I am using liquid IM 10mL Vial with preservatives and I store it in a dark, cool cabinet in between uses.
How long can a vial of Methotrexate with preservatives be used after seal is broken?
Question posted by JA MOM/lupie on 11 April 2012
Last updated on 12 April 2012 by Anonymous
Please let us know what form the Methotexate you are using is: intravenous, intramuscular, or subcutaneous (liquid, oil based, liquid). In a dark location at standard room temperature 66-74 degree F, even with a broken seal if it's a multi-dose vial the liquid should last in effectiveness for up to a year and the oil for up to two (though the FDA recommends discarding of any medication older than a year old). However, anything you are going to be injecting must also be considered for cross-contamination with airborne bacteria and illnesses. The liquid is most susceptible to contamination, the oil slightly less so. Because all forms are usually multi-dose vials when given for at home use (actually, at the Drs as well) even without the seal the pharma-demal (made up word) layer (the grey, black, green, or beige portion you insert the needle into to remove a quantity) will protect a conscientious individual from having to concern themselves with this possibility.
If you've located a single dose vial version (something I've never heard of), once it's exposed to the air the liquid should be used in no more than 2 weeks, and oil a month. Always check for cloudiness or particulate matter in liquid and oil based injectables before administration.
- Methotrexate uses and safety info
- Methotrexate information for Healthcare Professionals (includes dosage details)
- Side effects of Methotrexate (detailed)
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