- Methotrexate Information for Consumers
- Methotrexate Information for Healthcare Professionals (includes dosage details)
- Side Effects of Methotrexate (detailed)
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